Knoevenagel condensation of aromatic aldehydes with active methylene compounds catalyzed by lipoprotein lipase

2015 ◽  
Vol 64 ◽  
pp. 101-104 ◽  
Author(s):  
Yan Ding ◽  
Xiao Ni ◽  
Mengjie Gu ◽  
Shuang Li ◽  
He Huang ◽  
...  
Keyword(s):  
Lipoprotein Lipase ◽  
Knoevenagel Condensation ◽  
Aromatic Aldehydes ◽  
Active Methylene Compounds ◽  
Active Methylene

A solvent free approach for Knoevenagel condensation: facile synthesis of 3-cyano and 3-carbethoxycoumarins

2014 ◽  
Vol 3 (3) ◽  
Author(s):  
Suresh Kumar
Keyword(s):  
Knoevenagel Condensation ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Efficient Synthesis ◽  
Facile Synthesis ◽  
Basic Alumina ◽  
Active Methylene Compounds ◽  
Active Methylene

AbstractA simple, efficient and solvent free approach for the Knoevenagel condensation has been developed which involves grinding of active methylene compounds with aromatic aldehydes over basic alumina. Using this solvent free Knoevenagel approach, a facile and efficient synthesis of 3-cyano and 3-carbethoxycoumarins has also been developed, which involves the grinding of 2-hydroxybenzaldehydes with malononitrile or ethylcyanoacetate respectively over basic alumina followed by grinding with p-toluenesulphonic acid (PTSA) in the same mortar.

Ethylene Glycol: Urea: NH 4 Cl Low Melting Mixture‐Assisted Reactions between Aromatic Aldehydes and Active Methylene Compounds

2021 ◽  
Vol 6 (28) ◽  
pp. 7150-7157
Author(s):  
Letcy V. Theresa ◽  
Saranya Ponmalakunnu ◽  
Anju M. Baby ◽  
Krishnapillai Sreekumar
Keyword(s):  
Ethylene Glycol ◽  
Aromatic Aldehydes ◽  
Active Methylene Compounds ◽  
Active Methylene

scholarly journals Microwave-assisted urea catalyzed Knoevenagel condensation of aldehydes with active methylene compounds

2020 ◽  
Vol 55 (2) ◽  
pp. 159-164
Author(s):  
WT Purba ◽  
PS Roy ◽  
S Jannat ◽  
SA Begum ◽  
MM Rahman
Keyword(s):  
Microwave Irradiation ◽  
Efficient Method ◽  
Knoevenagel Condensation ◽  
Efficient Catalyst ◽  
Microwave Assisted ◽  
Solvent Free Conditions ◽  
Wide Range ◽  
Active Methylene Compounds ◽  
Reaction Proceeds ◽  
Active Methylene

Rapid and efficient method for the synthesis of substituted olefins such as 2-(4-chlorophenylmethylene) malononitrile, 2-(4-hydroxyphenylmethylene) malononitrile and 2-cyano-3-(4-hydroxyphenyl) acrylamide etc under the influence of microwave irradiation are described. Urea has been utilized as an efficient catalyst for the Knoevenagel condensation of aldehydes with acidic active methylene compounds such as malononitrile, ethylcyanoacetate and cyanoacetamide to afford substituted olefins under the influence of microwave irradiation. The reaction proceeds smoothly under mild and solvent free conditions and the products are obtained in good yield. The method is applicable for a wide range of aldehydes including aromatic and heterocyclic substrates. Bangladesh J. Sci. Ind. Res.55(2), 159-164, 2020

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