scholarly journals Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission

Cell Reports ◽  
2020 ◽  
Vol 30 (6) ◽  
pp. 1883-1897.e6 ◽  
Author(s):  
Rajan Pandey ◽  
Steven Abel ◽  
Matthew Boucher ◽  
Richard J. Wall ◽  
Mohammad Zeeshan ◽  
...  
Keyword(s):  
Atypical Mitosis

Adrenocortical Carcinoma With Concomitant Myelolipoma in a Patient With Hyperaldosteronism

2005 ◽  
Vol 129 (6) ◽  
pp. e144-e147 ◽  
Author(s):  
Xichun Sun ◽  
Alberto Ayala ◽  
Claudia Y. Castro
Keyword(s):  
Adrenocortical Carcinoma ◽  
Severe Hypertension ◽  
Serum Potassium Level ◽  
Venous Invasion ◽  
Ki 67 ◽  
Unilateral Adrenalectomy ◽  
Aldosterone Level ◽  
Serum Aldosterone ◽  
Mitotic Figures ◽  
Atypical Mitosis

Abstract We present a case of aldosterone-secreting adrenocortical carcinoma with concomitant myelolipoma. To the best of our knowledge, this is the first such reported case. The patient was a 43-year-old man with severe hypertension. Clinical workup revealed an increased serum aldosterone level, hypokalemia, and metabolic alkalosis, and a left adrenal mass was found on computed tomography. The patient underwent a unilateral adrenalectomy, which led to improvement in blood pressure, the serum potassium level, and aldosterone concentration. The tumor weighed 70 g and measured 5.0 cm. On microscopic examination, we found necrosis, focal cytologic atypia, diffuse eosinophilic cells comprising more than 75% of the tumor, 5 to 7 mitotic figures per 50 high-power fields, rare atypical mitosis, and venous invasion. At the periphery of the tumor but within the capsule, microscopic areas of myelolipoma were seen. Ki-67 staining was positive in 20% of the tumor cells. Although rare, aldosterone-secreting carcinoma associated with myelolipoma should be included in the differential diagnosis of adrenal gland masses.

scholarly journals Anaplastic carcinoma of the thyroid - clinicomorphological spectrum and review of literature

1970 ◽  
Vol 1 (1) ◽  
pp. 45-48 ◽  
Author(s):  
A Ghosh ◽  
N Nepal ◽  
MD Gharti ◽  
S Basnet ◽  
M Baxi ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Spindle Cell ◽  
Neck Mass ◽  
Anaplastic Thyroid Carcinoma ◽  
Anaplastic Carcinoma ◽  
High Power Field ◽  
The Mean ◽  
Cell Variant ◽  
Thyroid Malignancies ◽  
Atypical Mitosis

Background: Thyroid cancer is fairly common. The worldwide annual incidence ranges from 0.5 to 10 cases per 100,000 people. Anaplastic thyroid carcinoma, comprising less than 10% of all thyroid carcinomas, remains one of the most virulent of all cancers in humans with a 10 year survival rate of only 0.1 %. In the present study we looked into the clinical, cytological and histological spectrum of anaplastic carcinoma and compared our experience with recent literature. Materials and Methods: This was a hospital based retrospective study from January 2000 to November 2010. Clinical, cytological and histopathological data of all the diagnosed anaplastic thyroid carcinoma cases were reviewed and analyzed. Results: Of the 59 thyroid malignancies diagnosed in the same period, 7 cases were anaplastic carcinoma. The mean age was 63 years and was predominantly found in females. All of the cases presented with a neck mass that lasted for a mean of 5.7 months. The mean tumor size was 14.9 cm and the most common sub-type was the spindle cell type. Atypical mitosis of more than 5 per high power field and necrosis was noted in all cases. Conclusion: Due to the markedly aggressive nature of this tumor and its association with areas of endemic thyroid disease, early diagnosis and aggressive therapy is essential, especially in the Himalayan and Sub-Himalayan belt. Keywords: Anaplastic carcinoma; Thyroid carcinoma; Spindle cell variant DOI: 10.3126/jpn.v1i1.4451 Journal of Pathology of Nepal (2011) Vol.1, 45-48

scholarly journals Cardiac Epithelioid PEComa: Report of Two Cases and Review of the Literature

