Relations of Vitamin D Status With B-Type Natriuretic Peptide Levels and the Risk of Cardiac Events in Japanese Subjects With Heart Failure

2018 ◽  
Vol 24 (11) ◽  
pp. 803-805 ◽  
Author(s):  
Kyoko Otani ◽  
Yukie Higa ◽  
Kanako Tanaka ◽  
Hiroko Adachi ◽  
Akemi Nakazono ◽  
...  
Keyword(s):  
Heart Failure ◽  
Vitamin D ◽  
Natriuretic Peptide ◽  
Vitamin D Status ◽  
Cardiac Events ◽  
Japanese Subjects

scholarly journals Relation of Vitamin D Status to Congestive Heart Failure and Cardiovascular Events in Dogs

2013 ◽  
Vol 28 (1) ◽  
pp. 109-115 ◽  
Author(s):  
M.S. Kraus ◽  
K.M. Rassnick ◽  
J.J. Wakshlag ◽  
A.R.M. Gelzer ◽  
A.S. Waxman ◽  
...  
Keyword(s):  
Heart Failure ◽  
Vitamin D ◽  
Congestive Heart Failure ◽  
Cardiovascular Events ◽  
Vitamin D Status

Abstract P023: Relationship Between Vitamin D Status and Incidence of Macro-vascular Events in the Veterans Affairs Diabetes Trial (VADT)

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Jimmy D Alele ◽  
Kelly J Hunt ◽  
Bruce W Hollis ◽  
Deirdre K Luttrell ◽  
Louis M Luttrell ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Composite Endpoint ◽  
Cardiovascular Death ◽  
Veterans Affairs ◽  
Vitamin D Status ◽  
Primary Composite Endpoint

BACKGROUND: Few studies have examined the relationship between vitamin D levels and incident cardiovascular events in large well-characterized type 2 diabetes cohorts. METHODS: We performed prospective analyses to determine associations between vitamin D status and vascular endpoints among 936 Veterans Affairs Diabetes Trial (VADT) participants (mean age 59.7 years; 96.7% male; 40.4% minority). 25 (OH)-vitamin D was measured a median of two years after entry into the VADT study and participants were subsequently followed an average of 3.7 years for outcomes. Cox proportional hazard models were used to calculate hazard ratios (HRs) for macrovascular endpoints in relation to vitamin D quartile. The primary composite endpoint included documented myocardial infarction; stroke; death from cardiovascular causes; new or worsening congestive heart failure; surgical intervention for cardiac, cerebrovascular, or peripheral vascular disease; inoperable coronary artery disease; and amputation for ischemic gangrene. RESULTS: On average VADT participants had high cardiovascular risk at entry into the study: 65.3% of the patients recruited were obese, 38.5% had previously had a vascular event, 78.7% had hypertension and 59.5% were using statins. During follow-up, 17.2%, 5.0%, 5.9%, 2.4% and 6.6% of participants had a primary composite endpoint, myocardial infarction, chronic heart failure, cardiovascular death or all-cause death, respectively. After adjusting for age, minority status, treatment arm and history of prior event, individuals in the lowest quartile of vitamin D (i.e., 1 to 15.9 ng/ml) were at similar risk of the primary composite endpoint [HR=1.26 (95% CI: 0.81, 1.96)], myocardial infarction [HR=1.13 (95% CI: 0.53, 2.42)], congestive heart failure [HR=1.44 (95% CI: 0.67, 3.06)], cardiovascular death [HR=0.86 (95% CI: 0.28, 2.63)], and death from any cause [HR=1.04 (95% CI: 0.53, 2.04)] as individuals in the highest quartile of vitamin D (i.e., 29.9 to 77.2 ng/ml). CONCLUSIONS: These data indicate that vitamin D status had no significant impact on the incidence of macrovascular events in a cohort of high-risk veterans with type 2 diabetes mellitus in which traditional risk factors were managed according to current treatment guidelines. SUPPORT: This work was supported by American Heart Association Grant-in-Aid AHA0755466U and the Research Service of the Charleston SC VA Medical Center.

scholarly journals Brain natriuretic peptide in pregnant women with heart disease

