PKMζ maintains memories by regulating GluR2-dependent AMPA receptor trafficking

2010 ◽  
Vol 13 (5) ◽  
pp. 630-634 ◽  
Author(s):  
Paola Virginia Migues ◽  
Oliver Hardt ◽  
Dong Chuan Wu ◽  
Karine Gamache ◽  
Todd Charlton Sacktor ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Receptor Trafficking ◽  
Ampa Receptor Trafficking

scholarly journals Structural and functional brain-wide alterations in A350V Iqsec2 mutant mice displaying autistic-like behavior

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Daniela Lichtman ◽  
Eyal Bergmann ◽  
Alexandra Kavushansky ◽  
Nadav Cohen ◽  
Nina S. Levy ◽  
...  
Keyword(s):  
Social Behavior ◽  
Functional Connectivity ◽  
Mouse Model ◽  
Ampa Receptor ◽  
Social Preference ◽  
Autism Spectrum ◽  
Receptor Trafficking ◽  
Anterior Cingulate ◽  
The Impact ◽  
Ampa Receptor Trafficking

AbstractIQSEC2 is an X-linked gene that is associated with autism spectrum disorder (ASD), intellectual disability, and epilepsy. IQSEC2 is a postsynaptic density protein, localized on excitatory synapses as part of the NMDA receptor complex and is suggested to play a role in AMPA receptor trafficking and mediation of long-term depression. Here, we present brain-wide structural volumetric and functional connectivity characterization in a novel mouse model with a missense mutation in the IQ domain of IQSEC2 (A350V). Using high-resolution structural and functional MRI, we show that animals with the A350V mutation display increased whole-brain volume which was further found to be specific to the cerebral cortex and hippocampus. Moreover, using a data-driven approach we identify putative alterations in structure–function relations of the frontal, auditory, and visual networks in A350V mice. Examination of these alterations revealed an increase in functional connectivity between the anterior cingulate cortex and the dorsomedial striatum. We also show that corticostriatal functional connectivity is correlated with individual variability in social behavior only in A350V mice, as assessed using the three-chamber social preference test. Our results at the systems-level bridge the impact of previously reported changes in AMPA receptor trafficking to network-level disruption and impaired social behavior. Further, the A350V mouse model recapitulates similarly reported brain-wide changes in other ASD mouse models, with substantially different cellular-level pathologies that nonetheless result in similar brain-wide alterations, suggesting that novel therapeutic approaches in ASD that result in systems-level rescue will be relevant to IQSEC2 mutations.

Stress hormones and AMPA receptor trafficking in synaptic plasticity and memory

2010 ◽  
Vol 11 (10) ◽  
pp. 675-681 ◽  
Author(s):  
Harmen J. Krugers ◽  
Casper C. Hoogenraad ◽  
Laurent Groc
Keyword(s):  
Synaptic Plasticity ◽  
Ampa Receptor ◽  
Stress Hormones ◽  
Receptor Trafficking ◽  
Ampa Receptor Trafficking

scholarly journals Presynaptic Neurexin-3 Alternative Splicing trans-Synaptically Controls Postsynaptic AMPA Receptor Trafficking

Cell ◽  
2013 ◽  
Vol 154 (1) ◽  
pp. 75-88 ◽  
Author(s):  
Jason Aoto ◽  
David C. Martinelli ◽  
Robert C. Malenka ◽  
Katsuhiko Tabuchi ◽  
Thomas C. Südhof
Keyword(s):  
Alternative Splicing ◽  
Ampa Receptor ◽  
Receptor Trafficking ◽  
Ampa Receptor Trafficking

scholarly journals A role for cGMP-dependent protein kinase II in AMPA receptor trafficking and synaptic plasticity

2009 ◽  
Vol 9 (Suppl 1) ◽  
pp. S44 ◽  
Author(s):  
Yafelle Serulle ◽  
Ipe Ninan ◽  
Daniela Puzzo ◽  
Maria McCarthy ◽  
Latika Khatri ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Protein Kinase ◽  
Ampa Receptor ◽  
Receptor Trafficking ◽  
Dependent Protein Kinase ◽  
Cgmp Dependent Protein Kinase ◽  
Protein Kinase Ii ◽  
Dependent Protein ◽  
Ampa Receptor Trafficking
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