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Huilin Niu ◽  
F. W. Wang ◽  
Paul J. Zhang ◽  
Zhanyong Bing
Keyword(s):  
Clear Cell ◽  
Coagulation Necrosis ◽  
Review Of The Literature ◽  
Epithelioid Cells ◽  
Adult Case ◽  
Pediatric Case ◽  
High Mitotic Activity ◽  
Atypical Mitosis ◽  
Malignant Behavior ◽  
Hmb 45

Cardiac PEComa is very rare. We reported two cases of epithelioid PEComas, one in an adult and one in a 2-year-old child. Both tumors were composed of sheets of epithelioid cells with coagulation necrosis. In addition, the adult case showed marked nuclear atypia and high mitotic activity with atypical mitosis and the pediatric case showed unusual clear cell features. Immunohistochemically, both tumors were positive for HMB-45 and SMA and negative for S100 and cytokeratin. Electron microscopy was performed in the pediatric case and showed premelanosomes. The adult patient developed extensive metastasis indicating malignant behavior. Prior to the two cases, only 5 other cases of cardiac PEComa were reported and the literatures are reviewed.

scholarly journals Author Correction: Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Richard J. Wall ◽  
David J. P. Ferguson ◽  
Aline Freville ◽  
Blandine Franke-Fayard ◽  
Declan Brady ◽  
...  
Keyword(s):  
Chromosome Condensation ◽  
Male Gametogenesis ◽  
Atypical Mitosis

scholarly journals CCNB2 and AURKA overexpression may cause atypical mitosis in Japanese cortisol-producing adrenocortical carcinoma with TP53 somatic variant

PLoS ONE ◽  
2020 ◽  
Vol 15 (4) ◽  
pp. e0231665
Author(s):  
Akira Ikeya ◽  
Mitsuko Nakashima ◽  
Miho Yamashita ◽  
Keisuke Kakizawa ◽  
Yuta Okawa ◽  
...  
Keyword(s):  
Adrenocortical Carcinoma ◽  
Somatic Variant ◽  
Atypical Mitosis

Malignant and Atypical Meningiomas: A Reappraisal of Clinical, Histological, and Computed Tomographic Features

Neurosurgery ◽  
1987 ◽  
Vol 20 (5) ◽  
pp. 688-694 ◽  
Author(s):  
Fernando Alvarez ◽  
José M. Roda ◽  
Mercedes Pérez Romero ◽  
Carmen Morales ◽  
Maria A. Sarmiento ◽  
...  
Keyword(s):  
Surgical Excision ◽  
Male Predominance ◽  
Computed Tomographic ◽  
Brain Substance ◽  
Histological Criteria ◽  
Poor Differentiation ◽  
High Cellularity ◽  
Atypical Meningiomas ◽  
The Brain ◽  
Atypical Mitosis

Abstract A series of 21 patients with atypical and malignant meningiomas is presented. Histological criteria such as high cellularity, typical and atypical mitosis, necrosis, infiltration of the underlying brain, poor differentiation, and distant metastasis define nonbenign meningiomas. Male predominance in this nonbenign group is significant when compared to a group of 205 benign meningiomas, which were also operated on. The malignant and atypical meningiomas are compared with the benign meningiomas, and special emphasis is placed on their computed tomographic features. The presence of tumor fringes (suggesting invasion of the brain substance) and intratumoral hypodense areas were both significant signs of malignancy of atypia. Radical surgical excision is still considered the treatment of choice.

scholarly journals Benign reactive lesion with atypical mitosis: New example of an old story

