Odorant responsiveness of embryonic mouse olfactory sensory neurons expressing the odorant receptors S1 or MOR23

2013 ◽  
Vol 38 (2) ◽  
pp. 2210-2217 ◽  
Author(s):  
Rebecca S. Lam ◽  
Peter Mombaerts
Keyword(s):  
Sensory Neurons ◽  
Odorant Receptors ◽  
Olfactory Sensory Neurons ◽  
Embryonic Mouse

scholarly journals G protein-coupled odorant receptors underlie mechanosensitivity in mammalian olfactory sensory neurons

2014 ◽  
Vol 112 (2) ◽  
pp. 590-595 ◽  
Author(s):  
Timothy Connelly ◽  
Yiqun Yu ◽  
Xavier Grosmaitre ◽  
Jue Wang ◽  
Lindsey C. Santarelli ◽  
...  
Keyword(s):  
G Protein ◽  
Sensory Neurons ◽  
Ectopic Expression ◽  
Host Cells ◽  
Odorant Receptors ◽  
Olfactory Sensory Neurons ◽  
Mechanical Stimuli ◽  
Genetic Ablation ◽  
Mechanical Responses ◽  
G Protein Coupled

Mechanosensitive cells are essential for organisms to sense the external and internal environments, and a variety of molecules have been implicated as mechanical sensors. Here we report that odorant receptors (ORs), a large family of G protein-coupled receptors, underlie the responses to both chemical and mechanical stimuli in mouse olfactory sensory neurons (OSNs). Genetic ablation of key signaling proteins in odor transduction or disruption of OR–G protein coupling eliminates mechanical responses. Curiously, OSNs expressing different OR types display significantly different responses to mechanical stimuli. Genetic swap of putatively mechanosensitive ORs abolishes or reduces mechanical responses of OSNs. Furthermore, ectopic expression of an OR restores mechanosensitivity in loss-of-function OSNs. Lastly, heterologous expression of an OR confers mechanosensitivity to its host cells. These results indicate that certain ORs are both necessary and sufficient to cause mechanical responses, revealing a previously unidentified mechanism for mechanotransduction.

scholarly journals Expression Patterns of Odorant Receptors and Response Properties of Olfactory Sensory Neurons in Aged Mice

2009 ◽  
Vol 34 (8) ◽  
pp. 695-703 ◽  
Author(s):  
Anderson C. Lee ◽  
Huikai Tian ◽  
Xavier Grosmaitre ◽  
Minghong Ma
Keyword(s):  
Sensory Neurons ◽  
Expression Patterns ◽  
Odorant Receptors ◽  
Olfactory Sensory Neurons ◽  
Response Properties ◽  
Aged Mice

Odorant Receptors in the Formation of the Olfactory Bulb Circuitry

Physiology ◽  
2012 ◽  
Vol 27 (4) ◽  
pp. 200-212 ◽  
Author(s):  
Claudia Lodovichi ◽  
Leonardo Belluscio
Keyword(s):  
Olfactory Bulb ◽  
Axon Guidance ◽  
Sensory Neurons ◽  
Odorant Receptors ◽  
Olfactory Sensory Neurons ◽  
Neural Connectivity ◽  
Axon Terminals ◽  
Primary Function

In mammals, smell is mediated by odorant receptors expressed by sensory neurons in the nose. These specialized receptors are found both on olfactory sensory neurons' cilia and axon terminals. Although the primary function of ciliary odorant receptors is to detect odorants, their axonal role remains unclear but is thought to involve axon guidance. This review discusses findings that show axonal odorant receptors are indeed functional and capable of modulating neural connectivity.

scholarly journals Mapping of Class I and Class II Odorant Receptors to Glomerular Domains by Two Distinct Types of Olfactory Sensory Neurons in the Mouse

Neuron ◽  
2009 ◽  
Vol 61 (2) ◽  
pp. 220-233 ◽  
Author(s):  
Thomas Bozza ◽  
Anne Vassalli ◽  
Stefan Fuss ◽  
Jing-Ji Zhang ◽  
Brian Weiland ◽  
...  
Keyword(s):  
Sensory Neurons ◽  
Class Ii ◽  
Class I ◽  
Odorant Receptors ◽  
Olfactory Sensory Neurons

scholarly journals Expressing exogenous functional odorant receptors in cultured olfactory sensory neurons

2008 ◽  
Vol 3 (1) ◽  
pp. 22 ◽  
Author(s):  
Huaiyang Chen ◽  
Sepehr Dadsetan ◽  
Alla F Fomina ◽  
Qizhi Gong
Keyword(s):  
Sensory Neurons ◽  
Odorant Receptors ◽  
Olfactory Sensory Neurons

scholarly journals Immature olfactory sensory neurons provide behaviorally useful sensory input to the olfactory bulb

2021 ◽  
Author(s):  
Jane S Huang ◽  
Tenzin Kunkhyen ◽  
Beichen Liu ◽  
Ryan J Muggleton ◽  
Jonathan T Avon ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Sensory Neurons ◽  
Sensory Input ◽  
Odorant Receptors ◽  
Projection Neurons ◽  
Olfactory Sensory Neurons ◽  
Odor Processing ◽  
Newborn Neurons ◽  
Behavioral Assays

Postnatal neurogenesis provides an opportunity to understand how newborn neurons functionally integrate into circuits to restore lost function. Newborn olfactory sensory neurons (OSNs) wire into highly organized olfactory bulb (OB) circuits throughout life, enabling lifelong plasticity and regeneration. Immature OSNs can form functional synapses capable of evoking firing in OB projection neurons. However, what contribution, if any, immature OSNs make to odor processing is unknown. Indeed, because immature OSNs can express multiple odorant receptors, any input that they do provide could degrade the odorant selectivity of input to OB glomeruli. Here, we used a combination of in vivo 2-photon calcium imaging, optogenetics, electrophysiology and behavioral assays to show that immature OSNs provide odor input to the OB, where they form monosynaptic connections with excitatory neurons. Importantly, immature OSNs responded as selectively to odorants as mature OSNs. Furthermore, mice successfully performed odor detection tasks using sensory input from immature OSNs alone. Immature OSNs responded more strongly to low odorant concentrations but their responses were less concentration dependent than those of mature OSNs, suggesting that immature and mature OSNs provide distinct odor input streams to each glomerulus. Together, our findings suggest that sensory input mediated by immature OSNs plays a previously unappreciated role in olfactory-guided behavior.

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