2019 ◽  
Vol 13 (1) ◽  
pp. 25-29
Author(s):  
Karanvir Singh ◽  
Pooja Sikka ◽  
Vanita Suri ◽  
Rishikesh Prasad ◽  
Madhu Khullar ◽  
...  
Keyword(s):  
Heart Failure ◽  
Adverse Event ◽  
Heart Disease ◽  
Adverse Events ◽  
Brain Natriuretic Peptide ◽  
Pregnant Women ◽  
Natriuretic Peptide ◽  
Cardiac Events ◽  
Plasma Brain Natriuretic Peptide ◽  
Rheumatic Heart

Background Plasma brain natriuretic peptide levels were prospectively studied in pregnant women with heart disease. Methods Fifty pregnant women with heart disease and 25 controls were evaluated at 24 weeks or under, 30–32 weeks, 34 weeks or more of gestation, and 6 weeks postpartum. Adverse maternal cardiac events were hospitalization for worsening heart failure, stroke, and death. Results Thirty-eight (76%) women had rheumatic heart disease. Plasma brain natriuretic peptide levels were (in cases and controls) 118.3 ± 46.5 pg/ml and 66.3 ± 15.9 pg/ml (at 24 weeks or under), 124.8 ± 30.4 pg/ml and 68.4 ± 16.5 pg/ml (30–32 weeks), 135.8 ± 34.9 pg/ml and 68.6 ± 15.6 pg/ml (34 weeks or more), and 110.1 ± 21.9 pg/ml and 65.0 ± 16.1 pg/ml (6 weeks postpartum) (p = .0001). Eighteen women had adverse events. Of these, only 1 had a level less than 100 pg/ml, 12 were between 100 and 200 pg/ml, and 5 more than 200 pg/ml. Conclusions Plasma brain natriuretic peptide levels were higher in women with heart disease at all periods of gestation as well as six weeks postpartum. No woman with a plasma brain natriuretic peptide levels of 98 pg/ml or less had an adverse event.

scholarly journals Vitamin D status: to be considered in heart failure patients

1970 ◽  
Vol 6 (2) ◽  
pp. 65
Author(s):  
SY Ali
Keyword(s):  
Heart Failure ◽  
Vitamin D ◽  
Vitamin D Status ◽  
Heart Failure Patients

DOI: http://dx.doi.org/10.3329/fmcj.v6i2.9201 FMCJ 2011; 6(2): 65

Vitamin D Status in Patients with Atrial Fibrillation and Heart Failure - Is there a Link?

2021 ◽  
Vol 67 (06/2021) ◽  
Author(s):  
Miglena Nikolova ◽  
Neshe Nazifova-Tasinova ◽  
Deyana Vankova ◽  
Daniela Gerova ◽  
Yoto Yotov ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Vitamin D ◽  
Vitamin D Status

Patients with Congestive Heart Failure and Healthy Controls Differ in Vitamin D-Associated Lifestyle Factors

2007 ◽  
Vol 77 (4) ◽  
pp. 280-288 ◽  
Author(s):  
Zittermann ◽  
Fischer ◽  
Schleithoff ◽  
Tenderich ◽  
Fuchs ◽  
...  
Keyword(s):  
Heart Failure ◽  
Vitamin D ◽  
Congestive Heart Failure ◽  
Alcohol Consumption ◽  
Lifestyle Factors ◽  
Ultraviolet B ◽  
Controlled Study ◽  
Vitamin D Status ◽  
Large Cities ◽  
Uvb Exposure

We have recently hypothesized that low vitamin D status may contribute to the pathogenesis of congestive heart failure (CHF). This study was aimed at evaluating, in a pilot study, whether CHF patients have indications for a low vitamin D status during earlier periods of their lives. We performed a case-controlled study in 150 CHF patients and 150 controls. Study participants had to answer a questionnaire that included several items concerning vitamin D-associated lifestyle factors during childhood, adolescence, and adulthood. A vitamin D score was constructed. This score takes into consideration that ultraviolet-B (UVB) exposure is the major vitamin D source for humans and that those lifestyle factors, which are associated with regular UVB exposure, can guarantee an adequate vitamin D status at best. The vitamin D score was significantly higher in controls than in patients (p < 0.001). Compared with the controls, more patients lived in large cities (p < 0.001), fewer patients were members of a sport club (p < 0.001), and fewer patients had summer holidays every year (p < 0.01). Patients also reported significantly less alcohol consumption during adulthood than controls (p < 0.001). Our results demonstrate that CHF patients and controls differed in several vitamin D-associated lifestyle factors and in alcohol consumption during earlier periods of their lives.

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