Organic Reactions in Ionic Liquids: Ionic Liquids Ethylammonium Nitrate Promoted Knoevenagel Condensation of Aromatic Aldehydes with Active Methylene Compounds

2005 ◽  
Vol 35 (5) ◽  
pp. 739-744 ◽  
Author(s):  
Yi Hu ◽  
Jue Chen ◽  
Zhang‐Gao Le ◽  
Qin‐Guo Zheng
Keyword(s):  
Ionic Liquids ◽  
Knoevenagel Condensation ◽  
Aromatic Aldehydes ◽  
Organic Reactions ◽  
Ethylammonium Nitrate ◽  
Active Methylene Compounds ◽  
Active Methylene

A solvent free approach for Knoevenagel condensation: facile synthesis of 3-cyano and 3-carbethoxycoumarins

2014 ◽  
Vol 3 (3) ◽  
Author(s):  
Suresh Kumar
Keyword(s):  
Knoevenagel Condensation ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Efficient Synthesis ◽  
Facile Synthesis ◽  
Basic Alumina ◽  
Active Methylene Compounds ◽  
Active Methylene

AbstractA simple, efficient and solvent free approach for the Knoevenagel condensation has been developed which involves grinding of active methylene compounds with aromatic aldehydes over basic alumina. Using this solvent free Knoevenagel approach, a facile and efficient synthesis of 3-cyano and 3-carbethoxycoumarins has also been developed, which involves the grinding of 2-hydroxybenzaldehydes with malononitrile or ethylcyanoacetate respectively over basic alumina followed by grinding with p-toluenesulphonic acid (PTSA) in the same mortar.

Knoevenagel Reactions in Ionic Liquids

2012 ◽  
Vol 554-556 ◽  
pp. 557-561 ◽  
Author(s):  
Xiao Mei Hu ◽  
Yang Zhao ◽  
Yun Fei Gao ◽  
Yi Bo Xiao ◽  
Bi Xian Zhang
Keyword(s):  
Ionic Liquids ◽  
Large Range ◽  
Knoevenagel Condensation ◽  
Reaction Rates ◽  
Green Solvents ◽  
Efficient Procedure ◽  
Condensation Reactions ◽  
Active Methylene Compounds ◽  
High Yields ◽  
Active Methylene

Ionic liquids (ILs) as “green solvents” provided an effective and efficient procedure for Knoevenagel condensation reactions. It is applicable for a large range of aldehydes, ketones with active methylene compounds. ILs can significantly promote the reaction rates. High yields and selectivity of products have been observed. ILs can be recycled and reused. In this paper, the recent achievements of Knoevenagel condensation reactions promoted by ILs are reviewed.

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