Stromal cell-derived factor-1 increase αvβ3 integrin expression and invasion in human chondrosarcoma cells

2009 ◽  
Vol 218 (2) ◽  
pp. 334-342 ◽  
Author(s):  
Tzu-Hsiu Lai ◽  
Yi-Chin Fong ◽  
Wen-Mei Fu ◽  
Rong-Sen Yang ◽  
Chih-Hsin Tang
Keyword(s):  
Stromal Cell ◽  
Αvβ3 Integrin ◽  
Integrin Expression ◽  
Human Chondrosarcoma ◽  
Stromal Cell Derived Factor

scholarly journals BMP-7 Enhances Cell Migration and αvβ3 Integrin Expression via a c-Src-Dependent Pathway in Human Chondrosarcoma Cells

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e112636 ◽  
Author(s):  
Jui-Chieh Chen ◽  
Shu-Ting Yang ◽  
Chih-Yang Lin ◽  
Chin-Jung Hsu ◽  
Chun-Hao Tsai ◽  
...  
Keyword(s):  
Cell Migration ◽  
Αvβ3 Integrin ◽  
Integrin Expression ◽  
Human Chondrosarcoma ◽  
Dependent Pathway

TNF-α increases αvβ3 integrin expression and migration in human chondrosarcoma cells

2010 ◽  
Vol 226 (3) ◽  
pp. 792-799 ◽  
Author(s):  
Chun-Han Hou ◽  
Rong-Sen Yang ◽  
Sheng-Mou Hou ◽  
Chih-Hsin Tang
Keyword(s):  
Αvβ3 Integrin ◽  
Integrin Expression ◽  
Human Chondrosarcoma ◽  
Tnf Α ◽  
And Migration

scholarly journals Stromal Cell-Derived Factor-1 Is Essential for Photoreceptor Cell Protection in Retinal Detachment

2010 ◽  
Vol 177 (5) ◽  
pp. 2268-2277 ◽  
Author(s):  
Hiroki Otsuka ◽  
Noboru Arimura ◽  
Shozo Sonoda ◽  
Makoto Nakamura ◽  
Teruto Hashiguchi ◽  
...  
Keyword(s):  
Retinal Detachment ◽  
Stromal Cell ◽  
Photoreceptor Cell ◽  
Cell Protection ◽  
Stromal Cell Derived Factor

scholarly journals Stromal Cell-Derived Factor 1α (SDF-1α) in Invasive Breast Cancer: Associations with Vasculo-Angiogenic Factors and Prognostic Significance

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1952
Author(s):  
Elżbieta Zarychta ◽  
Barbara Ruszkowska-Ciastek ◽  
Kornel Bielawski ◽  
Piotr Rhone
Keyword(s):  
Breast Cancer ◽  
Invasive Breast Cancer ◽  
Stromal Cell ◽  
Prognostic Significance ◽  
Disease Free Survival ◽  
Breast Cancer Patients ◽  
Roc Curve Analysis ◽  
Stromal Cell Derived Factor ◽  
A Prospective Study

(1) Background: Tumour angiogenesis is critical for the progression of neoplasms. A prospective study was designed to examine the utility of stromal cell-derived factor 1α (SDF-1α) and selected vasculo-angiogenic parameters for estimating the probability of disease relapse in 84 primary, operable invasive breast cancer (IBrC) patients (40 (48%) with stage IA and 44 (52%) with stage IIA and IIB). (2) Methods: We explored the prognostic value of the plasma levels of SDF-1α, vascular endothelial growth factor A (VEGF-A), the soluble forms of VEGF receptors type 1 and 2, and the number of circulating endothelial progenitor cells (circulating EPCs) in breast cancer patients. The median follow-up duration was 58 months, with complete follow-up for the first event. (3) Results: According to ROC curve analysis, the optimal cut-off point for SDF-1α (for discriminating between patients at high and low risk of relapse) was 42 pg/mL, providing 57% sensitivity and 75% specificity. Kaplan–Meier curves for disease-free survival (DFS) showed that concentrations of SDF-1α lower than 42 pg/dL together with a VEGFR1 lower than 29.86 pg/mL were significantly associated with shorter DFS in IBrC patients (p = 0.0381). Patients with both SDF-1α lower than 42 pg/dL and a number of circulating EPCs lower than 9.68 cells/µL had significantly shorter DFS (p = 0.0138). (4) Conclusions: Our results imply the clinical usefulness of SDF-1α, sVEGFR1 and the number of circulating EPCs as prognostic markers for breast cancer in clinical settings.

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