scholarly journals Axon Guidance of Mouse Olfactory Sensory Neurons by Odorant Receptors and the β2 Adrenergic Receptor

Cell ◽  
2004 ◽  
Vol 117 (6) ◽  
pp. 833-846 ◽  
Author(s):  
Paul Feinstein ◽  
Thomas Bozza ◽  
Ivan Rodriguez ◽  
Anne Vassalli ◽  
Peter Mombaerts
Keyword(s):  
Axon Guidance ◽  
Sensory Neurons ◽  
Adrenergic Receptor ◽  
Odorant Receptors ◽  
Olfactory Sensory Neurons ◽  
Β2 Adrenergic Receptor

Odorant Receptors in the Formation of the Olfactory Bulb Circuitry

Physiology ◽  
2012 ◽  
Vol 27 (4) ◽  
pp. 200-212 ◽  
Author(s):  
Claudia Lodovichi ◽  
Leonardo Belluscio
Keyword(s):  
Olfactory Bulb ◽  
Axon Guidance ◽  
Sensory Neurons ◽  
Odorant Receptors ◽  
Olfactory Sensory Neurons ◽  
Neural Connectivity ◽  
Axon Terminals ◽  
Primary Function

In mammals, smell is mediated by odorant receptors expressed by sensory neurons in the nose. These specialized receptors are found both on olfactory sensory neurons' cilia and axon terminals. Although the primary function of ciliary odorant receptors is to detect odorants, their axonal role remains unclear but is thought to involve axon guidance. This review discusses findings that show axonal odorant receptors are indeed functional and capable of modulating neural connectivity.

scholarly journals G protein-coupled odorant receptors underlie mechanosensitivity in mammalian olfactory sensory neurons

2014 ◽  
Vol 112 (2) ◽  
pp. 590-595 ◽  
Author(s):  
Timothy Connelly ◽  
Yiqun Yu ◽  
Xavier Grosmaitre ◽  
Jue Wang ◽  
Lindsey C. Santarelli ◽  
...  
Keyword(s):  
G Protein ◽  
Sensory Neurons ◽  
Ectopic Expression ◽  
Host Cells ◽  
Odorant Receptors ◽  
Olfactory Sensory Neurons ◽  
Mechanical Stimuli ◽  
Genetic Ablation ◽  
Mechanical Responses ◽  
G Protein Coupled

Mechanosensitive cells are essential for organisms to sense the external and internal environments, and a variety of molecules have been implicated as mechanical sensors. Here we report that odorant receptors (ORs), a large family of G protein-coupled receptors, underlie the responses to both chemical and mechanical stimuli in mouse olfactory sensory neurons (OSNs). Genetic ablation of key signaling proteins in odor transduction or disruption of OR–G protein coupling eliminates mechanical responses. Curiously, OSNs expressing different OR types display significantly different responses to mechanical stimuli. Genetic swap of putatively mechanosensitive ORs abolishes or reduces mechanical responses of OSNs. Furthermore, ectopic expression of an OR restores mechanosensitivity in loss-of-function OSNs. Lastly, heterologous expression of an OR confers mechanosensitivity to its host cells. These results indicate that certain ORs are both necessary and sufficient to cause mechanical responses, revealing a previously unidentified mechanism for mechanotransduction.

scholarly journals Expression Patterns of Odorant Receptors and Response Properties of Olfactory Sensory Neurons in Aged Mice

2009 ◽  
Vol 34 (8) ◽  
pp. 695-703 ◽  
Author(s):  
Anderson C. Lee ◽  
Huikai Tian ◽  
Xavier Grosmaitre ◽  
Minghong Ma
Keyword(s):  
Sensory Neurons ◽  
Expression Patterns ◽  
Odorant Receptors ◽  
Olfactory Sensory Neurons ◽  
Response Properties ◽  
Aged Mice

scholarly journals Mapping of Class I and Class II Odorant Receptors to Glomerular Domains by Two Distinct Types of Olfactory Sensory Neurons in the Mouse

Neuron ◽  
2009 ◽  
Vol 61 (2) ◽  
pp. 220-233 ◽  
Author(s):  
Thomas Bozza ◽  
Anne Vassalli ◽  
Stefan Fuss ◽  
Jing-Ji Zhang ◽  
Brian Weiland ◽  
...  
Keyword(s):  
Sensory Neurons ◽  
Class Ii ◽  
Class I ◽  
Odorant Receptors ◽  
Olfactory Sensory Neurons
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