scholarly journals Total internal reflectance fluorescence imaging of genetically engineered ryanodine receptor-targeted Ca2+ probes in rat ventricular myocytes

Cell Calcium ◽  
2017 ◽  
Vol 66 ◽  
pp. 98-110 ◽  
Author(s):  
Sara Pahlavan ◽  
Marin Morad
Keyword(s):  
Fluorescence Imaging ◽  
Ryanodine Receptor ◽  
Ventricular Myocytes ◽  
Genetically Engineered ◽  
Rat Ventricular Myocytes ◽  
Total Internal Reflectance ◽  
Internal Reflectance

scholarly journals Analysis of Cav1.2 and Ryanodine Receptor Clusters in Rat Ventricular Myocytes

2010 ◽  
Vol 99 (12) ◽  
pp. 3923-3929 ◽  
Author(s):  
David R.L. Scriven ◽  
Parisa Asghari ◽  
Meredith N. Schulson ◽  
Edwin D.W. Moore
Keyword(s):  
Ryanodine Receptor ◽  
Ventricular Myocytes ◽  
Rat Ventricular Myocytes ◽  
Receptor Clusters

Effect of reduction in ryanodine receptor calcium leak on arrhythmogenesis in rat ventricular myocytes

The Lancet ◽  
2014 ◽  
Vol 383 ◽  
pp. S93
Author(s):  
Rajiv Sankaranarayanan ◽  
Yatong Li ◽  
Luigi Venetucci ◽  
David Eisner
Keyword(s):  
Ryanodine Receptor ◽  
Ventricular Myocytes ◽  
Rat Ventricular Myocytes

CARP Plays a Key Role in Cellular Growth Under Hypertrophic Stimuli in Neonatal Rat Ventricular Myocytes

2013 ◽  
Vol 9 ◽  
Author(s):  
Tara A Shrout
Keyword(s):  
Gene Expression ◽  
Ventricular Myocytes ◽  
Cellular Growth ◽  
Neonatal Rat ◽  
Transcriptional Level ◽  
Dual Nature ◽  
Hypertrophic Growth ◽  
Rat Ventricular Myocytes ◽  
Neonatal Rat Ventricular Myocytes ◽  
Over Time

Cardiac hypertrophy is a growth process that occurs in response to stress stimuli or injury, and leads to the induction of several pathways to alter gene expression. Under hypertrophic stimuli, sarcomeric structure is disrupted, both as a consequence of gene expression and local changes in sarcomeric proteins. Cardiac-restricted ankyrin repeat protein (CARP) is one such protein that function both in cardiac sarcomeres and at the transcriptional level. We postulate that due to this dual nature, CARP plays a key role in maintaining the cardiac sarcomere. GATA4 is another protein detected in cardiomyocytes as important in hypertrophy, as it is activated by hypertrophic stimuli, and directly binds to DNA to alter gene expression. Results of GATA4 activation over time were inconclusive; however, the role of CARP in mediating hypertrophic growth in cardiomyocytes was clearly demonstrated. In this study, Neonatal Rat Ventricular Myocytes were used as a model to detect changes over time in CARP and GATA4 under hypertrophic stimulation by phenylephrine and high serum media. Results were detected by analysis of immunoblotting. The specific role that CARP plays in mediating cellular growth under hypertrophic stimuli was studied through immunofluorescence, which demonstrated that cardiomyocyte growth with hypertrophic stimulation was significantly blunted when NRVMs were co-treated with CARP siRNA. These data suggest that CARP plays an important role in the hypertrophic response in cardiomyocytes.

Estimation of myofibrillar responsiveness to Ca 2+ in isolated rat ventricular myocytes

1998 ◽  
Vol 436 (5) ◽  
pp. 639-645 ◽  
Author(s):  
K. Hongo ◽  
Yoichiro Kusakari ◽  
Masato Konishi ◽  
Satoshi Kurihara ◽  
Seibu Mochizuki
Keyword(s):  
Ventricular Myocytes ◽  
Rat Ventricular Myocytes ◽  
Isolated Rat

Dofetilide Enhances the Contractility of Rat Ventricular Myocytes via Augmentation of Na+–Ca2+ Exchange

2009 ◽  
Vol 23 (3) ◽  
pp. 207-214 ◽  
Author(s):  
Xuan-Ping Zhang ◽  
Bo-Wei Wu ◽  
Cai-Hong Yang ◽  
Jie Wang ◽  
Shuan-Cheng Niu ◽  
...  
Keyword(s):  
Ventricular Myocytes ◽  
Rat Ventricular Myocytes
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