Significant association of past parvovirus B19 infection with cytopenia in both adult-onset Still's disease and systemic lupus erythematosus patients

2012 ◽  
Vol 413 (9-10) ◽  
pp. 855-860 ◽  
Author(s):  
Der-Yuan Chen ◽  
Yi-Ming Chen ◽  
Joung-Liang Lan ◽  
Bor-Show Tzang ◽  
Chi-Chen Lin ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Parvovirus B19 ◽  
Adult Onset Still’S Disease ◽  
Adult Onset ◽  
Still’S Disease ◽  
Systemic Lupus ◽  
Still's Disease ◽  
Parvovirus B19 Infection ◽  
Adult Onset Still's Disease

scholarly journals Systemic Lupus Erythematosus (SLE) in a male patient previously diagnosed as Adult Onset Still’s Disease: A Case Report

2019 ◽  
Vol 30 (2) ◽  
pp. 100-103
Author(s):  
Md Anwar Sayed ◽  
Suman Chowdhury
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Case Report ◽  
Male Patient ◽  
Lupus Erythematosus ◽  
Adult Onset Still’S Disease ◽  
Adult Onset ◽  
Still’S Disease ◽  
Systemic Lupus ◽  
Still's Disease ◽  
Adult Onset Still's Disease

Adult-onset Still’s disease (AOSD) is a rare clinical entity with unknown etiology, characterized by evanescent rash, arthritis, fever, and other systemic presentation. In this case report, we describe a male patient of 50 years, previously diagnosed as a case of Adult onset still’s disease based on Yamaguchi criteria after the exclusion of other potential diagnoses. Later he was admitted into the Medicine department of Chittagong Medical College Hospital where he was found to have serological features of Systemic lupus erythematosus, another very much uncommon autoimmune disorder in male. On several occasion of his past admissions, SLE and RA were excluded meticulously. He initially responded to oral steroids only, recurrence of symptoms led us to work on the underlying etiology further. Coexistence of SLE in a patient with AOSD is not so commonly found. In our case, we notice this interesting phenomenon which was crucial for his management. Bangladesh J Medicine July 2019; 30(2) : 100-103

scholarly journals Adult-Onset Still’s Disease Associated with Thyroid Dysfunction: Case Report and Review of the Literature

2014 ◽  
Vol 8 (1) ◽  
pp. 9-12 ◽  
Author(s):  
Yingchun Hu ◽  
Han Wang ◽  
Juelin Deng
Keyword(s):  
Autoimmune Disease ◽  
Lupus Erythematosus ◽  
Adult Onset Still’S Disease ◽  
Systemic Autoimmune Disease ◽  
Adult Onset ◽  
Still’S Disease ◽  
Autoimmune Thyroid ◽  
The Past ◽  
Still's Disease ◽  
Adult Onset Still's Disease

To our knowledge, the possible unveiled interaction between adult-onset Still’s disease (AOSD) with autoimmune thyroid disease (AITD) has never been reported although it is well established that systemic autoimmune disease may usually occur in relation to AITD. As increasingly clear links of AITD with other autoimmune disease such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and primary Sjögren’s syndrome (pSS) have been reported, and the incidence of AOSD concurrent AITD draws our attention rapidly. In this study, we searched relevant literatures published in the past 30 years to explore that condition.

scholarly journals IL-18 Serum Level in Adult Onset Still’s Disease: A Marker of Disease Activity

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Serena Colafrancesco ◽  
Roberta Priori ◽  
Cristiano Alessandri ◽  
Carlo Perricone ◽  
Monica Pendolino ◽  
...  
Keyword(s):  
Disease Activity ◽  
Lupus Erythematosus ◽  
Therapeutic Option ◽  
Serum Levels ◽  
Adult Onset Still’S Disease ◽  
Adult Onset ◽  
Still’S Disease ◽  
Still's Disease ◽  
Human Sera ◽  
Adult Onset Still's Disease

Introduction. Immunological factors seem to play a pivotal role in Adult Onset Still's Disease (AOSD). Among all, IL-18 cytokine is overexpressed and drives the inflammatory process.Objective. We aimed to investigate the levels of IL-18 in sera of Italian patients with AOSD and to assess its possible role as a marker of disease activity.Methods. IL-18 serum levels were determined by ELISA in 26 Italian patients with AOSD. Disease activity was assessed using Pouchot’s criteria. As controls, 21 patients with Rheumatoid Arthritis (RA), 21 patients with Sjogren's Syndrome (SS), 20 patients with Systemic Lupus Erythematosus (SLE), and 21 healthy subjects (normal human sera, NHS) were evaluated.Results. IL-18 serum levels were significantly higher in patients with active AOSD than in non-active (P=0.001) and control groups (RAP=0.0070, SSP=0.0029, SLEP=0.0032, NHSP=0.0004). A significant correlation between IL-18 serum levels and disease activity (P<0.0001), and laboratory parameters as ferritin (P=0.0127) and C-reactive protein (P=0.0032) was demonstrated.Conclusions. Higher levels of IL-18 are detected in active AODS patients and correlate with disease activity and inflammatory laboratory features. ROC-AUC analysis of the serum concentration of IL-18 suggests that it can be considered a diagnostic marker of AOSD. This paper supports the targeting of this cytokine as a possible therapeutic option in AOSD.

scholarly journals Adult-onset Still's Disease: A Case Report

2020 ◽  
Vol 58 (222) ◽  
Author(s):  
Ashok Sapkota ◽  
Nirdesh Pokhrel ◽  
Jayaram Adhikari ◽  
Bishal Shrestha ◽  
Yoveen Kumar Yadav
Keyword(s):  
Parvovirus B19 ◽  
Ferritin Level ◽  
Adult Onset Still’S Disease ◽  
Unknown Etiology ◽  
Inflammatory Disorder ◽  
Adult Onset ◽  
Still’S Disease ◽  
Past Infection ◽  
Still's Disease ◽  
Adult Onset Still's Disease

Adult-onset Still’s Disease is a rare auto inflammatory disorder of unknown etiology characterized mainly by high spiking fever, arthritis, evanescent rash and lymphadenopathy. It is a form of systemic onset juvenile rheumatoid arthritis that is encountered in adults, typically between 15-25 years and 36-45years. We here describe a 28 years lady with fever, arthritis of multiple large joints, lymphadenopathy and rash, with negative Rheumatoid factor and evidence of past infection with Ebstein-Barr virus and Parvovirus B19. History, examination findings and investigations showed several features consistent with adult-onset Still’s disease along with high ferritin level. After exclusion of probable other diagnosis and use of Yamaguchi criteria, she was diagnosed with adult-onset Still’s disease. All the major and minor criteria of Yamaguchi for diagnosis were met. Her disease responded well with steroid, she achieved remission and is currently under maintenance therapy.

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