Insights on the age dependent neurodegeneration induced by Monocrotophos, (an organophosphorous insecticide) in Caenorhabditis elegans fed high glucose : Evidence in wild and transgenic strains

2018 ◽  
Vol 211 ◽  
pp. 15-24 ◽  
Author(s):  
Chinnu Salim ◽  
Nidheesh Thadathil ◽  
M. Muralidhara ◽  
P.S. Rajini
Keyword(s):  
Caenorhabditis Elegans ◽  
High Glucose ◽  
Organophosphorous Insecticide ◽  
Age Dependent ◽  
Transgenic Strains

scholarly journals TDP-1/TDP-43 Regulates Stress Signaling and Age-Dependent Proteotoxicity in Caenorhabditis elegans

PLoS Genetics ◽  
2012 ◽  
Vol 8 (7) ◽  
pp. e1002806 ◽  
Author(s):  
Alexandra Vaccaro ◽  
Arnaud Tauffenberger ◽  
Peter E. A. Ash ◽  
Yari Carlomagno ◽  
Leonard Petrucelli ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Stress Signaling ◽  
Age Dependent

Loss of miR-83 extends lifespan and affects target gene expression in an age-dependent manner in Caenorhabditis elegans

2018 ◽  
Vol 45 (12) ◽  
pp. 651-662 ◽  
Author(s):  
Emmanuel Enoch Dzakah ◽  
Ahmed Waqas ◽  
Shuai Wei ◽  
Bin Yu ◽  
Xiaolin Wang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Caenorhabditis Elegans ◽  
Target Gene ◽  
Dependent Manner ◽  
Target Gene Expression ◽  
Age Dependent

scholarly journals High-glucose diets induce mitochondrial dysfunction in Caenorhabditis elegans

PLoS ONE ◽  
2019 ◽  
Vol 14 (12) ◽  
pp. e0226652 ◽  
Author(s):  
Jonathan Alcántar-Fernández ◽  
Angélica González-Maciel ◽  
Rafael Reynoso-Robles ◽  
Martha Elva Pérez Andrade ◽  
Alain de J. Hernández-Vázquez ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Mitochondrial Dysfunction ◽  
High Glucose

Bisphenol S increases the obesogenic effects of a high-glucose diet through regulating lipid metabolism in Caenorhabditis elegans

2021 ◽  
Vol 339 ◽  
pp. 127813
Author(s):  
Xiang Xiao ◽  
Xiaowei Zhang ◽  
Juan Bai ◽  
Jie Li ◽  
Caiqin Zhang ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Caenorhabditis Elegans ◽  
High Glucose ◽  
Bisphenol S

scholarly journals DAF-16 and SMK-1 Contribute to Innate Immunity During Adulthood in Caenorhabditis elegans

2020 ◽  
Vol 10 (5) ◽  
pp. 1521-1539 ◽  
Author(s):  
Daniel R. McHugh ◽  
Elena Koumis ◽  
Paul Jacob ◽  
Jennifer Goldfarb ◽  
Michelle Schlaubitz-Garcia ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Immune System ◽  
Caenorhabditis Elegans ◽  
Host Defense ◽  
Insulin Signaling ◽  
Bacterial Pathogens ◽  
C Elegans ◽  
Link Type ◽  
Age Dependent ◽  
Over Time

Aging is accompanied by a progressive decline in immune function termed “immunosenescence”. Deficient surveillance coupled with the impaired function of immune cells compromises host defense in older animals. The dynamic activity of regulatory modules that control immunity appears to underlie age-dependent modifications to the immune system. In the roundworm Caenorhabditis elegans levels of PMK-1 p38 MAP kinase diminish over time, reducing the expression of immune effectors that clear bacterial pathogens. Along with the PMK-1 pathway, innate immunity in C. elegans is regulated by the insulin signaling pathway. Here we asked whether DAF-16, a Forkhead box (FOXO) transcription factor whose activity is inhibited by insulin signaling, plays a role in host defense later in life. While in younger C. elegansDAF-16 is inactive unless stimulated by environmental insults, we found that even in the absence of acute stress the transcriptional activity of DAF-16 increases in an age-dependent manner. Beginning in the reproductive phase of adulthood, DAF-16 upregulates a subset of its transcriptional targets, including genes required to kill ingested microbes. Accordingly, DAF-16 has little to no role in larval immunity, but functions specifically during adulthood to confer resistance to bacterial pathogens. We found that DAF-16-mediated immunity in adults requires SMK-1, a regulatory subunit of the PP4 protein phosphatase complex. Our data suggest that as the function of one branch of the innate immune system of C. elegans (PMK-1) declines over time, DAF-16-mediated immunity ramps up to become the predominant means of protecting adults from infection, thus reconfiguring immunity later in life.

Reserpine modulates neurotransmitter release to extend lifespan and alleviate age-dependent Aβ proteotoxicity in Caenorhabditis elegans

2012 ◽  
Vol 47 (2) ◽  
pp. 188-197 ◽  
Author(s):  
Kopal Saharia ◽  
Upasna Arya ◽  
Ranjeet Kumar ◽  
Rashmi Sahu ◽  
Chinmaya Kumar Das ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Neurotransmitter Release ◽  
Age Dependent

daf-16/FOXO and glod-4/glyoxalase-1 are required for the life-prolonging effect of human insulin under high glucose conditions in Caenorhabditis elegans

Diabetologia ◽  
2014 ◽  
Vol 58 (2) ◽  
pp. 393-401 ◽  
Author(s):  
Michael Mendler ◽  
Andreas Schlotterer ◽  
Youssef Ibrahim ◽  
Georgi Kukudov ◽  
Thomas Fleming ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Human Insulin ◽  
High Glucose ◽  
Glyoxalase 1
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