HMGB-1 induces cell motility and α5β1 integrin expression in human chondrosarcoma cells

2012 ◽  
Vol 322 (1) ◽  
pp. 98-106 ◽  
Author(s):  
Chih-Hsin Tang ◽  
Yun-Ting Keng ◽  
Ju-Fang Liu
Keyword(s):  
Cell Motility ◽  
Integrin Expression ◽  
Human Chondrosarcoma ◽  
Α5β1 Integrin

IGF-I enhances α5β1 integrin expression and cell motility in human chondrosarcoma cells

2011 ◽  
Vol 226 (12) ◽  
pp. 3270-3277 ◽  
Author(s):  
Chi-Ming Wu ◽  
Te-Mao Li ◽  
Sheng-Feng Hsu ◽  
Yi-Chang Su ◽  
Shung-Te Kao ◽  
...  
Keyword(s):  
Cell Motility ◽  
Integrin Expression ◽  
Human Chondrosarcoma ◽  
Igf I ◽  
Α5β1 Integrin

IL-8 increases integrin expression and cell motility in human chondrosarcoma cells

2011 ◽  
Vol 112 (9) ◽  
pp. 2549-2557 ◽  
Author(s):  
Chun-Yi Lee ◽  
Chun-Yin Huang ◽  
Meng-Yi Chen ◽  
Ching-Yuang Lin ◽  
Horng-Chaung Hsu ◽  
...  
Keyword(s):  
Cell Motility ◽  
Integrin Expression ◽  
Human Chondrosarcoma

scholarly journals Amphiregulin enhances alpha6beta1 integrin expression and cell motility in human chondrosarcoma cells through Ras/Raf/MEK/ERK/AP-1 pathway

Oncotarget ◽  
2015 ◽  
Vol 6 (13) ◽  
pp. 11434-11446 ◽  
Author(s):  
Jui-Chieh Chen ◽  
Yu-Ju Chen ◽  
Chih-Yang Lin ◽  
Yi-Chin Fong ◽  
Chin-Jung Hsu ◽  
...  
Keyword(s):  
Cell Motility ◽  
Integrin Expression ◽  
Human Chondrosarcoma

scholarly journals Correction: Amphiregulin enhances alpha6beta1 integrin expression and cell motility in human chondrosarcoma cells through Ras/Raf/MEK/ERK/AP-1 pathway

Oncotarget ◽  
2017 ◽  
Vol 8 (15) ◽  
pp. 25830-25830
Author(s):  
Jui-Chieh Chen ◽  
Yu-Ju Chen ◽  
Chih-Yang Lin ◽  
Yi-Chin Fong ◽  
Chin-Jung Hsu ◽  
...  
Keyword(s):  
Cell Motility ◽  
Integrin Expression ◽  
Human Chondrosarcoma

scholarly journals Absence of the αvβ3 Integrin Dictates the Time-Course of Angiogenesis in the Hypoxic Central Nervous System: Accelerated Endothelial Proliferation Correlates with Compensatory Increases in α5β1 Integrin Expression

2010 ◽  
Vol 30 (5) ◽  
pp. 1031-1043 ◽  
Author(s):  
Longxuan Li ◽  
Jennifer V Welser ◽  
Richard Milner
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Time Course ◽  
Αvβ3 Integrin ◽  
Integrin Expression ◽  
Brain Endothelial Cells ◽  
Endothelial Proliferation ◽  
Β3 Integrin ◽  
Α5β1 Integrin

Cerebral angiogenesis is an important adaptive response to hypoxia. As the αvβ3 integrin is induced on angiogenic vessels in the ischemic central nervous system (CNS), and the suggested angiogenic role for this integrin in other systems, it is important to determine whether the αvβ3 integrin is an important mediator of cerebral angiogenesis. αvβ3 integrin expression was examined in a model of cerebral hypoxia, in which mice were subject to hypoxia (8% O2) for 0, 4, 7, or 14 days. Immunofluorescence and western blot analysis revealed that in the hypoxic CNS, αvβ3 integrin was strongly induced on angiogenic brain endothelial cells (BEC), along with its ligand vitronectin. In the hypoxia model, β3 integrin-null mice showed no obvious defect in cerebral angiogenesis. However, early in the angiogenic process, BEC in these mice showed an increased mitotic index that correlated closely with increased α5 integrin expression. In vitro experiments confirmed α5 integrin upregulation on β3 integrin-null BEC, which also correlated with increased BEC proliferation on fibronectin. These studies confirm hypoxic induction of αvβ3 integrin on angiogenic vessels, but suggest distinct roles for the BEC integrins αvβ3 and α5β1 in cerebral angiogenesis, with αvβ3 having a nonessential role, and α5β1 promoting BEC proliferation.

Stromal cell-derived factor-1 increase αvβ3 integrin expression and invasion in human chondrosarcoma cells

2009 ◽  
Vol 218 (2) ◽  
pp. 334-342 ◽  
Author(s):  
Tzu-Hsiu Lai ◽  
Yi-Chin Fong ◽  
Wen-Mei Fu ◽  
Rong-Sen Yang ◽  
Chih-Hsin Tang
Keyword(s):  
Stromal Cell ◽  
Αvβ3 Integrin ◽  
Integrin Expression ◽  
Human Chondrosarcoma ◽  
Stromal Cell Derived Factor

CCN6 enhances ICAM-1 expression and cell motility in human chondrosarcoma cells

2011 ◽  
Vol 227 (1) ◽  
pp. 223-232 ◽  
Author(s):  
Yi-Chin Fong ◽  
Chih-Yang Lin ◽  
Yi-Chang Su ◽  
Wen-Chi Chen ◽  
Fuu-Jen Tsai ◽  
...  
Keyword(s):  
Cell Motility ◽  
Human Chondrosarcoma
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