scholarly journals Bothrops moojeni myotoxin-II, a Lys49-phospholipase A2 homologue: An example of function versatility of snake venom proteins

2006 ◽  
Vol 142 (3-4) ◽  
pp. 371-381 ◽  
Author(s):  
Rodrigo G. Stábeli ◽  
Saulo F. Amui ◽  
Carolina D. Sant'Ana ◽  
Matheus G. Pires ◽  
Auro Nomizo ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Snake Venom ◽  
Bothrops Moojeni ◽  
Venom Proteins

scholarly journals Systemic alterations induced by phospholipase A2 , BmooTX-I, isolated from Bothrops moojeni snake venom

2018 ◽  
Vol 99 (5) ◽  
pp. 226-235 ◽  
Author(s):  
Kellen Cristina Torres Costa ◽  
Bruna Barbosa de Sousa ◽  
Edigar Henrique Vaz Dias ◽  
Déborah Fernanda da Cunha Pereira ◽  
Mariana Santos Matias ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Snake Venom ◽  
Bothrops Moojeni

Characterization of inflamin, the first member of a new family of snake venom proteins that induces inflammation

2013 ◽  
Vol 455 (2) ◽  
pp. 239-250 ◽  
Author(s):  
Bhaskar Barnwal ◽  
R. Manjunatha Kini
Keyword(s):  
Phospholipase A2 ◽  
Snake Venom ◽  
Calcium Dependent ◽  
Venom Toxin ◽  
New Family ◽  
Snake Venom Toxin ◽  
Venom Proteins

Inflamin, a novel snake venom toxin from Aipysurus eydouxii, leads to the activation of calcium-dependent phospholipase A2 by phosphorylation at Ser505, resulting in inflammation and pain.

Structural and Functional Characterization of Myotoxin I, a Lys49 Phospholipase A2 Homologue from Bothrops moojeni (Caissaca) Snake Venom

2000 ◽  
Vol 373 (1) ◽  
pp. 7-15 ◽  
Author(s):  
Andreimar M Soares ◽  
Sı́lvia H Andrião-Escarso ◽  
Yamileth Angulo ◽  
Bruno Lomonte ◽  
José M Gutiérrez ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Snake Venom ◽  
Functional Characterization ◽  
Bothrops Moojeni

scholarly journals In vitro Kinetics Study of Cerastes Cerastes Phospholipase A2 using Olive Leaf Extract: A Fluorescence Approach

2018 ◽  
Vol 3 (2) ◽  
Keyword(s):  
Phospholipase A2 ◽  
Snake Venom ◽  
Risk Evaluation ◽  
Therapeutic Drug ◽  
Additional Information ◽  
Zero Order Kinetics ◽  
Evaluation Strategies ◽  
In Vitro Kinetics ◽  
Venom Proteins

Understanding snake venom kinetics is crucial for developing risk evaluation strategies and determining the best dose and timing of antivenom required to bind all venom in snakebite patients. Polyphenolic compounds have shown to inhibit toxic effects induced by snake venom proteins. The interaction of polyphenols with Phospholipase A2 of Cerastes cerastes snake venom was investigated by fluorescence spectroscopy. The decrease in the fluorescence versus time was conducted at room temperature in 0.01 M Tris, 0.1 M NaCl at pH 7.4. The decrease in fluorescence was following a pattern of zero-order kinetics rate in which the fluorescence is decreasing linearly with time. This study is expected to offer additional information about the interactions of PLA2 with natural product that might lead to therapeutic drug.

A new acidic myotoxic, anti-platelet and prostaglandin I2 inductor phospholipase A2 isolated from Bothrops moojeni snake venom

Toxicon ◽  
2008 ◽  
Vol 52 (8) ◽  
pp. 908-917 ◽  
Author(s):  
Norival A. Santos-Filho ◽  
Lucas B. Silveira ◽  
Clayton Z. Oliveira ◽  
Carolina P. Bernardes ◽  
Danilo L. Menaldo ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Snake Venom ◽  
Prostaglandin I2 ◽  
Bothrops Moojeni

scholarly journals Cytotoxic and pro-apoptotic action of MjTX-I, a phospholipase A2 isolated from Bothrops moojeni snake venom, towards leukemic cells

2018 ◽  
Vol 24 (1) ◽  
Author(s):  
Rogério Bodini Benati ◽  
Tássia Rafaela Costa ◽  
Maira da Costa Cacemiro ◽  
Suely Vilela Sampaio ◽  
Fabíola Attié de Castro ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Snake Venom ◽  
Leukemic Cells ◽  
Bothrops Moojeni

scholarly journals A Neurotoxic Snake Venom without Phospholipase A2: Proteomics and Cross-Neutralization of the Venom from Senegalese Cobra, Naja senegalensis (Subgenus: Uraeus)

Toxins ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 60
Author(s):  
Kin Ying Wong ◽  
Kae Yi Tan ◽  
Nget Hong Tan ◽  
Choo Hock Tan
Keyword(s):  
Phospholipase A2 ◽  
Snake Venom ◽  
Lethal Effect ◽  
High Abundance ◽  
Western Africa ◽  
Venom Composition ◽  
Proteomic Approach ◽  
Cross Neutralization ◽  
Naja Haje ◽  
Venom Proteins

The Senegalese cobra, Naja senegalensis, is a non-spitting cobra species newly erected from the Naja haje complex. Naja senegalensis causes neurotoxic envenomation in Western Africa but its venom properties remain underexplored. Applying a protein decomplexation proteomic approach, this study unveiled the unique complexity of the venom composition. Three-finger toxins constituted the major component, accounting for 75.91% of total venom proteins. Of these, cardiotoxin/cytotoxin (~53%) and alpha-neurotoxins (~23%) predominated in the venom proteome. Phospholipase A2, however, was not present in the venom, suggesting a unique snake venom phenotype found in this species. The venom, despite the absence of PLA2, is highly lethal with an intravenous LD50 of 0.39 µg/g in mice, consistent with the high abundance of alpha-neurotoxins (predominating long neurotoxins) in the venom. The hetero-specific VINS African Polyvalent Antivenom (VAPAV) was immunoreactive to the venom, implying conserved protein antigenicity in the venoms of N. senegalensis and N. haje. Furthermore, VAPAV was able to cross-neutralize the lethal effect of N. senegalensis venom but the potency was limited (0.59 mg venom completely neutralized per mL antivenom, or ~82 LD50 per ml of antivenom). The efficacy of antivenom should be further improved to optimize the treatment of cobra bite envenomation in Africa.

Isolation and expression of a hypotensive and anti-platelet acidic phospholipase A2 from Bothrops moojeni snake venom

2013 ◽  
Vol 73 ◽  
pp. 35-43 ◽  
Author(s):  
Lucas B. Silveira ◽  
Daniela P. Marchi-Salvador ◽  
Norival A. Santos-Filho ◽  
Floriano P. Silva ◽  
Silvana Marcussi ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Snake Venom ◽  
Bothrops Moojeni

Biological and biochemical characterization of new basic phospholipase A2 BmTX-I isolated from Bothrops moojeni snake venom

Toxicon ◽  
2008 ◽  
Vol 51 (8) ◽  
pp. 1509-1519 ◽  
Author(s):  
Andrana K. Calgarotto ◽  
Daniela C.S. Damico ◽  
L.A. Ponce-Soto ◽  
Paulo A. Baldasso ◽  
Saulo L. Da Silva ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Snake Venom ◽  
Biochemical Characterization ◽  
Bothrops Moojeni
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