scholarly journals Prevalence of antibiotic resistance and virulence factors encoding genes in clinical Staphylococcus aureus isolates in Saudi Arabia

2017 ◽  
Vol 5 (4) ◽  
pp. 196-202 ◽  
Author(s):  
Hussein H. Abulreesh ◽  
Sameer R. Organji ◽  
Gamal E.H. Osman ◽  
Khaled Elbanna ◽  
Meshal H.K. Almalki ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Saudi Arabia ◽  
Antibiotic Resistance ◽  
Virulence Factors ◽  
Encoding Genes

A review of virulence factors, pathogenesis, and antibiotic resistance in Staphylococcus aureus

2016 ◽  
Vol 27 (2) ◽  
pp. 50-56 ◽  
Author(s):  
Nada Fahad Al-Mebairik ◽  
Talat A. El-Kersh ◽  
Yazeed A. Al-Sheikh ◽  
Mohammed Ali M. Marie
Keyword(s):  
Staphylococcus Aureus ◽  
Antibiotic Resistance ◽  
Virulence Factors

scholarly journals Going through phages: A Computational approach to Revealing the role of prophage in Staphylococcus aureus

2021 ◽  
Author(s):  
Tyrome Steven Sweet ◽  
Suzanne Sindi ◽  
Mark Sistrom
Keyword(s):  
Staphylococcus Aureus ◽  
Antibiotic Resistance ◽  
Genome Evolution ◽  
Virulence Factors ◽  
Rapid Growth ◽  
Computational Approach ◽  
Computational Pipeline ◽  
Genes Encoding

Prophages have important roles in virulence, antibiotic resistance and genome evolution in Staphylococcus aureus. Rapid growth in the number of sequenced S. aureus genomes allows for an investigation of prophage sequences in S. aureus at an unprecedented scale. We developed a computational pipeline to detect and analyze prophage sequences in nearly 10,011 S. aureus genomes, discovering thousands of putative prophage sequences with genes encoding virulence factors and antibiotic resistance.

scholarly journals 2602. Genetic Basis of Staphylococcus aureus Virulence

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S904-S904
Author(s):  
Edward W Adams ◽  
Doyle V Ward ◽  
Bruce A Barton ◽  
Richard T Ellison ◽  
Oladapo Olaitan
Keyword(s):  
Staphylococcus Aureus ◽  
Antibiotic Resistance ◽  
Virulence Factors ◽  
Resistance Genes ◽  
Gene Frequency ◽  
Academic Medical Center ◽  
Clinical Manifestations ◽  
Antibiotic Resistance Genes ◽  
Convenience Sample ◽  
Tract Infections

Abstract Background Although multiple different virulence factors have been identified for Staphylococcus aureus, there is limited information on genetic variation present between different strains of S. aureus in the clinical setting. To better define whether differing virulence factors could contribute to differing clinical manifestations of S. aureus infections we undertook a comparison of the frequency of virulence and antibiotic resistance genes present in S. aureus isolates from different clinical sites. Methods Whole-genome sequencing was performed on a convenience sample of S. aureus isolates from clinical or surveillance cultures obtained at an academic medical center over a 27-month period. Genomic assemblies were generated and annotated to define protein-coding regions. The prevalence of 28 genes previously defined as being associated with S. aureus virulence or antimicrobial resistance, including MSCRAMM genes, was then analyzed in relation to nine specific culture sources including only a single isolate from each culture source per patient using a likelihood ratio χ 2 analysis. Results There were 1286 S. aureus isolates with draft assemblies and annotations, and there was a statistically significant (P < 0.01) difference in gene frequencies between culture sources for 18 genes that included 13 of 19 virulence factors, 4 of 7 antibiotic resistance genes and 1 of 2 MSCRAMM genes. The most notable variation was seen for the presence of the sec, sep, entB, lukS, lufK, fosB, mecA, and ermA genes (all with P < 0.0001). There were also significant variations in overall gene frequency patterns between isolates from wound, blood, and respiratory isolates (P < 0.0001), as well as significant differences in the frequency of cna and hlY genes between surveillance and clinical isolates (P < 0.0001). Conclusion This study demonstrates a difference in the prevalence of virulence and antibiotic resistance genes in S. aureus isolates based on the culture source. As the culture location can be considered a surrogate for different types of infections (such as bacteremia, pneumonia, urinary tract infections) these differences in gene frequency may contribute to variation in the clinical manifestations of infections by differing S. aureus strains. Disclosures All authors: No reported disclosures.

A new anti-infective strategy to reduce the spreading of antibiotic resistance by the action on adhesion-mediated virulence factors in Staphylococcus aureus

2013 ◽  
Vol 63 ◽  
pp. 44-53 ◽  
Author(s):  
Rosanna Papa ◽  
Marco Artini ◽  
Andrea Cellini ◽  
Marco Tilotta ◽  
Eugenio Galano ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antibiotic Resistance ◽  
Virulence Factors
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