Reversible splenial lesion syndrome in children: Retrospective study and summary of case series

2016 ◽  
Vol 38 (10) ◽  
pp. 915-927 ◽  
Author(s):  
Wen-Xiong Chen ◽  
Hong-Sheng Liu ◽  
Si-Da Yang ◽  
Si-Hui Zeng ◽  
Yuan-Yuan Gao ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Case Series ◽  
Splenial Lesion ◽  
Reversible Splenial Lesion Syndrome

Clinical and Magnetic Resonance Imaging Features of Reversible Splenial Lesion Syndrome in Adults: A Small Case Series

2019 ◽  
Vol 82 (4-6) ◽  
pp. 86-92
Author(s):  
Wen Xu ◽  
Yan Zhou ◽  
Yan Jiang ◽  
Li Zhang ◽  
Qiqiang Tang
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Thyroid Dysfunction ◽  
Case Series ◽  
Cell Number ◽  
Imaging Features ◽  
Resonance Imaging ◽  
Splenial Lesion ◽  
Mri Features ◽  
Reversible Splenial Lesion Syndrome

Background: To study clinical and magnetic resonance imaging (MRI) features of reversible splenial lesion syndrome (RESLES) in adult patients. Methods: A retrospective analysis was performed using clinical, cerebrospinal fluid (CSF), laboratory results, and neuroimaging data obtained from 6 adult RESLES patients. Results: All 6 patients (3 male cases, 3 female cases) were determined to be acute or subacute onset, most of them associated with infection or fever. All initial MRI data exhibited splenium of corpus callosum lesions with hypointensity on T1WI, hyperintensity on T2WI, diffusion-weighted imaging (DWI) and Flair, without significant gadolinium enhancement. Five patients were treated with glucocorticoids and showed significant improvement in 1–15 days, with the lesion having disappeared or weakened, and one case was lost of follow-up. The cell number and protein amount in CSF were determined to be at normal levels, or slightly increased in 3 patients with thyroid dysfunction. Conclusion: The etiology of adult RESLES was observed to be complex and diverse, primarily related to infection, fever, and thyroid dysfunction. DWI was found to be more sensitive in these lesions, and CSF cytology was observed to be either normal or mildly abnormal. A majority of patients were found to be sensitive to glucocorticoid, and have a good prognosis with lesions that disappeared rapidly.

scholarly journals Reversible splenial lesion syndrome in children: clinical analysis and summary of a case series

2020 ◽  
Vol 48 (4) ◽  
pp. 030006052091420
Author(s):  
Xinying Zhang ◽  
Na Chen ◽  
Jiamin Guo ◽  
Shuwei Li ◽  
Jiaming Xu ◽  
...  
Keyword(s):  
Case Series ◽  
Clinical Analysis ◽  
Splenial Lesion ◽  
Reversible Splenial Lesion Syndrome

scholarly journals ALTERNATIVE TO THE INVERTED “Y” INCISION IN SCOLIOSIS SECONDARY TO MYELOMENINGOCELE

2019 ◽  
Vol 18 (1) ◽  
pp. 14-16
Author(s):  
Diego Veiga Bezerra ◽  
Luis Eduardo Munhoz da Rocha ◽  
Dulce Helena Grimm ◽  
Carlos Abreu de Aguiar ◽  
Luiz Müller Ávila ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Spina Bifida ◽  
Postoperative Period ◽  
Medical Records ◽  
Surgical Intervention ◽  
Case Series ◽  
Material Failure ◽  
Spinal Deformities ◽  
Level Of Evidence ◽  
Skin Conditions

ABSTRACT Objective: To evaluate the healing of the modified inverted “Y” incision in patients with scoliosis due to myelomeningocele. Methods: Retrospective study through medical records review of patients with myelomeningocele surgically treated with a modified inverted “Y” approach between January 2013 and December 2015. Results: We analyzed the medical records of six patients. Two patients progressed with skin complications in the immediate postoperative period and only one of them required surgical intervention for debridement and suturing. In another patient, it was necessary to perform two surgical reviews due to material failure without skin complications in these interventions. Conclusions: The modified inverted “Y” technique is a great alternative to traditional incision and inverted “Y” because it has good results in patients with spina bifida associated with poor skin conditions treated surgically for correction of spinal deformities. Level of Evidence IV; Case series.

scholarly journals Reversible splenial lesion syndrome (RESLES) due to acute intermittent porphyria with a novel mutation in the hydroxymethylbilane synthase gene

2020 ◽  
Author(s):  
xiaoqing li ◽  
fei han ◽  
qianlong chen ◽  
tienan zhu ◽  
yongqiang zhao ◽  
...  
Keyword(s):  
Biosynthetic Pathway ◽  
Autosomal Dominant ◽  
Stop Codon ◽  
Novel Mutation ◽  
Acute Intermittent Porphyria ◽  
Porphobilinogen Deaminase ◽  
Autosomal Dominant Disorder ◽  
Splenial Lesion ◽  
Partial Deficiency ◽  
Reversible Splenial Lesion Syndrome

