Double-edged sword in cells: chemical biology studies of the vital role of cytochrome c in the intrinsic pre-apoptotic mitochondria leakage pathway

RSC Advances ◽  
2015 ◽  
Vol 5 (36) ◽  
pp. 28258-28269 ◽  
Author(s):  
Zhi-Peng Wang ◽  
Xiao-Zhe Ding ◽  
Jun Wang ◽  
Yi-Ming Li
Keyword(s):  
Cell Death ◽  
Electron Transport ◽  
Cytochrome C ◽  
Electron Transport Chain ◽  
Chemical Biology ◽  
Vital Role ◽  
Mitochondrial Electron Transport Chain ◽  
Transport Chain ◽  
Cyt C

Besides functioning as an electron transporter in the mitochondrial electron transport chain, cytochrome c (cyt c) is also one of the determinants in the execution of cell death.

Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain

Science ◽  
2013 ◽  
Vol 340 (6140) ◽  
pp. 1567-1570 ◽  
Author(s):  
Esther Lapuente-Brun ◽  
Raquel Moreno-Loshuertos ◽  
Rebeca Acín-Pérez ◽  
Ana Latorre-Pellicer ◽  
Carmen Colás ◽  
...  
Keyword(s):  
Electron Transport ◽  
Electron Transport Chain ◽  
Electron Flux ◽  
Fluid Model ◽  
Coenzyme Q ◽  
Mitochondrial Electron Transport Chain ◽  
C Pools ◽  
Transport Chain ◽  
Cyt C

The textbook description of mitochondrial respiratory complexes (RCs) views them as free-moving entities linked by the mobile carriers coenzyme Q (CoQ) and cytochrome c (cyt c). This model (known as the fluid model) is challenged by the proposal that all RCs except complex II can associate in supercomplexes (SCs). The proposed SCs are the respirasome (complexes I, III, and IV), complexes I and III, and complexes III and IV. The role of SCs is unclear, and their existence is debated. By genetic modulation of interactions between complexes I and III and III and IV, we show that these associations define dedicated CoQ and cyt c pools and that SC assembly is dynamic and organizes electron flux to optimize the use of available substrates.

A highly sensitive fluorescence biosensor for the detection of cytochrome c based on polydopamine nanotubes and exonuclease I amplification

2021 ◽  
Author(s):  
yanmei shen ◽  
Xueping Shen ◽  
Jia Ge ◽  
Lingbo Qu ◽  
Zhaohui Li
Keyword(s):  
Electron Transport ◽  
Cytochrome C ◽  
Cell Apoptosis ◽  
Electron Transport Chain ◽  
Mitochondrial Electron Transport Chain ◽  
Exonuclease I ◽  
Transport Chain ◽  
Highly Sensitive ◽  
Cyt C ◽  
Fluorescence Biosensor

Cytochrome c (Cyt c), as an important biomarker, plays an important role in cell apoptosis and mitochondrial electron transport chain. Here, we have developed a novel biosensor for the Cyt...

scholarly journals Vanadium Dioxide Nanocoating Induces Tumor Cell Death through Mitochondrial Electron Transport Chain Interruption

2018 ◽  
Vol 3 (3) ◽  
pp. 1800058 ◽  
Author(s):  
Jinhua Li ◽  
Meng Jiang ◽  
Huaijuan Zhou ◽  
Ping Jin ◽  
Kenneth M. C. Cheung ◽  
...  
Keyword(s):  
Cell Death ◽  
Electron Transport ◽  
Tumor Cell ◽  
Vanadium Dioxide ◽  
Electron Transport Chain ◽  
Mitochondrial Electron Transport Chain ◽  
Tumor Cell Death ◽  
Transport Chain
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