scholarly journals In vivo estimates of axonal stretch and 3D brain deformation during mild head impact

2020 ◽  
Vol 1 ◽  
pp. 100015 ◽  
Author(s):  
Andrew K Knutsen ◽  
Arnold D. Gomez ◽  
Mihika Gangolli ◽  
Wen-Tung Wang ◽  
Deva Chan ◽  
...  
Keyword(s):  
Head Impact ◽  
Brain Deformation

Atlas of Acceleration-Induced Brain Deformation from Measurements In Vivo

2018 ◽  
pp. 3-14
Author(s):  
Arnold D. Gomez ◽  
Andrew Knutsen ◽  
Deva Chan ◽  
Yuan-Chiao Lu ◽  
Dzung L. Pham ◽  
...  
Keyword(s):  
Brain Deformation

Laboratory assessment of a head impact sensor for youth soccer ball heading impacts using an anthropomorphic test device

2021 ◽  
pp. 175433712110631
Author(s):  
Declan A Patton ◽  
Colin M Huber ◽  
Ethan C Douglas ◽  
Thomas Seacrist ◽  
Kristy B Arbogast
Keyword(s):  
Angular Velocity ◽  
Human Subjects ◽  
Linear Acceleration ◽  
Head Impact ◽  
Percentage Error ◽  
Test Device ◽  
Laboratory Assessment ◽  
Soccer Ball ◽  
Youth Soccer

Recent advances in technology have enabled the development of instrumented equipment, which estimate the head impact kinematics of athletes in vivo. One such headband-mounted impact sensor is the SIM-G (Triax Technologies, Norwalk, CT, USA), which has been previously used to investigate the biomechanics of soccer heading by human subjects. Previous studies have evaluated the accuracy of the SIM-G for pure rotation and pendulum, impulse hammer and drop rig impacts. The current study used a soccer ball heading model to evaluate the accuracy of the SIM-G. A soccer ball was projected at the head of an anthropomorphic test device (ATD) representing a 10-year-old to replicate the heading maneuver at various impact sites, angles and speeds previously identified in youth soccer. Linear regression revealed that the SIM-G sensor overestimated the peak angular velocity and linear acceleration recorded by the ATD headform by approximately 44% and 105%, respectively. Tests in which the ball directly contacted the SIM-G sensor resulted in the largest peak linear accelerations. Glancing impacts were significantly associated with a decrease in percentage error of the SIM-G sensor peak angular velocity data relative to the ATD reference data. While it may not demonstrate accuracy in estimating the magnitudes of head impacts, the SIM-G remains a useful tool to provide estimates of head impact exposure for soccer players.

Comparing In Vivo Head Impact Kinematics From American Football With Laboratory Drop and Linear Impactors

2013 ◽  
Author(s):  
Fidel Hernandez ◽  
Pete B. Shull ◽  
Bruce Cam ◽  
Lyndia Wu ◽  
Rebecca Shultz ◽  
...  
Keyword(s):  
High School ◽  
Brain Function ◽  
Laboratory Testing ◽  
Laboratory Tests ◽  
Head Impact ◽  
American Football ◽  
Football Players ◽  
Test Apparatus ◽  
Kinematic Measures

Roughly 5% of all collegiate and high school American football players suffer a concussion each season [1]. Concussions and repetitive sub-concussive trauma can have measurable effects on brain function and neurophysiological changes [2]. Several studies have suggested that a combination of linear and angular kinematic measures may be predictive of concussion [3, 4]. Presently, laboratory testing and analysis of purely linear kinematics is used to design and assess the safety of protective headgear. However, it is not known how well existing laboratory tests recapitulate angular kinematics. In this study, we analyze combinations of linear and angular head kinematics experienced by players on the field. This study sought to answer the question: how well do the twin-wire drop test apparatus and a spring-driven linear impactor reproduce the combination of linear and angular head impact kinematics experienced in vivo by players of American football?

Brain structure alterations and cognitive impairment following repetitive mild head impact: An in vivo MRI and behavioral study in rat

2018 ◽  
Vol 340 ◽  
pp. 41-48 ◽  
Author(s):  
Yang Qin ◽  
Gai-Li Li ◽  
Xian-Hua Xu ◽  
Zhi-Yong Sun ◽  
Jian-Wen Gu ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Brain Structure ◽  
Head Impact ◽  
Behavioral Study

An in-vivo model of functional head impact testing in non-helmeted athletes

2009 ◽  
Vol 223 (3) ◽  
pp. 117-123 ◽  
Author(s):  
M J Higgins ◽  
R T Tierney ◽  
S Caswell ◽  
J B Driban ◽  
J Mansell ◽  
...  
Keyword(s):  
Functional Activity ◽  
Repeated Measures ◽  
Human Head ◽  
Head Impact ◽  
Impact Testing ◽  
In Vivo Model ◽  
Testing Model ◽  
Repeated Measures Design ◽  
Soccer Heading

