Conditioning the Cortical Silent Period with Paired Transcranial Magnetic Stimulation

2013 ◽  
Vol 6 (4) ◽  
pp. 541-544 ◽  
Author(s):  
Benjamin I. Silbert ◽  
Gary W. Thickbroom
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Silent Period ◽  
Cortical Silent Period

Prolonged cortical silent period after transcranial magnetic stimulation in generalized epilepsy

Neurology ◽  
2001 ◽  
Vol 57 (4) ◽  
pp. 706-708 ◽  
Author(s):  
R. A.L. Macdonell ◽  
M. A. King ◽  
M. R. Newton ◽  
J. M. Curatolo ◽  
D. C. Reutens ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Silent Period ◽  
Cortical Silent Period ◽  
Generalized Epilepsy

Prolonged cortical silent period after transcranial magnetic stimulation in generalized epilepsy

Neurology ◽  
2002 ◽  
Vol 58 (7) ◽  
pp. 1135-1136 ◽  
Author(s):  
R. Cantello ◽  
R.A. L. Macdonell ◽  
M.A. King ◽  
M.R. Newton ◽  
J.M. Curatolo ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Silent Period ◽  
Cortical Silent Period ◽  
Generalized Epilepsy

scholarly journals Prominent Prolongation of Cortical Silent Period Induced by Transcranial Magnetic Stimulation in Creutzfeldt-Jakob Disease

2020 ◽  
Vol 12 (3) ◽  
pp. 447-451
Author(s):  
Hideyuki Matsumoto ◽  
Naohiro Uchio ◽  
Akihito Hao ◽  
Mari Haga ◽  
Chiaki Abe ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Early Stage ◽  
Brain Magnetic Resonance Imaging ◽  
Silent Period ◽  
Progressive Dementia ◽  
Cortical Silent Period ◽  
Diffusion Weighted Images ◽  
Jakob Disease ◽  
Early Biomarker

The cortical silent period (CSP) induced by transcranial magnetic stimulation (TMS) has been reported to be prolonged in 2 Creutzfeldt-Jakob disease (CJD) patients who presented with periodic myoclonus. Herein, we will show a prominent prolongation of TMS-induced CSP in a patient with CJD who did not have periodic myoclonus. The patient was a 66-year-old woman who developed rapidly progressive dementia. No myoclonic jerks were observed. Brain magnetic resonance imaging showed high-intensity lesions in the cerebral cortex, basal ganglia, and thalamus on diffusion-weighted images. Electroencephalography (EEG) showed diffuse and continuous slow waves, but no periodic synchronous discharges (PSDs). A TMS study revealed that the duration of CSP was prominently prolonged: the duration of CSP (370 ms) equaled that of the mean + 6.5 SD of the normal value. One month after admission, the patient exhibited akinetic mutism and developed periodic myoclonus in her limbs. The clinical course was compatible with CJD. To date, CSP has been measured in only 2 CJD patients. The common findings in both cases were marked prolongation of CSP, periodic myoclonus, and PSD on EEG. In short, we demonstrated that TMS-induced CSP was prominently prolonged even at the early stage of CJD without periodic myoclonus or PSD. In other disorders, the CSP has not been reported to be comparably prolonged to that of CJD patients. Therefore, we conclude that TMS-induced CSP could be prominently prolonged even in the early stage of CJD. The marked prolongation of the CSP might be an early biomarker of CJD.

Transcranial magnetic stimulation reduces masseter motoneuron pool excitability throughout the cortical silent period

2008 ◽  
Vol 119 (5) ◽  
pp. 1119-1129 ◽  
Author(s):  
Paul F. Sowman ◽  
Stanley C. Flavel ◽  
Christie L. McShane ◽  
Timothy S. Miles ◽  
Michael A. Nordstrom
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Silent Period ◽  
Cortical Silent Period ◽  
Motoneuron Pool

The effect of acetaminophen ingestion on cortico-spinal excitability

2013 ◽  
Vol 91 (2) ◽  
pp. 187-189 ◽  
Author(s):  
Alexis R. Mauger ◽  
James G. Hopker
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Evoked Potential ◽  
Motor Evoked Potential ◽  
Silent Period ◽  
Sodium Currents ◽  
Cortical Silent Period ◽  
Voltage Gated ◽  
Spinal Excitability

Acetaminophen (ACT) facilitates the inhibition of voltage-gated calcium and sodium currents, which may effect cortico-spinal excitability. Twelve subjects ingested acetaminophen or a placebo and underwent transcranial magnetic stimulation to assess the motor evoked potential (MEP), and cortical silent period (CSP). ACT significantly increased MEP response (P > 0.05) but had no effect on CSP (P > 0.05). This indicates that ACT increases MEP and should be controlled for in studies where these measures are of interest.

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