scholarly journals Artificial Pneumothorax in CT-Guided Radioactive Iodine-125 Seed Implantation in the Treatment of Mediastinal Tumors

Brachytherapy ◽  
2016 ◽  
Vol 15 ◽  
pp. S150
Author(s):  
Ni Ronghui
Keyword(s):  
Radioactive Iodine ◽  
Mediastinal Tumors ◽  
Ct Guided ◽  
Seed Implantation ◽  
Artificial Pneumothorax ◽  
Iodine 125

scholarly journals Puncture and Dose Accuracies of Navigation-Assisted 3D-Printing Templates Combined with Computed Tomography Guided Radioactive Iodine-125 Seed Implantation in the Treatment of Malignant Tumors

2020 ◽  
Author(s):  
Zhe Ji ◽  
Yuliang Jiang ◽  
Haitao Sun ◽  
Fuxin Guo ◽  
Jinghong Fan ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Radioactive Iodine ◽  
Malignant Tumors ◽  
Insertion Point ◽  
Seed Implantation ◽  
Significant Difference ◽  
Tip Position ◽  
Iodine 125 ◽  
Preoperative Plan ◽  
Nonparametric Correlation

Abstract Objective: To preliminarily verify the accuracy of navigation-assisted seed implantation by comparing preoperative and actual differences in puncture characteristics and dosimetry in computed tomography-guided, navigation-assisted radioactive iodine-125 seed implantation using 3D-printed templates for the treatment of malignant tumors. Methods: A total of 27 tumor patients who were treated with seed implantation under combination guidance in our hospital between December 2018 to December 2019 were enrolled in this study. Navigation needles (n=1–3) were placed in each patient to obtain preoperative and intraoperative puncture information, including angle, depth, insertion point, and tip position; we also investigated the dosimetry parameters in the preoperative and postoperative plans, including D90, V100, V150, V200, minimum peripheral dose (MPD), conformal index, external index, and homogeneity index of the target area. The t-tests and nonparametric correlation tests were used for analysis (P<0.05 was considered significant). Results: The means errors of the angle, depth, insertion point, and tip position were 0.47 ± 0.521°, 0.35 ± 0.238 cm, 1.7 ± 0.99 mm, and 3.1 ± 1.75 mm, respectively. There were no significant differences between the intraoperative and preoperative angles (P = 0.271), but there was a significant difference in depth (P = 0.002). Errors of the angle, depth, and insertion point were larger for the pelvic/retroperitoneal area than for the head and neck/chest wall (P < 0.05). With the exception of MPD, there was no significant difference in dosimetry indices between the postoperative and preoperative plans (P > 0.05). The MPD in the postoperative plan was higher than that in the preoperative plan (mean: 72.1 Gy and 63.8 Gy, respectively; P < 0.05). Conclusion: Seed implantation under combination guidance showed good accuracy, and the actual intraoperative puncture information and postoperative doses were in good agreement with those in the preoperative plan, thereby demonstrating promising prospects for further development.

scholarly journals The accuracy and safety of CT-guided iodine-125 seed implantation assisted by 3D non-coplanar template for retroperitoneal recurrent carcinoma

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Weijuan Jiang ◽  
Ping Jiang ◽  
Shuhua Wei ◽  
Yuliang Jiang ◽  
Zhe Ji ◽  
...  
Keyword(s):  
Real Time ◽  
Planning System ◽  
Ct Guided ◽  
Seed Implantation ◽  
The Mean ◽  
Iodine 125 ◽  
Preoperative Plan ◽  
Distance Deviation ◽  
Time Plan

