The synthetic ceramide analog l-PDMP partially protects striatal dopamine levels but does not promote dopamine neuron survival in murine models of parkinsonism

2006 ◽  
Vol 1099 (1) ◽  
pp. 199-205 ◽  
Author(s):  
J.S. Schneider ◽  
K.A. Bradbury ◽  
Yoshihiro Anada ◽  
Jin-ichi Inokuchi ◽  
D.W. Anderson
Keyword(s):  
Dopamine Neuron ◽  
Striatal Dopamine ◽  
Murine Models ◽  
Neuron Survival

Rat fetal ventral mesencephalon grown as solid tissue cultures: influence of culture time and BDNF treatment on dopamine neuron survival and function

1998 ◽  
Vol 813 (2) ◽  
pp. 313-322 ◽  
Author(s):  
Günter U Höglinger ◽  
Jürgen Sautter ◽  
Morten Meyer ◽  
Christian Spenger ◽  
Rolf W Seiler ◽  
...  
Keyword(s):  
Dopamine Neuron ◽  
Tissue Cultures ◽  
Ventral Mesencephalon ◽  
Neuron Survival ◽  
Solid Tissue ◽  
Culture Time ◽  
And Function

IGF-I and bFGF Improve Dopamine Neuron Survival and Behavioral Outcome in Parkinsonian Rats Receiving Cultured Human Fetal Tissue Strands

2001 ◽  
Vol 168 (1) ◽  
pp. 183-191 ◽  
Author(s):  
Edward D. Clarkson ◽  
W.Michael Zawada ◽  
K.Pat Bell ◽  
James E. Esplen ◽  
Paul K. Choi ◽  
...  
Keyword(s):  
Fetal Tissue ◽  
Dopamine Neuron ◽  
Behavioral Outcome ◽  
Neuron Survival ◽  
Human Fetal Tissue ◽  
Igf I

scholarly journals Effects of ex vivo transduction of mesencephalic reaggregates with bcl-2 on grafted dopamine neuron survival

2007 ◽  
Vol 1134 ◽  
pp. 33-44 ◽  
Author(s):  
Caryl E. Sortwell ◽  
William J. Bowers ◽  
Scott E. Counts ◽  
Mark R. Pitzer ◽  
Matthew F. Fleming ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Dopamine Neuron ◽  
Neuron Survival

scholarly journals Striatal dopamine explains novelty-induced behavioral dynamics and individual variability in threat prediction

2021 ◽  
Author(s):  
Korleki Akiti ◽  
Iku Tsutsui-Kimura ◽  
Yudi Xie ◽  
Alexander Mathis ◽  
Jeffrey Markowitz ◽  
...  
Keyword(s):  
Reinforcement Learning ◽  
Behavioral Responses ◽  
Individual Variability ◽  
Dopamine Neuron ◽  
Striatal Dopamine ◽  
Prediction Errors ◽  
Characteristic Sequence ◽  
Point Tracking ◽  
Behavioral Dynamics ◽  
Influence Behavior

Animals exhibit diverse behavioral responses, such as exploration and avoidance, to novel cues in the environment. However, it remains unclear how dopamine neuron-related novelty responses influence behavior. Here, we characterized dynamics of novelty exploration using multi-point tracking (DeepLabCut) and behavioral segmentation (MoSeq). Novelty elicits a characteristic sequence of behavior, starting with investigatory approach and culminating in object engagement or avoidance. Dopamine in the tail of striatum (TS) suppresses engagement, and dopamine responses were predictive of individual variability in behavior. Behavioral dynamics and individual variability were explained by a novel reinforcement learning (RL) model of threat prediction, in which behavior arises from a novelty-induced initial threat prediction (akin to shaping bonus), and a threat prediction that is learned through dopamine-mediated threat prediction errors. These results uncover an algorithmic similarity between reward- and threat-related dopamine sub-systems.

scholarly journals The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival

Cell ◽  
2018 ◽  
Vol 174 (6) ◽  
pp. 1436-1449.e20 ◽  
Author(s):  
Celine I. Maeder ◽  
Jae-Ick Kim ◽  
Xing Liang ◽  
Konstantin Kaganovsky ◽  
Ao Shen ◽  
...  
Keyword(s):  
Dopamine Neuron ◽  
Synapse Development ◽  
Neuron Survival ◽  
Tho Complex

scholarly journals A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Ting Zhou ◽  
Tae Wan Kim ◽  
Chi Nok Chong ◽  
Lei Tan ◽  
Sadaf Amin ◽  
...  
Keyword(s):  
Dopamine Neuron ◽  
Β Cell ◽  
Neuron Survival ◽  
Gene Environment
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