Risk assessment of adverse pulmonary effects induced by adrenaline β-receptor antagonists and rational drug dosage regimen based on receptor occupancy

1995 ◽  
Vol 23 (5) ◽  
pp. 463-478 ◽  
Author(s):  
Yasuhiko Yamada ◽  
Kyoko Matsuyama ◽  
Kiyomi Ito ◽  
Yasufumi Sawada ◽  
Tatsuji Iga
Keyword(s):  
Risk Assessment ◽  
Dosage Regimen ◽  
Receptor Occupancy ◽  
Drug Dosage ◽  
Receptor Antagonists ◽  
Rational Drug ◽  
Β Receptor ◽  
Drug Dosage Regimen

Dosage Regimen Adjustments in Renal Impairment

1973 ◽  
Vol 7 (9) ◽  
pp. 382-387 ◽  
Author(s):  
Donald L. Giusti ◽  
William L. Hayton
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Renal Impairment ◽  
Creatinine Clearance ◽  
Dosage Regimen ◽  
Drug Dosage ◽  
Loading Dose ◽  
Dosage Regimens ◽  
Drug Dosage Regimen ◽  
Pharmacokinetic Approach

A pharmacokinetic approach based on creatinine clearance has been outlined which permits drug dosage regimen adjustments in patients with renal impairment. The parameters needed for calculating a loading dose and a maintenance regimen are the fraction of a dose excreted unchanged in the urine, the creatinine clearance of the patient, and the half-life of the drug in patients with normal renal function. In varying degrees of renal failure, predicted dosage regimens agree closely with dosage regimens predicted by other methods for a number of drugs.

Pharmacokinetics of Antimicrobial Agents

1984 ◽  
Vol 5 (2) ◽  
pp. 95-97
Author(s):  
Sandra M. Norris ◽  
Daniel A. Spyker
Keyword(s):  
Drug Concentration ◽  
Dosage Regimen ◽  
Time Course ◽  
Antimicrobial Agents ◽  
Drug Distribution ◽  
Pharmacokinetic Profile ◽  
Drug Dosage ◽  
Blood Levels ◽  
Rational Drug ◽  
Antiinfective Agents

The association between a target serum concentration and the therapeutic and toxic effects of most antiinfective agents is sufficiently established that we routinely use antibiotic blood levels as objective markers of therapy. Pharmacokinetics is the study of the time course of drug distribution throughout a biological system. Thus, we examine the effect of drug availability, distribution, metabolism, and clearance on drug concentration in various fluids and tissues. A principal goal is rational drug dosage selection and dosage adjustment. The use of mathematical expressions which characterize these metabolic processes enhances the clinician's ability to manipulate the dosage regimen to achieve and maintain a desired drug concentration at the site of action while minimizing toxicity. Knowledge of a drug's pharmacokinetic profile provides the basis for the design of a drug dosage regimen.

Drugs from emasculated hormones: The principle of syntopic antagonism

1989 ◽  
Vol 9 (3) ◽  
pp. 253-272 ◽  
Author(s):  
James Black
Keyword(s):  
Future Research ◽  
Receptor Antagonists ◽  
Personal View ◽  
H2 Receptor Antagonists ◽  
Histamine H2 Receptor ◽  
H2 Receptor ◽  
Early Stages ◽  
Β Receptor

This lecture outlines the early stages in the discovery of adrenaline β-receptor antagonists and of the histamine H2-receptor antagonists. It ends with a brief personal view about future research.

Sign in / Sign up

Export Citation Format

Share Document