scholarly journals Metabolic Damage and Premature Thymus Aging Caused by Stromal Catalase Deficiency

Cell Reports ◽  
2015 ◽  
Vol 12 (7) ◽  
pp. 1071-1079 ◽  
Author(s):  
Ann V. Griffith ◽  
Thomas Venables ◽  
Jianjun Shi ◽  
Andrew Farr ◽  
Holly van Remmen ◽  
...  
Keyword(s):  
Catalase Deficiency

scholarly journals Catalase deficiency renders remnant kidneys more susceptible to oxidant tissue injury and renal fibrosis in mice

2005 ◽  
Vol 68 (3) ◽  
pp. 1018-1031 ◽  
Author(s):  
Mizuho Kobayashi ◽  
Hitoshi Sugiyama ◽  
Da-Hong Wang ◽  
Naomi Toda ◽  
Yohei Maeshima ◽  
...  
Keyword(s):  
Renal Fibrosis ◽  
Tissue Injury ◽  
Catalase Deficiency

scholarly journals Peroxisomal catalase deficiency modulates yeast lifespan depending on growth conditions

Aging ◽  
2013 ◽  
Vol 5 (1) ◽  
pp. 67-83 ◽  
Author(s):  
Adam Kawałek ◽  
Sophie D. Lefevre ◽  
Marten Veenhuis ◽  
Ida J. van der Klei
Keyword(s):  
Growth Conditions ◽  
Catalase Deficiency

Detection of a novel familial catalase mutation (Hungarian type D) and the possible risk of inherited catalase deficiency for diabetes mellitus

2005 ◽  
Vol 26 (9) ◽  
pp. 1646-1649 ◽  
Author(s):  
László Góth ◽  
Márta Vitai ◽  
Péter Rass ◽  
Eszter Sükei ◽  
Anikó Páy
Keyword(s):  
Diabetes Mellitus ◽  
Type D ◽  
Catalase Deficiency

scholarly journals Acatalasemia sensitizes renal tubular epithelial cells to apoptosis and exacerbates renal fibrosis after unilateral ureteral obstruction

2004 ◽  
Vol 286 (6) ◽  
pp. F1030-F1038 ◽  
Author(s):  
Reiko Sunami ◽  
Hitoshi Sugiyama ◽  
Da-Hong Wang ◽  
Mizuho Kobayashi ◽  
Yohei Maeshima ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Ureteral Obstruction ◽  
Interstitial Fibrosis ◽  
Mitochondrial Pathway ◽  
Protective Role ◽  
Unilateral Ureteral Obstruction ◽  
Tubular Epithelial Cells ◽  
Wild Type ◽  
Tubulointerstitial Injury ◽  
Catalase Deficiency

Tissue homeostasis is determined by the balance between oxidants and antioxidants. Catalase is an important antioxidant enzyme regulating the level of intracellular hydrogen peroxide and hydroxyl radicals. The effect of catalase deficiency on renal tubulointerstitial injury induced by unilateral ureteral obstruction (UUO) has been studied in homozygous acatalasemic mutant mice (C3H/AnLCsbCsb) compared with wild-type mice (C3H/AnLCsaCsa). Complete UUO caused interstitial cell infiltration, tubular dilation and atrophy, and interstitial fibrosis with accumulation of type IV collagen in obstructed kidneys (OBK) of both mouse groups. However, the degree of injury showed a significant increase in OBK of acatalasemic mice compared with that of wild-type mice until day 7. The deposition of lipid peroxidation products including 4-hydroxy-2-hexenal, malondialdehyde, and 4-hydroxy-2-nonenal was severer in dilated tubules of acatalasemic OBK. Apoptosis in tubular epithelial cells significantly increased in acatalasemic OBK at day 4. Expression of caspase-9, a marker of mitochondrial pathway-derived apoptosis, increased in dilated tubules of acatalasemic mice. The level of catalase activity remained low in acatalasemic OBK until day 7 without compensatory upregulation of glutathione peroxidase activity. The data indicate that acatalasemia exacerbated oxidation of renal tissue and sensitized tubular epithelial cells to apoptosis in OBK of UUO. This study demonstrates that catalase deficiency enhanced tubulointerstitial injury and fibrosis in a murine model of UUO and thus supports the protective role of catalase in this model.

scholarly journals Catalase Deficiency and Type 2 Diabetes

Diabetes Care ◽  
2008 ◽  
Vol 31 (12) ◽  
pp. e93-e93 ◽  
Author(s):  
L. Goth
Keyword(s):  
Type 2 Diabetes ◽  
Catalase Deficiency

Catalase deficiency may complicate urate oxidase (rasburicase) therapy

2007 ◽  
Vol 41 (9) ◽  
pp. 953-955 ◽  
Author(s):  
László Góth ◽  
N. William Bigler
Keyword(s):  
Urate Oxidase ◽  
Catalase Deficiency
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