scholarly journals Use of a precious resource: Parental decision making about using autologous umbilical cord blood in studies involving young children with type 1 diabetes

2011 ◽  
Vol 32 (4) ◽  
pp. 524-529 ◽  
Author(s):  
Kimberly A. Driscoll ◽  
Suzanne Bennett Johnson ◽  
Desmond A. Schatz ◽  
Michael J. Haller
Keyword(s):  
Decision Making ◽  
Type 1 Diabetes ◽  
Young Children ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Parental Decision ◽  
Parental Decision Making ◽  
Precious Resource

scholarly journals Autologous Umbilical Cord Blood Transfusion in Young Children With Type 1 Diabetes Fails to Preserve C-Peptide

Diabetes Care ◽  
2011 ◽  
Vol 34 (12) ◽  
pp. 2567-2569 ◽  
Author(s):  
M. J. Haller ◽  
C. H. Wasserfall ◽  
M. A. Hulme ◽  
M. Cintron ◽  
T. M. Brusko ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Blood Transfusion ◽  
Young Children ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
C Peptide

scholarly journals Autologous Umbilical Cord Blood Transfusion in Very Young Children With Type 1 Diabetes

Diabetes Care ◽  
2009 ◽  
Vol 32 (11) ◽  
pp. 2041-2046 ◽  
Author(s):  
M. J. Haller ◽  
C. H. Wasserfall ◽  
K. M. McGrail ◽  
M. Cintron ◽  
T. M. Brusko ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Blood Transfusion ◽  
Young Children ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Very Young Children

scholarly journals Umbilical Cord Blood DNA Methylation in Children Who Later Develop Type 1 Diabetes

2021 ◽  
Author(s):  
Essi Laajala ◽  
Ubaid Ullah ◽  
Toni Grönroos ◽  
Omid Rasool ◽  
Viivi Halla-aho ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Type 1 Diabetes ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Reduced Representation ◽  
Prediction And Prevention ◽  
Develop Type ◽  
Methylation Patterns

Distinct DNA methylation patterns have recently been observed to precede type 1 diabetes in whole blood collected from young children. Our aim was to determine, whether perinatal DNA methylation could be associated with later progression to type 1 diabetes. Reduced representation bisulfite sequencing (RRBS) analysis was performed on umbilical cord blood samples collected within the Type 1 Diabetes Prediction and Prevention (DIPP) study. Children later diagnosed with type 1 diabetes and/or testing positive for multiple islet autoantibodies (N=43) were compared to control individuals (N=79), who remained autoantibody-negative throughout the DIPP follow-up until 15 years of age. Potential confounding factors related to the pregnancy and the mother were included in the analysis. No differences in the cord blood methylation patterns were observed between these cases and controls.

scholarly journals Autologous umbilical cord blood infusion for type 1 diabetes

2008 ◽  
Vol 36 (6) ◽  
pp. 710-715 ◽  
Author(s):  
Michael J. Haller ◽  
Hilla-Lee Viener ◽  
Clive Wasserfall ◽  
Todd Brusko ◽  
Mark A. Atkinson ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood

Parental Decision-Making for Surgery and Anesthesia in Young Children

2021 ◽  
pp. 019394592110216
Author(s):  
Audrey Rosenblatt ◽  
Michael Kremer ◽  
Olimpia Paun ◽  
Barbara Swanson ◽  
Rebekah Hamilton ◽  
...  
Keyword(s):  
Health Care ◽  
Decision Making ◽  
Young Children ◽  
Cognitive Processing ◽  
Emotional Processing ◽  
Theory Analysis ◽  
Parental Decision ◽  
Parental Decision Making ◽  
Health Care Context ◽  
The Relationship

Millions of young children undergo surgery and anesthesia each year, yet there is a lack of scientific consensus about the safety of anesthesia exposure for the developing brain. Also poorly understood is parental anesthesia-related decision-making and how neurotoxicity information influences their choices. The theoretical model of parental decision-making generated in this research explicates this process. Interviews with 24 mothers yielded a theoretical framework based on their narratives developed using a qualitative grounded theory analysis. Five major themes emerged from these interviews: emotional processing, cognitive processing, relationships as resources, the mother/child dyad, and the health care context. Mothers described a non-linear, iterative process; they moved fluidly through emotional and cognitive processing supported by relationships as resources and influenced by the health care context. A key element was the subtheme of the medical translator, an individual who provided context and information. The mother/child dyad grounded the model in the relationship with the child.

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