Beneficial effects of natural antioxidants EGCG and α-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans

2006 ◽  
Vol 85 (3) ◽  
pp. 620-628 ◽  
Author(s):  
M BROWN ◽  
J EVANS ◽  
Y LUO
Keyword(s):  
Caenorhabditis Elegans ◽  
Life Span ◽  
Lipoic Acid ◽  
Natural Antioxidants ◽  
Beneficial Effects ◽  
Age Dependent

scholarly journals Caenorhabditis elegans Genes Affecting Interindividual Variation in Life-span Biomarker Gene Expression

2017 ◽  
Vol 72 (10) ◽  
pp. 1305-1310 ◽  
Author(s):  
Alexander Mendenhall ◽  
Matthew M Crane ◽  
Patricia M Tedesco ◽  
Thomas E Johnson ◽  
Roger Brent
Keyword(s):  
Gene Expression ◽  
Caenorhabditis Elegans ◽  
Life Span ◽  
Interindividual Variation

scholarly journals Genetic, Behavioral and Environmental Determinants of Male Longevity in Caenorhabditis elegans

Genetics ◽  
2000 ◽  
Vol 154 (4) ◽  
pp. 1597-1610 ◽  
Author(s):  
David Gems ◽  
Donald L Riddle
Keyword(s):  
Caenorhabditis Elegans ◽  
Life Span ◽  
Wild Type ◽  
Neuronal Function ◽  
Nematode Caenorhabditis Elegans ◽  
Wild Isolate ◽  
Young Males ◽  
C Elegans ◽  
Single Sex ◽  
Solitary Males

Abstract Males of the nematode Caenorhabditis elegans are shorter lived than hermaphrodites when maintained in single-sex groups. We observed that groups of young males form clumps and that solitary males live longer, indicating that male-male interactions reduce life span. By contrast, grouped or isolated hermaphrodites exhibited the same longevity. In one wild isolate of C. elegans, AB2, there was evidence of copulation between males. Nine uncoordinated (unc) mutations were used to block clumping behavior. These mutations had little effect on hermaphrodite life span in most cases, yet many increased male longevity even beyond that of solitary wild-type males. In one case, the neuronal function mutant unc-64(e246), hermaphrodite life span was also increased by up to 60%. The longevity of unc-4(e120), unc-13(e51), and unc-32(e189) males exceeded that of hermaphrodites by 70–120%. This difference appears to reflect a difference in sex-specific life span potential revealed in the absence of male behavior that is detrimental to survival. The greater longevity of males appears not to be affected by daf-2, but is influenced by daf-16. In the absence of male-male interactions, median (but not maximum) male life span was variable. This variability was reduced when dead bacteria were used as food. Maintenance on dead bacteria extended both male and hermaphrodite longevity.

scholarly journals TDP-1/TDP-43 Regulates Stress Signaling and Age-Dependent Proteotoxicity in Caenorhabditis elegans

PLoS Genetics ◽  
2012 ◽  
Vol 8 (7) ◽  
pp. e1002806 ◽  
Author(s):  
Alexandra Vaccaro ◽  
Arnaud Tauffenberger ◽  
Peter E. A. Ash ◽  
Yari Carlomagno ◽  
Leonard Petrucelli ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Stress Signaling ◽  
Age Dependent

Loss of miR-83 extends lifespan and affects target gene expression in an age-dependent manner in Caenorhabditis elegans

2018 ◽  
Vol 45 (12) ◽  
pp. 651-662 ◽  
Author(s):  
Emmanuel Enoch Dzakah ◽  
Ahmed Waqas ◽  
Shuai Wei ◽  
Bin Yu ◽  
Xiaolin Wang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Caenorhabditis Elegans ◽  
Target Gene ◽  
Dependent Manner ◽  
Target Gene Expression ◽  
Age Dependent

scholarly journals 14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans

2008 ◽  
Vol 43 (6) ◽  
pp. 505-519 ◽  
Author(s):  
Caroline Araiz ◽  
Marie-Thérèse Château ◽  
Simon Galas
Keyword(s):  
Caenorhabditis Elegans ◽  
Life Span

scholarly journals Absence of strong heterosis for life span and other life history traits in Caenorhabditis elegans.

Genetics ◽  
1993 ◽  
Vol 134 (2) ◽  
pp. 465-474 ◽  
Author(s):  
T E Johnson ◽  
E W Hutchinson
Keyword(s):  
Life History ◽  
Caenorhabditis Elegans ◽  
Life Span ◽  
Life History Traits ◽  
Environmental Variation ◽  
F1 Hybrids ◽  
Wild Type ◽  
Wild Strains ◽  
And Behavior ◽  
Type Strains

Abstract We have examined crosses between wild-type strains of Caenorhabditis elegans for heterosis effects on life span and other life history traits. Hermaphrodites of all wild strains had similar life expectancies but males of two strains had shorter life spans than hermaphrodites while males of two other strains lived longer than hermaphrodites. F1 hermaphrodite progeny showed no heterosis while some heterosis for longer life span was detected in F1 males. F1 hybrids of crosses between two widely studied wild-type strains, N2 (var. Bristol) and Berg BO (var. Bergerac), were examined for rate of development, hermaphrodite fertility, and behavior; there was no heterosis for these life history traits. Both controlled variation of temperature and uncontrolled environmental variation affected the length of life of all genotypes. Significant G x E effects on life span were observed in comparisons of N2 and Berg BO hermaphrodites, or N2 hermaphrodites and males, or N2 and a Ts mutant strain (DH26). Nevertheless, within an experiment, environmental variation was minimal and life spans were quite replicable.

scholarly journals Temporal Transcriptomics of Gut Escherichia coli in Caenorhabditis elegans Models of Aging

2021 ◽  
Author(s):  
Joshua D. Brycki ◽  
Jeremy R. Chen See ◽  
Gillian R. Letson ◽  
Cade S. Emlet ◽  
Lavinia V. Unverdorben ◽  
...  
Keyword(s):  
Gene Expression ◽  
Escherichia Coli ◽  
Caenorhabditis Elegans ◽  
Life Span ◽  
Wild Type ◽  
Health Span ◽  
Content Type ◽  
C Elegans ◽  
Evolutionarily Conserved

Previous research has reported effects of the microbiome on health span and life span of Caenorhabditis elegans , including interactions with evolutionarily conserved pathways in humans. We build on this literature by reporting the gene expression of Escherichia coli OP50 in wild-type (N2) and three long-lived mutants of C. elegans .

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