scholarly journals Multistep Folding Kinetics of Group I Intron RNA Studied by Mg 2+ -Concentration Jump Simulations

2017 ◽  
Vol 112 (3) ◽  
pp. 370a
Author(s):  
Naoto Hori ◽  
Natalia A. Denesyuk ◽  
D Thirumalai
Genes ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 347
Author(s):  
Jiabin Huang ◽  
Björn Voß

Studying the folding kinetics of an RNA can provide insight into its function and is thus a valuable method for RNA analyses. Computational approaches to the simulation of folding kinetics suffer from the exponentially large folding space that needs to be evaluated. Here, we present a new approach that combines structure abstraction with evolutionary conservation to restrict the analysis to common parts of folding spaces of related RNAs. The resulting algorithm can recapitulate the folding kinetics known for single RNAs and is able to analyse even long RNAs in reasonable time. Our program RNAliHiKinetics is the first algorithm for the simulation of consensus folding kinetics and addresses a long-standing problem in a new and unique way.


1993 ◽  
Vol 21 (2) ◽  
pp. 311-317 ◽  
Author(s):  
Barbara Striecjer ◽  
Uwe von Ahsen ◽  
Renée Schroeder

2012 ◽  
Vol 103 (7) ◽  
pp. 1555-1565 ◽  
Author(s):  
Tzachi Hagai ◽  
Ariel Azia ◽  
Emmanuel Trizac ◽  
Yaakov Levy

1999 ◽  
Vol 35 (5) ◽  
pp. 536-541 ◽  
Author(s):  
M. Grube ◽  
B. Gutmann ◽  
U. Arup ◽  
A. de los Rios ◽  
J.-E. Mattsson ◽  
...  

1992 ◽  
Vol 6 (8) ◽  
pp. 1373-1385 ◽  
Author(s):  
F Michel ◽  
L Jaeger ◽  
E Westhof ◽  
R Kuras ◽  
F Tihy ◽  
...  

Biochemistry ◽  
2006 ◽  
Vol 45 (35) ◽  
pp. 10504-10511 ◽  
Author(s):  
Jasmin Faraone-Mennella ◽  
F. Akif Tezcan ◽  
Harry B. Gray ◽  
Jay R. Winkler
Keyword(s):  

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