Development of a functional in-vivo head impact testing model would enhance the ability to elucidate mechanisms underlying individual responses to head impact in sports where a helmet is not worn. The objective of this paper is to describe a novel in-vivo method of assessing human head linear impact acceleration during the functional activity of soccer heading, using a repeated-measures design in a university research laboratory. 17 college-aged soccer players (age, 20.93 years (standard deviation (SD), 1.17 years); height, 170.39cm (SD, 10.15cm); mass, 71.50kg (SD, 9.89kg); head—neck mass, 5.90kg (SD, 0.83kg)) participated in this study. All participants read and signed a university Institutional-Review-Board-approved informed consent before participating. The resultant linear head acceleration (in units of g) was measured for each participant during soccer heading. The head impact model consisted of controlled soccer headers and a triaxial accelerometer affixed to a custom-fitted mouthpiece. A force-sensitive resistor on the forehead assessed impact quality. Standard soccer balls were projected from a JUGS soccer machine travelling at 11.10m/s (25mile/h) and covering a distance of 11m (35ft). The subjects performed standing or simulated headers while aiming at a target positioned 5m in front of them. The intra-class correlation coefficient (ICC2,1) was 0.845 for resultant accelerations. In this paper, the development and testing of a novel in-vivo functional human head impact testing model are described. Results suggest that this methodology has potential for assessing resultant peak linear head impact accelerations during the functional activity of soccer heading and in other non-helmet-wearing sports.

scholarly journals In Vivo Evaluation of Wearable Head Impact Sensors

2015 ◽  
Vol 44 (4) ◽  
pp. 1234-1245 ◽  
Author(s):  
Lyndia C. Wu ◽  
Vaibhav Nangia ◽  
Kevin Bui ◽  
Bradley Hammoor ◽  
Mehmet Kurt ◽  
...  
Keyword(s):  
Head Impact ◽  
In Vivo Evaluation

In vivo quantification of a homogeneous brain deformation model for updating preoperative images during surgery

2000 ◽  
Vol 47 (2) ◽  
pp. 266-273 ◽  
Author(s):  
M.I. Miga ◽  
K.D. Paulsen ◽  
P.J. Hoopes ◽  
F.E. Kennedy ◽  
A. Hartov ◽  
...  
Keyword(s):  
Deformation Model ◽  
Brain Deformation

In Vivo Analysis of Heterogeneous Brain Deformation Computations for Model-Updated Image Guidance

2000 ◽  
Vol 3 (2) ◽  
pp. 129-146 ◽  
Author(s):  
MICHAEL I. MIGA ◽  
KEITH D. PAULSEN ◽  
FRANCIS E. KENNEDY ◽  
P. JACK HOOPES ◽  
ALEX HARTOV ◽  
...  
Keyword(s):  
Image Guidance ◽  
Brain Deformation ◽  
In Vivo Analysis

scholarly journals Statistical Characterization of Human Brain Deformation During Mild Angular Acceleration Measured In Vivo by Tagged Magnetic Resonance Imaging

2018 ◽  
Vol 140 (10) ◽  
Author(s):  
Deva D. Chan ◽  
Andrew K. Knutsen ◽  
Yuan-Chiao Lu ◽  
Sarah H. Yang ◽  
Elizabeth Magrath ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Gray Matter ◽  
Tissue Type ◽  
Resonance Imaging ◽  
Brain Deformation ◽  
Cortical Gray Matter ◽  
Tagged Magnetic Resonance Imaging ◽  
The Brain

Understanding of in vivo brain biomechanical behavior is critical in the study of traumatic brain injury (TBI) mechanisms and prevention. Using tagged magnetic resonance imaging, we measured spatiotemporal brain deformations in 34 healthy human volunteers under mild angular accelerations of the head. Two-dimensional (2D) Lagrangian strains were examined throughout the brain in each subject. Strain metrics peaked shortly after contact with a padded stop, corresponding to the inertial response of the brain after head deceleration. Maximum shear strain of at least 3% was experienced at peak deformation by an area fraction (median±standard error) of 23.5±1.8% of cortical gray matter, 15.9±1.4% of white matter, and 4.0±1.5% of deep gray matter. Cortical gray matter strains were greater in the temporal cortex on the side of the initial contact with the padded stop and also in the contralateral temporal, frontal, and parietal cortex. These tissue-level deformations from a population of healthy volunteers provide the first in vivo measurements of full-volume brain deformation in response to known kinematics. Although strains differed in different tissue type and cortical lobes, no significant differences between male and female head accelerations or strain metrics were found. These cumulative results highlight important kinematic features of the brain's mechanical response and can be used to facilitate the evaluation of computational simulations of TBI.

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