Reversible splenial lesion syndrome in children with benign convulsions associated with mild gastroenteritis: A retrospective study of five cases

2019 ◽  
Vol 41 (3) ◽  
pp. 271-275 ◽  
Author(s):  
Lihua Jiang ◽  
Shanshan Mao ◽  
Jialu Xu ◽  
Feng Gao
Keyword(s):  
Retrospective Study ◽  
Splenial Lesion ◽  
Reversible Splenial Lesion Syndrome

Reversible splenial lesion syndrome in children: Retrospective study and summary of case series

2016 ◽  
Vol 38 (10) ◽  
pp. 915-927 ◽  
Author(s):  
Wen-Xiong Chen ◽  
Hong-Sheng Liu ◽  
Si-Da Yang ◽  
Si-Hui Zeng ◽  
Yuan-Yuan Gao ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Case Series ◽  
Splenial Lesion ◽  
Reversible Splenial Lesion Syndrome

scholarly journals Reversible splenial lesion syndrome (RESLES) due to acute intermittent porphyria with a novel mutation in the hydroxymethylbilane synthase gene

2020 ◽  
Author(s):  
xiaoqing li ◽  
fei han ◽  
qianlong chen ◽  
tienan zhu ◽  
yongqiang zhao ◽  
...  
Keyword(s):  
Biosynthetic Pathway ◽  
Autosomal Dominant ◽  
Stop Codon ◽  
Novel Mutation ◽  
Acute Intermittent Porphyria ◽  
Porphobilinogen Deaminase ◽  
Autosomal Dominant Disorder ◽  
Splenial Lesion ◽  
Partial Deficiency ◽  
Reversible Splenial Lesion Syndrome

Abstract Background: Reversible splenial lesion syndrome (RESLES) is a clinico-radiological syndrome characterized by the presence of reversible lesions specifically involving the splenium of the corpus callosum (SCC). The cause of RESLES is unknown. However, infectious-related mild encephalitis/encephalopathy (MERS) with a reversible splenial lesion remains the most common cause of reversible splenial lesions. Acute intermittent porphyria (AIP) is an autosomal dominant disorder caused by a partial deficiency of porphobilinogen deaminase (PBGD), the third enzyme in the heme biosynthetic pathway. It can affect the autonomic, peripheral, and central nervous system. Result: In this study, we report a 20-year-old woman with AIP who presented with MRI manifestations suggestive of RESLES, she had a novel HMBS nonsense mutation, a G to A mutation in base 594, which changed tryptophan to a stop codon (W198*). Conclusion: To the best of our knowledge, this is only one published case of RELES associated with AIP.

Mild Encephalitis/Encephalopathy with reversible splenial lesion syndrome: An unusual presentation of anti-GFAP astrocytopathy

2020 ◽  
Vol 26 ◽  
pp. 89-91 ◽  
Author(s):  
Valentin Oger ◽  
Chloé Bost ◽  
Lucie Salah ◽  
Elise Yazbeck ◽  
Hélène Maurey ◽  
...  
Keyword(s):  
Unusual Presentation ◽  
Splenial Lesion ◽  
Reversible Splenial Lesion Syndrome

scholarly journals Reversible splenial lesion syndrome due to oxcarbazepine withdrawal: case report and literature review

2018 ◽  
Vol 46 (3) ◽  
pp. 1277-1281 ◽  
Author(s):  
Chaoyang Jing ◽  
Lichao Sun ◽  
Zhuo Wang ◽  
Chaojia Chu ◽  
Weihong Lin
Keyword(s):  
Case Report ◽  
Corpus Callosum ◽  
Epileptic Seizures ◽  
Resonance Imaging ◽  
Splenial Lesion ◽  
History Of ◽  
Reversible Lesion ◽  
Magnetic Resonance Imaging Mri ◽  
Reversible Splenial Lesion Syndrome

Background Reversible splenial lesion syndrome is a distinct entity radiologically characterized by a reversible lesion in the splenium of the corpus callosum. According to previous reports, this condition may be associated with antiepileptic drug use or withdrawal. We herein report a case of reversible splenial lesion syndrome associated with oxcarbazepine withdrawal. Case Report A 39-year-old man presented with an 8-year history of epileptic seizures. During the previous 3 years, he had taken oxcarbazepine irregularly. One week prior to admission, he withdrew the oxcarbazepine on his own, and the epilepsy became aggravated. Magnetic resonance imaging (MRI) revealed an isolated lesion in the splenium of the corpus callosum with slight hypointensity on T1-weighted imaging and slight hyperintensity on T2-weighted imaging. Regular oxcarbazepine was prescribed. Over a 5-month follow-up period, repeat MRI showed that the abnormal signals in the splenium of the corpus callosum had completely disappeared. Conclusion Reversible splenial lesion syndrome is a rare clinicoradiological disorder that can resolve spontaneously with a favorable outcome. Clinicians should be aware of this condition and that oxcarbazepine withdrawal is a possible etiological factor.

Reversible splenial lesion syndrome in cerebral malaria

2010 ◽  
Vol 37 (4) ◽  
pp. 243-246 ◽  
Author(s):  
P. Hantson ◽  
D. Hernalsteen ◽  
G. Cosnard
Keyword(s):  
Cerebral Malaria ◽  
Splenial Lesion ◽  
Reversible Splenial Lesion Syndrome

scholarly journals Reversible Splenial Lesion Syndrome with Mental Disorders as Only Manifestation

2021 ◽  
Author(s):  
Ziyun Xu ◽  
Zhaoguang Zhou ◽  
Wentao Jang ◽  
Jianhong Tian ◽  
Gangqiang Hou
Keyword(s):  
Mental Disorders ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Somatoform Disorder ◽  
Mri Findings ◽  
Splenial Lesion ◽  
Diffusion Weighted Images ◽  
Conversion Disorders ◽  
Fluid Attenuated Inversion Recovery ◽  
Reversible Splenial Lesion Syndrome

Abstract Background Reversible splenial lesion syndrome (RESLES) was reported to be associated with variable entities. However, much less is known about the cases in which the mental disorders act as the only manifestation. Method: Total ten patients of RESLES were obtained in this retrospective study from Shenzhen Kangning Hospital. T1-fluid attenuated inversion recovery (T1-FLAIR), T2-weighted images, T2-FLAIR, diffusion-weighted images and apparent diffusion coefficient map were performed on all the patients. Clinical manifestations, laboratory examination results, magnetic resonance imaging (MRI) findings, treatments and outcomes were analyzed. Result All patients showed different mental disorders as the only manifestation. There were two cases of alcohol abuse, one of Asperger’s syndrome with malnutrition, one of infection and one of invasive pituitary adenoma. The other cases were diagnosis as major depressive disorder, dissociative and conversion disorders, undifferentiated somatoform disorder, unspecified psychosis and bipolar disorder, respectively. Three patients were completely recovered while the clinical symptoms of rest seven patients partially recovered at the follow-up three months later. Oval-shaped lesion centered on the splenial of corpus callosum (SCC) was observed in all patients using MRI. The lesions of SCC of all patients were completely resolved within five weeks. Conclusion MRI is an essential tool to identify the RESLES. For the patients with acute mental disorders, clinicians should be alert to the possibility of RESLES. Excluding other possible etiologies, we suggest that different mental disorders might be precipitating factors of RESLES.

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