Adaptive fuzzy back-stepping control of drug dosage regimen in cancer treatment

2018 ◽  
Vol 42 ◽  
pp. 267-276 ◽  
Author(s):  
Hajar Nasiri ◽  
Ali Akbarzadeh Kalat
1973 ◽  
Vol 7 (9) ◽  
pp. 382-387 ◽  
Author(s):  
Donald L. Giusti ◽  
William L. Hayton

A pharmacokinetic approach based on creatinine clearance has been outlined which permits drug dosage regimen adjustments in patients with renal impairment. The parameters needed for calculating a loading dose and a maintenance regimen are the fraction of a dose excreted unchanged in the urine, the creatinine clearance of the patient, and the half-life of the drug in patients with normal renal function. In varying degrees of renal failure, predicted dosage regimens agree closely with dosage regimens predicted by other methods for a number of drugs.


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