Abstract Background: Reversible splenial lesion syndrome (RESLES) is a clinico-radiological syndrome characterized by the presence of reversible lesions specifically involving the splenium of the corpus callosum (SCC). The cause of RESLES is unknown. However, infectious-related mild encephalitis/encephalopathy (MERS) with a reversible splenial lesion remains the most common cause of reversible splenial lesions. Acute intermittent porphyria (AIP) is an autosomal dominant disorder caused by a partial deficiency of porphobilinogen deaminase (PBGD), the third enzyme in the heme biosynthetic pathway. It can affect the autonomic, peripheral, and central nervous system. Result: In this study, we report a 20-year-old woman with AIP who presented with MRI manifestations suggestive of RESLES, she had a novel HMBS nonsense mutation, a G to A mutation in base 594, which changed tryptophan to a stop codon (W198*). Conclusion: To the best of our knowledge, this is only one published case of RELES associated with AIP.

scholarly journals Our comprehensive experience with tracheostomy in tertiary multi-speciality hospital over four years

2021 ◽  
Vol 7 (10) ◽  
pp. 1649
Author(s):  
Parth B. Kapadia ◽  
Manit M. Mandal ◽  
Ajay J. Panchal ◽  
Rakesh Kumar ◽  
Neel Parmar ◽  
...  
Keyword(s):  
Medical Education ◽  
Retrospective Study ◽  
Surgical Procedure ◽  
Case Series ◽  
Final Outcome ◽  
Patient Age ◽  
Significant Case ◽  
Surgical Emphysema ◽  
The Mean ◽  
Mean Time

<p class="abstract"><strong>Background:</strong> Tracheostomy is a common surgical procedure used to achieve a secure airway in patients in elective as well as emergency conditions. Our study accounts for our first-hand experience with the procedure in our tertiary multi-speciality hospital.</p><p class="abstract"><strong>Methods:</strong> It is a four year (January 2017 to February 2021) retrospective study in which all the 246 cases of tracheostomies were taken into account which were performed during this study period in the department of otorhinolaryngology (ENT), Surat Municipal Institute of Medical Education and Research (SMIMER), Surat (India). The patients were thoroughly followed up until the final outcome of the tracheostomy was established.  </p><p class="abstract"><strong>Results:</strong> A total of 246 tracheostomies were performed, 63.82% of which were in men. The mean patient age was 42 years. The majority (76%) were elective, performed for various indications, while the remaining 24% were emergency tracheostomies. All tracheostomies were performed by otorhinolaryngologists. Complications relating to tracheostomy were documented in 40 patients (16%) intra-operatively and/or post-operatively which included bleeding, surgical emphysema, granulations along the stomal site and rarely shock. The mean time to decannulation was 13.48 days.</p><p class="abstract"><strong>Conclusions:</strong> Our study takes into account and discusses the findings of all the 246 tracheostomies which were performed during the study period of 4 years. Elective cases form the majority although there is a significant case series of emergency tracheostomies performed for a range of pathologies.</p><p class="Default"> </p>

Mild Encephalitis/Encephalopathy with a Reversible Isolated Splenial Lesion (MERS) in Adult Patients: A Small Case Series

2020 ◽  
Vol 83 (3) ◽  
pp. 279-286
Author(s):  
Zhen Zhang ◽  
Jing Guo ◽  
Xiaobin Li ◽  
Chuanling Li ◽  
Xiaolin Ma ◽  
...  
Keyword(s):  
Elevated Serum ◽  
Case Series ◽  
Cell Number ◽  
Point Of View ◽  
Chinese Patients ◽  
Cell Content ◽  
Splenial Lesion ◽  
Eeg Data ◽  
Adc Values ◽  
Magnetic Resonance Imaging Mri

Background: Mild encephalitis/encephalopathy with a reversible isolated splenial lesion (MERS) is a rare and complex clinico-radiological condition that aggregates various diseases. From a geographical point of view, most cases have been reported in Asia, especially in Japan. However, a very limited number of studies have properly evaluated Chinese patients diagnosed with MERS. Methods: Putative encephalitis/encephalopathy patients affected by a reversible isolated SCC lesion, as detected by magnetic resonance imaging (MRI), were retrospectively evaluated. Specifically, we reviewed extensive patient data, including prodromal and neurologic symptoms, neurologic examinations, MRI and electroencephalography (EEG) findings, laboratory results, treatments, and prognosis. Results: Six clinically mild encephalitis/encephalopathy patients, affected by a reversible isolated SCC lesion, were identified in a cohort of 22 patients. Six patients presented fever symptoms before the onset of neurological manifestations. Initial MRI data exhibited isolated SCC lesions with isointense or slightly hypointense on T1WI, hyperintense on T2WI, Flair, and DWI, as well as decreased ADC values, without contrast enhancement. EEG data indicated abnormalities (3/4), as well as elevated serum inflammatory markers (5/6) and hyponatremia (4/6). Cell content and protein yields were normal or slightly increased in the CSF of 6 patients, excluding one episode of significant increase in cell number. Patients were treated with corticosteroids, antivirals, and antibiotics, resulting in their full clinical recovery. SCC lesions mostly disappeared in all patients. Conclusion: In our study, the clinical features identified in all affected patients were mostly identical, which consisted of relatively mild CNS manifestations with a promising prognostic status.

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