The effect of acetaminophen ingestion on cortico-spinal excitability

2013 ◽  
Vol 91 (2) ◽  
pp. 187-189 ◽  
Author(s):  
Alexis R. Mauger ◽  
James G. Hopker
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Evoked Potential ◽  
Motor Evoked Potential ◽  
Silent Period ◽  
Sodium Currents ◽  
Cortical Silent Period ◽  
Voltage Gated ◽  
Spinal Excitability

Acetaminophen (ACT) facilitates the inhibition of voltage-gated calcium and sodium currents, which may effect cortico-spinal excitability. Twelve subjects ingested acetaminophen or a placebo and underwent transcranial magnetic stimulation to assess the motor evoked potential (MEP), and cortical silent period (CSP). ACT significantly increased MEP response (P > 0.05) but had no effect on CSP (P > 0.05). This indicates that ACT increases MEP and should be controlled for in studies where these measures are of interest.

Prolonged cortical silent period after transcranial magnetic stimulation in generalized epilepsy

Neurology ◽  
2001 ◽  
Vol 57 (4) ◽  
pp. 706-708 ◽  
Author(s):  
R. A.L. Macdonell ◽  
M. A. King ◽  
M. R. Newton ◽  
J. M. Curatolo ◽  
D. C. Reutens ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Silent Period ◽  
Cortical Silent Period ◽  
Generalized Epilepsy

Transcranial magnetic stimulation

2016 ◽  
Author(s):  
Kerry R. Mills
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Motor Neurons ◽  
Magnetic Stimulation ◽  
Motor Evoked Potential ◽  
Silent Period ◽  
Demyelinating Diseases ◽  
Conduction Time ◽  
Spinal Motor Neurons ◽  
Basic Physics ◽  
Clinical Measures

Transcranial magnetic stimulation (TMS) has been exploited to advance knowledge of corticospinal physiology and, in a number of conditions, to aid diagnosis and quantify corticospinal abnormalities. The basic physics of magnetic stimulation is described along with the effects of stimulating coils with different dimensions and shape. The effects of single TMS pulses over motor cortex to cause a descending volley of D and I waves, and their effects on spinal motor neurons resulting in a motor evoked potential (MEP) are described. Guidelines for the safe use of TMS are given. Methods to estimate useful clinical measures of corticospinal function, such as threshold, MEP amplitude, central motor conduction time, silent period and input:output relation are given, as is the means to quantify corticospinal conduction using the triple stimulation technique. The clinical utility of TMS in neurodegenerations, central demyelinating diseases, stroke, spinal cord disease, movement disorders, and functional disorders is discussed.

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