2014 ◽  
Vol 5 (3) ◽  
pp. 235
Author(s):  
Hua Zhong ◽  
Marina Chekmareva ◽  
Malik Deen ◽  
Michael May ◽  
Steven Deak ◽  
...  
Keyword(s):  
Atypical Mitosis

scholarly journals Useful histological findings in incisional biopsies of oral squamous cell carcinoma

2016 ◽  
Vol 144 (7-8) ◽  
pp. 384-390 ◽  
Author(s):  
Adna Ismerim ◽  
Flávia Xavier ◽  
Maria Cangussu ◽  
Luciana Ramalho ◽  
Ivan Agra ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Squamous Cell ◽  
Granulation Tissue ◽  
Vascular Invasion ◽  
Giant Cells ◽  
Tumor Thickness ◽  
Low Grade ◽  
High Grade ◽  
Atypical Mitosis

Introduction. Oral squamous cell carcinoma (OSCC) is one of the most common head and neck cancers. Objective. The aim of this study was to investigate the histopathological features of OSCC specimens obtained from incisional biopsies and to alert clinicians to the importance of more representative biopsies. Methods.. Forty-eight OSCC samples were obtained from incisional biopsies and classified by Bryne?s score. The following morphological features were analyzed: invasive front, invasiveness, apoptotic cells, atypical mitosis, giant cells, acantholysis, ulceration, necrosis, calcification, surface epithelium, granulation tissue, desmoplasia, tissue invasions, inflammatory infiltrate and tumor thickness. Results. Ten (21%) cases were classified as high grade malignancies and 38 (79%) as low grade. Apoptotic cells (n = 26), atypical mitosis (1-2/20?; n = 38), giant cells (n = 8), acantholysis (n = 5), necrosis (n = 5), calcification (n = 1), granulation tissue (n = 32), desmoplasia (n = 4), perineural invasion (n = 2), muscular invasion (n = 8), invasion of salivary gland tissue (n = 3), vascular invasion (n = 10), and chronic inflammation (n = 33) were observed. Vascular invasion (p = 0.04, Pearson?s ?2 test) and necrosis (p = 0.04, Pearson?s ?2 test) were significantly associated with cases of high-grade malignant tumors. Atypical mitosis was associated with a greatest tumor thickness (p = 0.04, Fischer?s exact test). Conclusion. This study suggests that incisional biopsies may be useful and significant as they can show histopathological variables that are important to classify oral squamous cell carcinomas into low grade and high grade according to Bryne?s score, which was used in this study. Thus, more representative biopsies might be useful to achieve this and allow a more accurate planning.

scholarly journals Upper gastrointestinal hemorrhage due to duodenal stromal tumor

2003 ◽  
Vol 40 (3) ◽  
pp. 188-191 ◽  
Author(s):  
José Gustavo Parreira ◽  
Wilson de Freitas ◽  
Samir Rasslan
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Hemorrhage ◽  
Emergency Service ◽  
Upper Gastrointestinal Bleeding ◽  
Stromal Tumor ◽  
Post Operative Period ◽  
Heater Probe ◽  
Median Laparotomy ◽  
Upper Gastrointestinal ◽  
Atypical Mitosis

BACKGROUND: Gastrointestinal stromal tumor represents a rare neoplasm that originates in the muscular wall of the hollow viscera. AIM: To report gastrointestinal stromal tumor as a source of upper gastrointestinal bleeding, which required urgent surgical control. PATIENT/METHOD: A man with 61 years old was admitted to the emergency service sustaining hematemesis and melena. Endoscopy showed active bleeding from a tumor in the second portion of the duodenum, which was controlled by heater probe cauterization. Surgery was performed through a median laparotomy. A local resection of a 4 cm tumor in the second portion of the duodenum was carried out, together with a primary end-to-end anastomosis and a duodenal diverticulization. No complications happened during the post-operative period. Morphologic examination showed gastrointestinal stromal tumor with no atypical mitosis and a preserved capsule. CONCLUSION: Albeit not being common, gastrointestinal stromal tumors can represent a source of substantial gastrointestinal hemorrhage.

Sign in / Sign up

Export Citation Format

Share Document