scholarly journals The Dm-Myb Oncoprotein Contributes to Insulator Function and Stabilizes Repressive H3K27me3 PcG Domains

Cell Reports ◽  
2020 ◽  
Vol 30 (10) ◽  
pp. 3218-3228.e5
Author(s):  
Juan F. Santana ◽  
Mrutyunjaya Parida ◽  
Abby Long ◽  
Joshua Wankum ◽  
Anthony J. Lilienthal ◽  
...  
Keyword(s):  
Insulator Function

scholarly journals The zinc-finger protein CLAMP promotes gypsy chromatin insulator function in Drosophila

2019 ◽  
Vol 132 (5) ◽  
pp. jcs226092 ◽  
Author(s):  
Indira Bag ◽  
Ryan K. Dale ◽  
Cameron Palmer ◽  
Elissa P. Lei
Keyword(s):  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Chromatin Insulator ◽  
Finger Protein ◽  
Insulator Function

The many roles of the transcriptional regulator CTCF

2003 ◽  
Vol 81 (3) ◽  
pp. 161-167 ◽  
Author(s):  
Katherine L Dunn ◽  
James R Davie
Keyword(s):  
Transcriptional Repression ◽  
Genetic Information ◽  
Transcriptional Regulator ◽  
Nuclear Factor ◽  
Regulatory Regions ◽  
Insulator Function ◽  
Myc Gene ◽  
The Many ◽  
Insight Into

The nuclear factor CTCF was first identified as one of the factors binding to the regulatory regions of the c-myc gene. Further study of this protein revealed roles in transcriptional repression, insulator function, and imprinting genetic information. Recent studies have provided new insight into the mechanism through which this factor acts at various levels of gene regulation.Key words: CTCF, insulator, transcription.

scholarly journals Insulator function and topological domain border strength scale with architectural protein occupancy

2014 ◽  
Vol 15 (5) ◽  
pp. R82 ◽  
Author(s):  
Kevin Van Bortle ◽  
Michael H Nichols ◽  
Li Li ◽  
Chin-Tong Ong ◽  
Naomi Takenaka ◽  
...  
Keyword(s):  
Topological Domain ◽  
Insulator Function ◽  
Protein Occupancy ◽  
Architectural Protein

scholarly journals The RNA-binding protein Rumpelstiltskin antagonizes gypsy chromatin insulator function in a tissue-specific manner

2014 ◽  
Vol 127 (13) ◽  
pp. 2956-2966 ◽  
Author(s):  
M. R. King ◽  
L. H. Matzat ◽  
R. K. Dale ◽  
S. J. Lim ◽  
E. P. Lei
Keyword(s):  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Tissue Specific ◽  
Chromatin Insulator ◽  
Insulator Function ◽  
Specific Manner

scholarly journals Multiple Nucleosome Positioning Sites Regulate the CTCF-Mediated Insulator Function of the H19 Imprinting Control Region†

2002 ◽  
Vol 22 (10) ◽  
pp. 3339-3344 ◽  
Author(s):  
Meena Kanduri ◽  
Chandrasekhar Kanduri ◽  
Piero Mariano ◽  
Alexander A. Vostrov ◽  
Wolfgang Quitschke ◽  
...  
Keyword(s):  
Control Region ◽  
Insertional Mutagenesis ◽  
Site Occupancy ◽  
Nucleosome Positioning ◽  
Target Site ◽  
Chromatin Insulator ◽  
Insulator Function ◽  
Target Sites ◽  
Imprinting Control Region ◽  
Precise Distribution

ABSTRACT The 5′ region of the H19 gene harbors a methylation-sensitive chromatin insulator within an imprinting control region (ICR). Insertional mutagenesis in combination with episomal assays identified nucleosome positioning sequences (NPSs) that set the stage for the remarkably precise distribution of the four target sites for the chromatin insulator protein CTCF to nucleosome linker sequences in the H19 ICR. Changing positions of the NPSs resulted in loss of both CTCF target site occupancy and insulator function, suggesting that the NPSs optimize the fidelity of the insulator function. We propose that the NPSs ensure the fidelity of the repressed status of the maternal Igf2 allele during development by constitutively maintaining availability of the CTCF target sites.

scholarly journals Poly(ADP-ribosyl)ation Regulates Insulator Function and Intrachromosomal Interactions in Drosophila

Cell ◽  
2013 ◽  
Vol 155 (1) ◽  
pp. 148-159 ◽  
Author(s):  
Chin-Tong Ong ◽  
Kevin Van Bortle ◽  
Edward Ramos ◽  
Victor G. Corces
Keyword(s):  
Insulator Function

scholarly journals ISWI contributes to ArsI insulator function in development of the sea urchin

Development ◽  
2012 ◽  
Vol 139 (19) ◽  
pp. 3613-3622 ◽  
Author(s):  
M. Yajima ◽  
W. G. Fairbrother ◽  
G. M. Wessel
Keyword(s):  
Sea Urchin ◽  
Insulator Function
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