scholarly journals The Probability of Neurotransmitter Release Governs AMPA Receptor Trafficking via Activity-Dependent Regulation of mGluR1 Surface Expression

Cell Reports ◽  
2018 ◽  
Vol 25 (13) ◽  
pp. 3631-3646.e3 ◽  
Author(s):  
Thomas M. Sanderson ◽  
Clarrisa A. Bradley ◽  
John Georgiou ◽  
Yun Hwa Hong ◽  
Ai Na Ng ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Neurotransmitter Release ◽  
Surface Expression ◽  
Receptor Trafficking ◽  
Activity Dependent ◽  
Ampa Receptor Trafficking

scholarly journals Activity-dependent PI(3,5)P2synthesis controls AMPA receptor trafficking during synaptic depression

2014 ◽  
Vol 111 (45) ◽  
pp. E4896-E4905 ◽  
Author(s):  
Amber J. McCartney ◽  
Sergey N. Zolov ◽  
Emily J. Kauffman ◽  
Yanling Zhang ◽  
Bethany S. Strunk ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Synaptic Depression ◽  
Receptor Trafficking ◽  
Activity Dependent ◽  
Ampa Receptor Trafficking

scholarly journals AMPA receptor trafficking and long-term potentiation

2003 ◽  
Vol 358 (1432) ◽  
pp. 707-714 ◽  
Author(s):  
Roberto Malinow
Keyword(s):  
Ampa Receptor ◽  
Critical Role ◽  
Long Term Potentiation ◽  
Receptor Trafficking ◽  
Synaptic Function ◽  
Term Potentiation ◽  
The Subject ◽  
Activity Dependent ◽  
Ampa Receptor Trafficking

Activity-dependent changes in synaptic function are believed to underlie the formation of memories. A prominent example is long-term potentiation (LTP), whose mechanisms have been the subject of considerable scrutiny over the past few decades. I review studies from our laboratory that support a critical role for AMPA receptor trafficking in LTP and experience-dependent plasticity.

PKMζ maintains memories by regulating GluR2-dependent AMPA receptor trafficking

2010 ◽  
Vol 13 (5) ◽  
pp. 630-634 ◽  
Author(s):  
Paola Virginia Migues ◽  
Oliver Hardt ◽  
Dong Chuan Wu ◽  
Karine Gamache ◽  
Todd Charlton Sacktor ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Receptor Trafficking ◽  
Ampa Receptor Trafficking

scholarly journals Structural and functional brain-wide alterations in A350V Iqsec2 mutant mice displaying autistic-like behavior

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Daniela Lichtman ◽  
Eyal Bergmann ◽  
Alexandra Kavushansky ◽  
Nadav Cohen ◽  
Nina S. Levy ◽  
...  
Keyword(s):  
Social Behavior ◽  
Functional Connectivity ◽  
Mouse Model ◽  
Ampa Receptor ◽  
Social Preference ◽  
Autism Spectrum ◽  
Receptor Trafficking ◽  
Anterior Cingulate ◽  
The Impact ◽  
Ampa Receptor Trafficking

AbstractIQSEC2 is an X-linked gene that is associated with autism spectrum disorder (ASD), intellectual disability, and epilepsy. IQSEC2 is a postsynaptic density protein, localized on excitatory synapses as part of the NMDA receptor complex and is suggested to play a role in AMPA receptor trafficking and mediation of long-term depression. Here, we present brain-wide structural volumetric and functional connectivity characterization in a novel mouse model with a missense mutation in the IQ domain of IQSEC2 (A350V). Using high-resolution structural and functional MRI, we show that animals with the A350V mutation display increased whole-brain volume which was further found to be specific to the cerebral cortex and hippocampus. Moreover, using a data-driven approach we identify putative alterations in structure–function relations of the frontal, auditory, and visual networks in A350V mice. Examination of these alterations revealed an increase in functional connectivity between the anterior cingulate cortex and the dorsomedial striatum. We also show that corticostriatal functional connectivity is correlated with individual variability in social behavior only in A350V mice, as assessed using the three-chamber social preference test. Our results at the systems-level bridge the impact of previously reported changes in AMPA receptor trafficking to network-level disruption and impaired social behavior. Further, the A350V mouse model recapitulates similarly reported brain-wide changes in other ASD mouse models, with substantially different cellular-level pathologies that nonetheless result in similar brain-wide alterations, suggesting that novel therapeutic approaches in ASD that result in systems-level rescue will be relevant to IQSEC2 mutations.

Stress hormones and AMPA receptor trafficking in synaptic plasticity and memory

2010 ◽  
Vol 11 (10) ◽  
pp. 675-681 ◽  
Author(s):  
Harmen J. Krugers ◽  
Casper C. Hoogenraad ◽  
Laurent Groc
Keyword(s):  
Synaptic Plasticity ◽  
Ampa Receptor ◽  
Stress Hormones ◽  
Receptor Trafficking ◽  
Ampa Receptor Trafficking
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