Detection of a novel familial catalase mutation (Hungarian type D) and the possible risk of inherited catalase deficiency for diabetes mellitus

2005 ◽  
Vol 26 (9) ◽  
pp. 1646-1649 ◽  
Author(s):  
László Góth ◽  
Márta Vitai ◽  
Péter Rass ◽  
Eszter Sükei ◽  
Anikó Páy
2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Xuemei Li ◽  
Min Gao ◽  
Shengfa Zhang ◽  
Huiwen Xu ◽  
Huixuan Zhou ◽  
...  

Aims. To examine the association between Type D personality and HbA1c level and to explore the mediating role of medication adherence between them in patients with type 2 diabetes mellitus (T2DM).Methods. 330 patients went on to complete a self-report measure of medication adherence and the HbA1c tests. Chi-square test,Ttest, Ordinary Least Square Regression (OLS), and Recentered Influence Function Regression (RIF) were employed.Results. Patients with Type D personality had significantly higher HbA1c value (P<0.01). When Type D personality was operationalized as a categorical variable, SI was associated with HbA1c (P<0.01). When NA, SI, and their interaction term were entered into regression, all of them were no longer associated with HbA1c level (P>0.1). On the other hand, when Type D personality was operationalized as a continuous variable, only SI trait was associated with HbA1c level (P<0.01). When NA, SI, andNA×SIterm together were entered into regression, only SI was not related to HbA1c level. Furthermore, medication adherence had a significant mediation effect between Type D personality and HbA1c, accounting for 54.43% of the total effect.Conclusion. Type D personality was associated with HbA1c in direct and indirect ways, and medication adherence acted as a mediator role.


2020 ◽  
Author(s):  
Yi-Hsin Lin ◽  
Di-An Chen ◽  
Chemin Lin ◽  
Hsuan Huang

Abstract The authors have withdrawn this preprint from Research Square


2017 ◽  
Vol 41 (S1) ◽  
pp. S491-S492
Author(s):  
V.R. Enatescu ◽  
I. Papava ◽  
R.S. Romosan ◽  
A. Grozavu ◽  
V. Enatescu ◽  
...  

IntroductionIn 2015, the worldwide point prevalence for diabetes mellitus was 8.8%. Type D personality was found as being more prevalent in type 2 diabetes than in the general population.ObjectivesWe aimed to reveal the frequency of type D personality and to analyze the impact of type D personality on both quality of life and angiopathic complications, in patients with type 2 diabetes from our region.MethodsA cross-sectional research was performed on 79 outpatients that were monitored for diabetes mellitus at Timisoara diabetes, nutrition and metabolic diseases clinic. Type D personality was assessed with the DS-14 scale. Quality of life was quantified by using the Q-LES-Q-SF scale (Quality of Life Enjoyment and Satisfaction Questionnaire-Short Form). The angiopathic complications were abstracted from medical records.ResultsType D personality was present in 38 subjects with diabetes mellitus (48.10%). Compared to those without type D personality, patients with type D personality and diabetes had significant lower mean scores for the following domains of the Q-LES-Q-SF scale: social relationships (P < 0.001), daily life function (P = 0.027), sexual activity (P = 0.005), to get around physically (P < 0.001), work or hobbies (P = 0.008) and raw score (P = 0.003). Type D personality did not make any difference regarding micro and macroangiopathic complications of type 2 diabetes patients.ConclusionsType D personality, a highly frequent entity, did not make the difference with respect to diabetic complications; however, it may interfere significantly with several facets of the quality of life of these patients. These results should be taken into account for an interdisciplinary approach to these patients.Disclosure of interestThe authors have not supplied their declaration of competing interest.


2020 ◽  
Author(s):  
Yi-Hsin Lin ◽  
Di-An Chen ◽  
Chemin Lin ◽  
Hsuan Huang

Abstract Background: Type D personality (TDP) has been recognized as a risk factor for many diseases. Researches in association with TDP and type 2 diabetes mellitus (T2DM) were limited. Aims: The aim of this study was to estimate the prevalence of TDP, also to assess the relationship between TDP and perceived stress, self-efficacy, self-care behaviors, and psychological distress on Taiwanese patients with T2DM.Methods: 198 patients with T2DM were recruited consecutively from the department of endocrinology of a regional hospital in Taipei, Taiwan from December 2017 to April 2018. The participants completed questionnaires containing questions about sociodemographic characteristics, TDP, illness-related stress, self-efficacy, execution of diabetes management and emotional distress. Their medical records were reviewed for biomedical data.Results: 41.4% of the 198 patients had TDP. Controlling for sociodemographic factors, patients with TDP were reported significantly poorer on glycemic control than those without this personality (P<0.05). Compared to those without TDP, the results showed significantly higher levels of perceived stress (P<0.001) and psychological distress (anxiety and depression) (P<0.001), as well as significantly lower levels of self-efficacy (P<0.001) and self-care behaviors (P<0.001) on patients with TDP. TDP is positively correlated with perceived stress and psychological distress. It is negatively correlated with self-efficacy and self-care behavior scores.Discussion: This study provides the evidence linking TDP with poor glycemic control, self-efficacy, and self-care behaviors, as well as high perceived stress and psychological distress, which highlights the screening of TDP and the specific needs for the care among T2DM patients with TDP.


1998 ◽  
Vol 39 (5) ◽  
pp. 663-668 ◽  
Author(s):  
Harry N. Bawden ◽  
Aidan Stokes ◽  
Carol S. Camfield ◽  
Peter R. Camfield ◽  
Sonia Salisbury

Author(s):  
Bruce R. Pachter

Diabetes mellitus is one of the commonest causes of neuropathy. Diabetic neuropathy is a heterogeneous group of neuropathic disorders to which patients with diabetes mellitus are susceptible; more than one kind of neuropathy can frequently occur in the same individual. Abnormalities are also known to occur in nearly every anatomic subdivision of the eye in diabetic patients. Oculomotor palsy appears to be common in diabetes mellitus for their occurrence in isolation to suggest diabetes. Nerves to the external ocular muscles are most commonly affected, particularly the oculomotor or third cranial nerve. The third nerve palsy of diabetes is characteristic, being of sudden onset, accompanied by orbital and retro-orbital pain, often associated with complete involvement of the external ocular muscles innervated by the nerve. While the human and experimental animal literature is replete with studies on the peripheral nerves in diabetes mellitus, there is but a paucity of reported studies dealing with the oculomotor nerves and their associated extraocular muscles (EOMs).


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