scholarly journals The RNA-binding protein Rumpelstiltskin antagonizes gypsy chromatin insulator function in a tissue-specific manner

2014 ◽  
Vol 127 (13) ◽  
pp. 2956-2966 ◽  
Author(s):  
M. R. King ◽  
L. H. Matzat ◽  
R. K. Dale ◽  
S. J. Lim ◽  
E. P. Lei
Keyword(s):  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Tissue Specific ◽  
Chromatin Insulator ◽  
Insulator Function ◽  
Specific Manner

436c Tissue-Specific Knockout of the RNA-Binding Protein HuR Inhibits Intestinal Mucosal Growth by Down-Regulating Wnt Signaling

2013 ◽  
Vol 144 (5) ◽  
pp. S-81
Author(s):  
Lan Liu ◽  
Mark ZQ Ma ◽  
Rena Shi ◽  
Rao N. Jaladanki ◽  
Lan Xiao ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Tissue Specific ◽  
Mucosal Growth

scholarly journals Constitutive Musashi1 expression impairs mouse postnatal development and intestinal homeostasis

2021 ◽  
Vol 32 (1) ◽  
pp. 28-44
Author(s):  
Thelma T. Chiremba ◽  
Kristi L. Neufeld
Keyword(s):  
Mouse Model ◽  
Postnatal Development ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Intestinal Homeostasis ◽  
Developmental Defects ◽  
Tissue Specific ◽  
Specific Effects

We report the generation of a versatile mouse model that facilitates Cre-inducible and tissue-specific overexpression of RNA-binding protein Musashi1. Ubiquitous overexpression resulted in postnatal developmental defects including shortened intestines. Alterations in intestinal size and differentiation indicated region-specific effects of Musashi1.

scholarly journals The Tissue-Specific RNA Binding Protein T-STAR Controls Regional Splicing Patterns of Neurexin Pre-mRNAs in the Brain

PLoS Genetics ◽  
2013 ◽  
Vol 9 (4) ◽  
pp. e1003474 ◽  
Author(s):  
Ingrid Ehrmann ◽  
Caroline Dalgliesh ◽  
Yilei Liu ◽  
Marina Danilenko ◽  
Moira Crosier ◽  
...  
Keyword(s):  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Tissue Specific ◽  
Splicing Patterns ◽  
The Brain

scholarly journals The Fox-1 Family and SUP-12 Coordinately Regulate Tissue-Specific Alternative Splicing In Vivo

2007 ◽  
Vol 27 (24) ◽  
pp. 8612-8621 ◽  
Author(s):  
Hidehito Kuroyanagi ◽  
Genta Ohno ◽  
Shohei Mitani ◽  
Masatoshi Hagiwara
Keyword(s):  
Alternative Splicing ◽  
Binding Proteins ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Stable Complex ◽  
Tissue Specific ◽  
Specific Alternative

ABSTRACT Many pre-mRNAs are alternatively spliced in a tissue-specific manner in multicellular organisms. The Fox-1 family of RNA-binding proteins regulate alternative splicing by either activating or repressing exon inclusion through specific binding to UGCAUG stretches. However, the precise cellular contexts that determine the action of the Fox-1 family in vivo remain to be elucidated. We have recently demonstrated that ASD-1 and FOX-1, members of the Fox-1 family in Caenorhabditis elegans, regulate tissue-specific alternative splicing of the fibroblast growth factor receptor gene, egl-15, which eventually determines the ligand specificity of the receptor in vivo. Here we report that another RNA-binding protein, SUP-12, coregulates the egl-15 alternative splicing. By screening for mutants defective in the muscle-specific expression of our alternative splicing reporter, we identified the muscle-specific RNA-binding protein SUP-12. We identified juxtaposed conserved stretches as the cis elements responsible for the regulation. The Fox-1 family and the SUP-12 proteins form a stable complex with egl-15 RNA, depending on the cis elements. Furthermore, the asd-1; sup-12 double mutant is defective in sex myoblast migration, phenocopying the isoform-specific egl-15(5A) mutant. These results establish an in vivo model that coordination of the two families of RNA-binding proteins regulates tissue-specific alternative splicing of a specific target gene.

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