Amino-functionalized single-chain bolalipids: Synthesis and aggregation behavior of new basic building blocks

2010 ◽  
Vol 150 (1-3) ◽  
pp. 136-143 ◽  
Author(s):  
Simon Drescher ◽  
Gesche Graf ◽  
Gerd Hause ◽  
Bodo Dobner ◽  
Annette Meister
Keyword(s):  
Building Blocks ◽  
Aggregation Behavior ◽  
Single Chain

scholarly journals Smaller Building Blocks Form Larger Assemblies:  Aggregation Behavior of Biaryl-Based Dendritic Facial Amphiphiles

2007 ◽  
Vol 72 (22) ◽  
pp. 8167-8174 ◽  
Author(s):  
Ashootosh V. Ambade ◽  
Sivakumar V. Aathimanikandan ◽  
Derek van der Poll ◽  
S. Thayumanavan
Keyword(s):  
Building Blocks ◽  
Aggregation Behavior

scholarly journals Structural diversity of oligomeric β-propellers with different numbers of identical blades

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Evgenia Afanasieva ◽  
Indronil Chaudhuri ◽  
Jörg Martin ◽  
Eva Hertle ◽  
Astrid Ursinus ◽  
...  
Keyword(s):  
High Resolution ◽  
Building Block ◽  
Polypeptide Chain ◽  
Structural Diversity ◽  
Building Blocks ◽  
Single Chain ◽  
Single Polypeptide Chain ◽  
Data Support ◽  
Single Polypeptide ◽  
Structural Versatility

β-Propellers arise through the amplification of a supersecondary structure element called a blade. This process produces toroids of between four and twelve repeats, which are almost always arranged sequentially in a single polypeptide chain. We found that new propellers evolve continuously by amplification from single blades. We therefore investigated whether such nascent propellers can fold as homo-oligomers before they have been fully amplified within a single chain. One- to six-bladed building blocks derived from two seven-bladed WD40 propellers yielded stable homo-oligomers with six to nine blades, depending on the size of the building block. High-resolution structures for tetramers of two blades, trimers of three blades, and dimers of four and five blades, respectively, show structurally diverse propellers and include a novel fold, highlighting the inherent flexibility of the WD40 blade. Our data support the hypothesis that subdomain-sized fragments can provide structural versatility in the evolution of new proteins.

scholarly journals The Headgroup (A)Symmetry Strongly Determines the Aggregation Behavior of Single-Chain Phenylene-Modified Bolalipids and Their Miscibility with Classical Phospholipids

Langmuir ◽  
2014 ◽  
Vol 30 (31) ◽  
pp. 9273-9284 ◽  
Author(s):  
Simon Drescher ◽  
Bob-Dan Lechner ◽  
Vasil M. Garamus ◽  
László Almásy ◽  
Annette Meister ◽  
...  
Keyword(s):  
Aggregation Behavior ◽  
Single Chain

ChemInform Abstract: Smaller Building Blocks Form Larger Assemblies: Aggregation Behavior of Biaryl-Based Dendritic Facial Amphiphiles.

ChemInform ◽  
2008 ◽  
Vol 39 (5) ◽  
Author(s):  
Ashootosh V. Ambade ◽  
Sivakumar V. Aathimanikandan ◽  
Derek van der Poll ◽  
S. Thayumanavan
Keyword(s):  
Building Blocks ◽  
Aggregation Behavior

Vesicle formation of single-chain amphiphilic 4-dodecylbenzene sulfonic acid in water and micelle-to-vesicle transition induced by wet–dry cycles

Soft Matter ◽  
2021 ◽  
Author(s):  
Meihua Gao ◽  
Na Du ◽  
Zhiyin Yao ◽  
Ying Li ◽  
Nan Chen ◽  
...  
Keyword(s):  
Sulfonic Acid ◽  
Aggregation Behavior ◽  
Vesicle Formation ◽  
Single Chain ◽  
Multilamellar Vesicle ◽  
Dodecylbenzene Sulfonic Acid

Aggregation behavior of DBSA, in water was investigated, showing a concentration-driven micelle-to-vesicle transition. Interestingly, wet–dry cycles can induce micelle-to-vesicle transition and multilamellar vesicle formation.

scholarly journals Crystal structure of full-length cytotoxic necrotizing factor CNFY reveals molecular building blocks for intoxication

2020 ◽  
Author(s):  
Paweena Chaoprasid ◽  
Peer Lukat ◽  
Sabrina Mühlen ◽  
Thomas Heidler ◽  
Emerich-Mihai Gazdag ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Rho Gtpases ◽  
Yersinia Pseudotuberculosis ◽  
Building Blocks ◽  
Full Length ◽  
Host Cells ◽  
Dimensional Structure ◽  
Single Chain ◽  
Sequence Comparisons ◽  
Catalytic Unit

AbstractCytotoxic necrotizing factors (CNFs) are bacterial single-chain exotoxins that modulate cytokinetic/oncogenic and inflammatory processes through activation of host cell Rho GTPases. To achieve this, they are secreted, bind surface receptors to induce endocytosis and translocate a catalytic unit into the cytosol to intoxicate host cells. A three-dimensional structure that provides insight into the underlying mechanisms is still lacking. Here, we determined the crystal structure of full-length Yersinia pseudotuberculosis CNFY. CNFY consists of five domains (D1-D5), and by integrating structural and functional data we demonstrate that D1-3 act as export and translocation module for the catalytic unit (D4-5) or fused β-lactamase reporter proteins. We further found that domain D4, which possesses structural similarity to ADP-ribosyl transferases, but had no equivalent catalytic activity, changed its position to interact extensively with D5 in the crystal structure of the free D4-5 fragment. This liberates D5 from a semi-blocked conformation in full-length CNFY, leading to higher deamidation activity. Finally, sequence comparisons identified the CNF translocation module in many uncharacterized bacterial proteins, suggesting its usability as a universal drug delivery tool.

Valuable structure-size relationships for tadpole-shaped single-chain nanoparticles with long and short flexible tails unveiled

2019 ◽  
Vol 21 (21) ◽  
pp. 10884-10887 ◽  
Author(s):  
Isabel Asenjo-Sanz ◽  
Ester Verde-Sesto ◽  
José A. Pomposo
Keyword(s):  
Polymer Chain ◽  
Building Blocks ◽  
Single Chain ◽  
Flexible Polymer ◽  
Flexible Polymer Chain

Tadpole-shaped single-chain nanoparticles (TSCNPs) are useful soft building blocks for nanotechnology composed of a flexible polymer chain tethered to an intramolecularly folded single-chain nanoparticle.

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