scholarly journals An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

Cell ◽  
2015 ◽  
Vol 162 (3) ◽  
pp. 540-551 ◽  
Author(s):  
Kıvanç Birsoy ◽  
Tim Wang ◽  
Walter W. Chen ◽  
Elizaveta Freinkman ◽  
Monther Abu-Remaileh ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Electron Transport ◽  
Electron Transport Chain ◽  
Essential Role ◽  
Mitochondrial Electron Transport Chain ◽  
Transport Chain

Double-edged sword in cells: chemical biology studies of the vital role of cytochrome c in the intrinsic pre-apoptotic mitochondria leakage pathway

RSC Advances ◽  
2015 ◽  
Vol 5 (36) ◽  
pp. 28258-28269 ◽  
Author(s):  
Zhi-Peng Wang ◽  
Xiao-Zhe Ding ◽  
Jun Wang ◽  
Yi-Ming Li
Keyword(s):  
Cell Death ◽  
Electron Transport ◽  
Cytochrome C ◽  
Electron Transport Chain ◽  
Chemical Biology ◽  
Vital Role ◽  
Mitochondrial Electron Transport Chain ◽  
Transport Chain ◽  
Cyt C

Besides functioning as an electron transporter in the mitochondrial electron transport chain, cytochrome c (cyt c) is also one of the determinants in the execution of cell death.

Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain

Science ◽  
2013 ◽  
Vol 340 (6140) ◽  
pp. 1567-1570 ◽  
Author(s):  
Esther Lapuente-Brun ◽  
Raquel Moreno-Loshuertos ◽  
Rebeca Acín-Pérez ◽  
Ana Latorre-Pellicer ◽  
Carmen Colás ◽  
...  
Keyword(s):  
Electron Transport ◽  
Electron Transport Chain ◽  
Electron Flux ◽  
Fluid Model ◽  
Coenzyme Q ◽  
Mitochondrial Electron Transport Chain ◽  
C Pools ◽  
Transport Chain ◽  
Cyt C

The textbook description of mitochondrial respiratory complexes (RCs) views them as free-moving entities linked by the mobile carriers coenzyme Q (CoQ) and cytochrome c (cyt c). This model (known as the fluid model) is challenged by the proposal that all RCs except complex II can associate in supercomplexes (SCs). The proposed SCs are the respirasome (complexes I, III, and IV), complexes I and III, and complexes III and IV. The role of SCs is unclear, and their existence is debated. By genetic modulation of interactions between complexes I and III and III and IV, we show that these associations define dedicated CoQ and cyt c pools and that SC assembly is dynamic and organizes electron flux to optimize the use of available substrates.

Sign in / Sign up

Export Citation Format

Share Document