Effect of copper exposure on GST activity and on the expression of four GSTs under oxidative stress condition in the monogonont rotifer, Brachionus koreanus

2013 ◽  
Vol 158 (2) ◽  
pp. 91-100 ◽  
Author(s):  
Jeonghoon Han ◽  
Eun-Ji Won ◽  
Dae-Sik Hwang ◽  
Jae-Sung Rhee ◽  
Il-Chan Kim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stress Condition ◽  
Copper Exposure ◽  
Oxidative Stress Condition ◽  
Brachionus Koreanus ◽  
Monogonont Rotifer ◽  
Effect Of Copper ◽  
Gst Activity

scholarly journals Effects of CaMKII Regulation on Atrial Action Potential Under Oxidative Stress Condition

2018 ◽  
Author(s):  
Haibo Sui ◽  
Qince Li ◽  
Kuanquan Wang ◽  
Funebi Francis Ijebu ◽  
Yongfeng Yuan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Action Potential ◽  
Stress Condition ◽  
Oxidative Stress Condition

scholarly journals L-Carnitine: An Antioxidant Remedy for the Survival of Cardiomyocytes under Hyperglycemic Condition

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Fernanda Vacante ◽  
Pamela Senesi ◽  
Anna Montesano ◽  
Alice Frigerio ◽  
Livio Luzi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Dysfunction ◽  
Signaling Pathways ◽  
Stress Condition ◽  
Cardiac Cells ◽  
Ros Production ◽  
Protective Effects ◽  
H9c2 Cells ◽  
Rat Cardiomyocytes ◽  
Oxidative Stress Condition

Background. Metabolic alterations as hyperglycemia and inflammation induce myocardial molecular events enhancing oxidative stress and mitochondrial dysfunction. Those alterations are responsible for a progressive loss of cardiomyocytes, cardiac stem cells, and consequent cardiovascular complications. Currently, there are no effective pharmacological measures to protect the heart from these metabolic modifications, and the development of new therapeutic approaches, focused on improvement of the oxidative stress condition, is pivotal. The protective effects of levocarnitine (LC) in patients with ischemic heart disease are related to the attenuation of oxidative stress, but LC mechanisms have yet to be fully understood. Objective. The aim of this work was to investigate LC’s role in oxidative stress condition, on ROS production and mitochondrial detoxifying function in H9c2 rat cardiomyocytes during hyperglycemia. Methods. H9c2 cells in the hyperglycemic state (25 mmol/L glucose) were exposed to 0.5 or 5 mM LC for 48 and 72 h: LC effects on signaling pathways involved in oxidative stress condition were studied by Western blot and immunofluorescence analysis. To evaluate ROS production, H9c2 cells were exposed to H2O2 after LC pretreatment. Results. Our in vitro study indicates how LC supplementation might protect cardiomyocytes from oxidative stress-related damage, preventing ROS formation and activating antioxidant signaling pathways in hyperglycemic conditions. In particular, LC promotes STAT3 activation and significantly increases the expression of antioxidant protein SOD2. Hyperglycemic cardiac cells are characterized by impairment in mitochondrial dysfunction and the CaMKII signal: LC promotes CaMKII expression and activation and enhancement of AMPK protein synthesis. Our results suggest that LC might ameliorate metabolic aspects of hyperglycemic cardiac cells. Finally, LC doses herein used did not modify H9c2 growth rate and viability. Conclusions. Our novel study demonstrates that LC improves the microenvironment damaged by oxidative stress (induced by hyperglycemia), thus proposing this nutraceutical compound as an adjuvant in diabetic cardiac regenerative medicine.

Microplastic Size-Dependent Toxicity, Oxidative Stress Induction, and p-JNK and p-p38 Activation in the Monogonont Rotifer (Brachionus koreanus)

2016 ◽  
Vol 50 (16) ◽  
pp. 8849-8857 ◽  
Author(s):  
Chang-Bum Jeong ◽  
Eun-Ji Won ◽  
Hye-Min Kang ◽  
Min-Chul Lee ◽  
Dae-Sik Hwang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stress Induction ◽  
Size Dependent ◽  
Brachionus Koreanus ◽  
Monogonont Rotifer

The SOD-2 protein is the single active SOD enzyme in C. elegans

2020 ◽  
Author(s):  
Lourds M. Fernando ◽  
Silwat Adeel ◽  
Mohammed Abul Basar ◽  
Anna K. Allen ◽  
Atanu Duttaroy
Keyword(s):  
Oxidative Stress ◽  
Stress Condition ◽  
Activity Analysis ◽  
Sod Activity ◽  
Mutant Analysis ◽  
Oxidative Stress Condition ◽  
E Coli ◽  
C Elegans ◽  
Aerobic Organism

ABSTRACTThe nematode C. elegans has a contingent of five sod genes, one of the largest among aerobic organism. Earlier studies revealed each of the five sod genes is capable of making perfectly active SOD proteins in heterologous expressions systems therefore none appears to be a pseudogene. Yet deletion of the entire contingent of sod genes fails to impose any effect on the survival of C. elegans except these animals appear more sensitive to extraneously applied oxidative stress condition. We asked how many of the five sod genes are actually active in C. elegans through an in-gel SOD activity analysis. Here we provide evidence that out of the five genes only the mitochondrial SOD gene is active in C. elegans, albeit at a much lesser amount compared to D. melanogaster and E. coli. Mutant analysis further confirmed that among the mitochondrial forms, SOD-2 is the only naturally active SOD in C. elegans.

scholarly journals Tissue Mechanisms of Adult Zebrafish Ventricular ECG Patterns under Baseline and Oxidative Stress Condition

2020 ◽  
Vol 118 (3) ◽  
pp. 259a
Author(s):  
Yali Zhao ◽  
Nicholas James ◽  
Ashraf Beshay ◽  
Eileen Chang ◽  
Thao P. Nguyen
Keyword(s):  
Oxidative Stress ◽  
Stress Condition ◽  
Adult Zebrafish ◽  
Oxidative Stress Condition ◽  
And Oxidative Stress
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