Abstract Purpose To investigate the accuracy, dosimetric parameters, and safety of 3D-printing non-coplanar template (3D-PNCT)-assisted CT guidance for radioactive iodine-125 (125I) seed implantation brachytherapy (RSI-BT) for retroperitoneal recurrent carcinomas Methods and materials We enrolled 15 patients with 17 retroperitoneal recurrent carcinomas after external beam radiotherapy (EBRT). All patients received CT-guided 125I RSI-BT assisted by 3D-PNCT successfully. We compared the original needle insertion position, angular, and the needle tip distance deviations of preoperative plan with that of intraoperative in brachytherapy treatment planning system (B-TPS). The dosimetric parameters of RSI-BT were evaluated on preoperative plan, intraoperative real-time plan, and postoperative plan, including D90, D100 (the dose to 90% and 100% of the target volume), V100, V150, and V200 (the volume receives 100%, 150%, and 200% of the prescribed doses). The quality assurance of RSI-BT evaluated on conformal index (CI), external index (EI), and homogeneity index (HI) of the targets were compared among preoperative plan, intraoperative real-time plan, and postoperative plan. The perioperation complications and RSI-BT-related toxicity were assessed. Results The median follow-up was 8.2 months (range 1–18.5 months). One patient was lost to follow-up after RSI-BT. Fourteen patients were assessed for response rate and toxicity. The mean entrance point distance deviation for all 165 needles was 4.50 ± 4.10 mm (range, 0–30). The mean angular deviation was 2.70 ± 3.00° (range, 0–20). The needle tip distance deviation was 6.90 ± 6.00 mm (range, − 30–28). D90 for preoperative plan, intraoperative plan, and postoperative plan were 140.55 ± 23.93, 124.25 ± 28.04, and 128.98 ± 22.75, respectively. There was significant difference between D90 of preoperative plan with that of intraoperative plan (p = 0.036). Four lesions reached CR, six lesions reached PR, three lesions were SD, and three lesions were PD. Four patients with moderate pain became mild, and two with mild pain relieved completely after RSI-BT. The other parameters showed no differences among preoperative plan, intraoperative plan, and postoperative plan. The perioperative complications were observed in four patients, including three patients of grade 1 and one patient of grade 2. No ≥ grade 3 side effects were observed. Conclusion CT-guided 125I RSI-BT assisted by 3D-PNCT was a safe, accurate, and feasible strategy for recurrent carcinomas located in the retroperitoneal regions.

scholarly journals Locally advanced pancreatic carcinoma with jaundice: the benefit of a sequential treatment with stenting followed by CT-guided 125I seeds implantation

2021 ◽  
Author(s):  
Chao Chen ◽  
Wei Wang ◽  
Wujie Wang ◽  
Yongzheng Wang ◽  
Zhe Yu ◽  
...  
Keyword(s):  
Treatment Group ◽  
Obstructive Jaundice ◽  
Pancreatic Carcinoma ◽  
Locally Advanced ◽  
Biliary Stenting ◽  
Ct Guided ◽  
Seed Implantation ◽  
Locally Advanced Pancreatic Carcinoma ◽  
Advanced Pancreatic Carcinoma ◽  
Iodine 125

Abstract Objectives To evaluate the role of sequential therapy with percutaneous biliary stenting and CT-guided iodine-125 seed implantation for locally advanced pancreatic carcinoma with concomitant obstructive jaundice. Methods Between January 2016 and December 2018, 42 patients diagnosed with locally advanced pancreatic carcinoma with concomitant obstructive jaundice were enrolled retrospectively. All patients received biliary stenting via percutaneous transhepatic biliary drainage (PTBD) to alleviate obstructive jaundice. Thereafter, twenty-two patients underwent CT-guided iodine-125 seed implantation (treatment group), and 20 did not (control group). The prescribed dose in the treatment group was 110–130 Gy. The clinical data, duration of biliary stent patency, and overall survival (OS) were evaluated. Results Overall, the total bilirubin level decreased from 275.89 ± 115.44 to 43.08 ± 43.35 μmol/L (p < 0.001) 1 month after percutaneous biliary stenting. In the treatment group, the postoperative median dose covering 90% of the target volume was 129.71 Gy. Compared with the control group, the treatment group had a long mean duration of biliary stent patency and median OS (11.42 vs. 8.57 months, p < 0.01; 11.67 vs. 9.40 months, p < 0.01, respectively). The overall positive response rates 6 months post-treatment in the treatment and control groups were 72.7% (16/22) and 30% (6/20), respectively. Adverse events of more than grade 3 were not observed during the follow-up. Conclusion Sequential therapy with percutaneous biliary stenting and CT-guided iodine-125 seed implantation is an effective and safe treatment alternative for locally advanced pancreatic carcinoma with concomitant obstructive jaundice, which is worthy of clinical application. Key Points • Obstructive jaundice was alleviated after biliary stent placement in all patients, and the total bilirubin level decreased. • The overall positive response rates at 6 months post-treatment were higher in the treatment group than in the control group, and adverse events of more than grade 3 were not observed during the follow-up period. • Sequential therapy with percutaneous biliary stenting and CT-guided iodine-125 seed implantation can prolong biliary stent patency and improve survival.

OC-75 CT-GUIDED INTERSTITIAL IODINE-125 SEED IMPLANTATION IN THE TREATMENT OF SPINAL AND PARASPINAL MALIGNANCIES

2012 ◽  
Vol 103 ◽  
pp. S30
Author(s):  
C. Liu ◽  
H.S. Yuan ◽  
J.J. Wang ◽  
N. Meng ◽  
Y.Q. Ma ◽  
...  
Keyword(s):  
Ct Guided ◽  
Seed Implantation ◽  
Iodine 125
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