Triphenyltin exposure alters the antioxidant system, energy metabolism and the expression of genes related to physiological stress in zebrafish (Danio rerio)

Author(s):  
Ping Li ◽  
Zhi-Hua Li ◽  
Liqiao Zhong
2021 ◽  
pp. 482-490
Author(s):  
Neşe AKPINAR KOCAKULAK ◽  
Serpil TAHERİ ◽  
Elif Funda ŞENER ◽  
Kenan AYCAN ◽  
Yusuf ÖZKUL

Author(s):  
Ottassano S. Panetto ◽  
Helga F. Gomes ◽  
Danielle S. Fraga Gomes ◽  
Eldo Campos ◽  
Nelilma C. Romeiro ◽  
...  

Author(s):  
Ramesh Gogulothu ◽  
Devika Nagar ◽  
Srividya Gopalakrishnan ◽  
Venkat R. Garlapati ◽  
Prathap R. Kallamadi ◽  
...  

2019 ◽  
Vol 41 ◽  
pp. e42709
Author(s):  
Gabriele Casarotto ◽  
Tiago Edu Kaspary ◽  
Luan Cutti ◽  
André Luis Thomas ◽  
Jose Fernandes Barbosa Neto

The flooded environment brings about injuries to soybeans that vary depending on the adaptation ability of the genotype. Oxygen deprivation promotes the induction of the expression of genes related to glycolysis and fermentation pathways to maintain energy metabolism and, in addition to reducing-power consuming processes, act in the formation of adaptive structures and the maintenance of the redox status of the plant. The aim of this work was to evaluate the relative expression of genes related to soil flooding response in two contrasting soybean cultivars. Soybean plants of the sensitive (BRS 154) and tolerant (I27) cultivars at the V1 development stage were submitted to the flooding and control conditions (without flooding) for 0, 24, 48, and 96 hours. The relative expression of genes associated with flooding, including enolase (ENO), alcohol dehydrogenase 1 (ADH1), alanine aminotransferase 2 (ALAT2), hemoglobin 1 (GLB1), LOB41 domain-containing protein (LBD41), xyloglucan endotransglycosylase (XETP) and ascorbate peroxidase (APX2), was evaluated by means of RT-qPCR. The relative expression, in general, increased with flooding, especially in the root tissue. Cultivar I27 responded positively as observed by the expression of the maintenance genes of energy metabolism, structural changes and detoxification, suggesting the presence of three tolerance mechanisms in the flooding response.


PPAR Research ◽  
2008 ◽  
Vol 2008 ◽  
pp. 1-10 ◽  
Author(s):  
Jennifer G. Duncan ◽  
Brian N. Finck

The mammalian myocardium is an omnivorous organ that relies on multiple substrates in order to fulfill its tremendous energy demands. Cardiac energy metabolism preference is regulated at several critical points, including at the level of gene transcription. Emerging evidence indicates that the nuclear receptor PPARαand its cardiac-enriched coactivator protein, PGC-1α, play important roles in the transcriptional control of myocardial energy metabolism. The PPARα-PGC-1αcomplex controls the expression of genes encoding enzymes involved in cardiac fatty acid and glucose metabolism as well as mitochondrial biogenesis. Also, evidence has emerged that the activity of the PPARα-PGC-1αcomplex is perturbed in several pathophysiologic conditions and that altered activity of this pathway may play a role in cardiomyopathic remodeling. In this review, we detail the current understanding of the effects of the PPARα-PGC-1αaxis in regulating mitochondrial energy metabolism and cardiac function in response to physiologic and pathophysiologic stimuli.


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