Synthesis and evaluation of hyaluronic acid–poly(ethylene oxide) hydrogel via Michael-type addition reaction

2007 ◽  
Vol 7 ◽  
pp. e28-e32 ◽  
Author(s):  
Gun-Woo Kim ◽  
Yoon-Jeong Choi ◽  
Mi-Sook Kim ◽  
Yongdoo Park ◽  
Kyu-Back Lee ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Ethylene Oxide ◽  
Addition Reaction ◽  
Michael Type Addition ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

scholarly journals New Hyaluronic Acid/Polyethylene Oxide-Based Electrospun Nanofibers: Design, Characterization and In Vitro Biological Evaluation

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1291
Author(s):  
Oana Maria Ionescu ◽  
Arn Mignon ◽  
Andreea Teodora Iacob ◽  
Natalia Simionescu ◽  
Luminita Georgeta Confederat ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Ethylene Oxide ◽  
Transmission Rate ◽  
Biological Evaluation ◽  
Wound Dressings ◽  
Calendula Officinalis ◽  
Active Components ◽  
Poly Ethylene Oxide ◽  
Nanofiber Membranes ◽  
Poly Ethylene

Natural compounds have been used as wound-healing promoters and are also present in today’s clinical proceedings. In this research, different natural active components such as propolis, Manuka honey, insulin, L-arginine, and Calendula officinalis infusion were included into hyaluronic acid/poly(ethylene)oxide-based electrospun nanofiber membranes to design innovative wound-dressing biomaterials. Morphology and average fiber diameter were analyzed by scanning electron microscopy. Chemical composition was proved by Fourier transform infrared spectroscopy, which indicated successful incorporation of the active components. The nanofiber membranes with propolis and Calendula officinalis showed best antioxidant activity, cytocompatibility, and antimicrobial properties against pathogen strains Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa and had an average diameter of 217 ± 19 nm with smooth surface aspect. Water vapor transmission rate was in agreement with the range suitable for preventing infections or wound dehydration (~5000 g/m2 24 h). Therefore, the developed hyaluronic acid/poly(ethylene)oxide nanofibers with additional natural components showed favorable features for clinical use as wound dressings.

Characterization of Hyaluronic Acid-Poly(Ethylene Oxide) Hydrogel Dependent upon Poly(Ethylene Oxide)

2007 ◽  
pp. 749-752
Author(s):  
Mi Sook Kim ◽  
Yoon Jeong Choi ◽  
Gun Woo Kim ◽  
In Sup Noh ◽  
Yong Doo Park ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Ethylene Oxide ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Synthesis and characterization of novel dumbbell shaped copolymers poly(ethylene oxide)x-b-polystyrene-b-poly(ethylene oxide)x with tunable side arms by combination of efficient thiol-ene addition reaction with living polymerization mechanism

RSC Advances ◽  
2015 ◽  
Vol 5 (41) ◽  
pp. 32358-32368 ◽  
Author(s):  
Lingdi Chen ◽  
Jian Huang ◽  
Xuepu Wang ◽  
Chengjiao Lu ◽  
Hongdong Zhang ◽  
...  
Keyword(s):  
Ethylene Oxide ◽  
Addition Reaction ◽  
Living Polymerization ◽  
Synthesis And Characterization ◽  
Synthetic Route ◽  
Polymerization Mechanism ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene ◽  
Ene Addition

A series of well-defined dumbbell shaped copolymers consisting of PEO and PS segments were successfully synthesized by LAP and ROP mechanisms and the efficient thiol-ene addition reaction. This versatile synthetic route might be used to synthesize other similar copolymers.

Characterization of Hyaluronic Acid-Poly(Ethylene Oxide) Hydrogel Dependent upon Poly(Ethylene Oxide)

2007 ◽  
Vol 342-343 ◽  
pp. 749-752
Author(s):  
Mi Sook Kim ◽  
Yoon Jeong Choi ◽  
Gun Woo Kim ◽  
In Sup Noh ◽  
Yong Doo Park ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Ethylene Oxide ◽  
Thiol Groups ◽  
Molecular Weights ◽  
Hydrogel Network ◽  
End Groups ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene ◽  
Surface Morphologies

Characterization of an hyaluronic acid (HA)-poly(ethylene oxide) (PEO) hydrogel was performed by changing the number of side arms in a PEO molecule. Verification of grafting chemistry and mechanical strength, as well as swelling behaviors and surface morphologies of the HA-PEO hydrogels were analyzed by employing different x-linking molecular weights (MW) of PEO ranging from 1.7 to 5.0 kDa at a fixed low MW HA in the hydrogel network. Methacrylation to the HA successfully obtained via Michael type reaction between the methacrylate arm groups in HA and the thiol end groups in PEO was observed by XPS. Hydrogel formation was markedly dependent upon the numbers of thiol groups in the PEO molecule. Furthermore the lower MW PEO-based HA hydrogel demonstrated stronger mechanical properties but lower water absorption and the smaller pore sizes on its surface and cross section.

Effects of cross-linking molecular weights in a hyaluronic acid–poly(ethylene oxide) hydrogel network on its properties

2006 ◽  
Vol 1 (3) ◽  
pp. 116-123 ◽  
Author(s):  
Insup Noh ◽  
Gun-Woo Kim ◽  
Yoon-Jeong Choi ◽  
Mi-Sook Kim ◽  
Yongdoo Park ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Ethylene Oxide ◽  
Cross Linking ◽  
Molecular Weights ◽  
Hydrogel Network ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Effect of Hydroxyapatite-Tricalcium Phosphate Micro-Particles on the Cellular Interaction of In Situ Hyaluronic Acid-Poly(Ethylene Oxide) Hydrogel

2007 ◽  
Vol 342-343 ◽  
pp. 765-768
Author(s):  
Mi Sook Kim ◽  
Yoon Jeong Choi ◽  
Gun Woo Kim ◽  
In Sup Noh ◽  
Yong Doo Park ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Ethylene Oxide ◽  
Tricalcium Phosphate ◽  
Particle Surface ◽  
Cellular Interaction ◽  
Micro Particles ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

In vitro cell behaviors of calvarial osteoblasts (MC3T3) were evaluated by seeding them on both the surface and inside of in situ hyaluronic acid-poly(ethylene oxide) (HA-PEO) hydrogel, either after or before incorporation of mixture micro-particles of hydroxyapatite-β-tricalcium phosphate on/inside the hydrogel, respectively. Cellular behaviors such as adhesion and proliferation on the surface and inside the gel were evaluated with light microscopy and a microplate reader by focusing on the interactions of cell-HA-PEO as well as cell-hydroxyapatitetricalcium phosphate micro-particle surface in the gel. Cell adhesion and spreading seemed to be enhanced by supplying the micro-particles to the inside the HA-PEO hydrogel, compared to the results of the HA-PEO hydrogel itself.

Sign in / Sign up

Export Citation Format

Share Document