IGF-I and bFGF Improve Dopamine Neuron Survival and Behavioral Outcome in Parkinsonian Rats Receiving Cultured Human Fetal Tissue Strands

2001 ◽  
Vol 168 (1) ◽  
pp. 183-191 ◽  
Author(s):  
Edward D. Clarkson ◽  
W.Michael Zawada ◽  
K.Pat Bell ◽  
James E. Esplen ◽  
Paul K. Choi ◽  
...  
Keyword(s):  
Fetal Tissue ◽  
Dopamine Neuron ◽  
Behavioral Outcome ◽  
Neuron Survival ◽  
Human Fetal Tissue ◽  
Igf I

Neural Tissue Xenotransplantation: What is Needed Prior to Clinical Trials in Parkinson's Disease?

2000 ◽  
Vol 9 (2) ◽  
pp. 235-246 ◽  
Author(s):  
Roger A. Barker ◽  
A. Lisa Kendall ◽  
Håkan Widner ◽  
H. Widner ◽  
L. Larsson ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Trials ◽  
Human Tissue ◽  
Neural Tissue ◽  
Fetal Tissue ◽  
Suitable Material ◽  
Human Fetal Tissue ◽  
Critical Issues ◽  
Alternative Sources

Embryonic allografted human tissue in patients with Parkinson's disease has been shown to survive and ameliorate many of the symptoms of this disease. Despite this success, the practical problems of using this tissue coupled to the ethical restrictions of using aborted human fetal tissue have lead to an exploration for alternative sources of suitable material for grafting, including xenogeneic embryonic dopaminergic-rich neural tissue. Nevertheless, xenografted neural tissue itself generates a number of practical, ethical, safety, and immunological issues that have to be addressed prior to any clinical xenotransplant program. In this article we review these critical issues and set out the criteria that we consider need to be met in the development of our clinical xenotransplantation research programs. We advocate that these, or similar, criteria should be adopted and made explicit by other centers contemplating similar clinical trials.

Transplantation of human fetal tissue in hematology

1994 ◽  
Vol 117 (4) ◽  
pp. 376-378 ◽  
Author(s):  
G. T. Sukhikh ◽  
E. M. Molnar ◽  
V. V. Malaitsev ◽  
I. M. Bogdanova
Keyword(s):  
Fetal Tissue ◽  
Human Fetal Tissue

Utility of Fragmented Human Fetal Tissue as a Potential Dopaminergic Brain Graft in Parkinson's Disease

1993 ◽  
Vol 61 (1) ◽  
pp. 1-11 ◽  
Author(s):  
R.I. HogenEsch ◽  
M.J. Staal ◽  
I.P. Kema ◽  
C.H.C.M. Buys ◽  
K.G. Go
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Fetal Tissue ◽  
Human Fetal Tissue

The ethics of research using human fetal tissue: reply (ii)

Health Policy ◽  
1990 ◽  
Vol 16 (2) ◽  
pp. 175
Author(s):  
H.T. Greely ◽  
T. Raffin
Keyword(s):  
Fetal Tissue ◽  
Human Fetal Tissue ◽  
Ethics Of Research

Rat fetal ventral mesencephalon grown as solid tissue cultures: influence of culture time and BDNF treatment on dopamine neuron survival and function

1998 ◽  
Vol 813 (2) ◽  
pp. 313-322 ◽  
Author(s):  
Günter U Höglinger ◽  
Jürgen Sautter ◽  
Morten Meyer ◽  
Christian Spenger ◽  
Rolf W Seiler ◽  
...  
Keyword(s):  
Dopamine Neuron ◽  
Tissue Cultures ◽  
Ventral Mesencephalon ◽  
Neuron Survival ◽  
Solid Tissue ◽  
Culture Time ◽  
And Function

The ethics of research using human fetal tissue: (II)

Health Policy ◽  
1990 ◽  
Vol 16 (2) ◽  
pp. 175
Author(s):  
D.E. Redmond ◽  
D. Spencer ◽  
F. Naftolin ◽  
R.H. Roth ◽  
B.S. Bunney ◽  
...  
Keyword(s):  
Fetal Tissue ◽  
Human Fetal Tissue ◽  
Ethics Of Research

Transplantation of Electively Aborted Human Fetal Tissue

1995 ◽  
Vol 50 (3) ◽  
pp. 185-187
Author(s):  
Michelle A. Mullen ◽  
J. Ivan Williams ◽  
Frederick H. Lowy
Keyword(s):  
Fetal Tissue ◽  
Human Fetal Tissue

scholarly journals Identification and characterization of neuronal precursors and their progeny from human fetal tissue

2001 ◽  
Vol 66 (3) ◽  
pp. 356-368 ◽  
Author(s):  
David R. Piper ◽  
Tahmina Mujtaba ◽  
Hansoo Keyoung ◽  
Neeta S. Roy ◽  
Steven A. Goldman ◽  
...  
Keyword(s):  
Fetal Tissue ◽  
Human Fetal Tissue ◽  
Neuronal Precursors ◽  
Identification And Characterization

The synthetic ceramide analog l-PDMP partially protects striatal dopamine levels but does not promote dopamine neuron survival in murine models of parkinsonism

2006 ◽  
Vol 1099 (1) ◽  
pp. 199-205 ◽  
Author(s):  
J.S. Schneider ◽  
K.A. Bradbury ◽  
Yoshihiro Anada ◽  
Jin-ichi Inokuchi ◽  
D.W. Anderson
Keyword(s):  
Dopamine Neuron ◽  
Striatal Dopamine ◽  
Murine Models ◽  
Neuron Survival
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