Self-assembly in aqueous solution of a modified amyloid beta peptide fragment

2008 ◽  
Vol 138 (1-2) ◽  
pp. 29-35 ◽  
Author(s):  
V. Castelletto ◽  
I.W. Hamley ◽  
P.J.F. Harris
Keyword(s):  
Aqueous Solution ◽  
Amyloid Beta ◽  
Self Assembly ◽  
Amyloid Beta Peptide ◽  
Peptide Fragment ◽  
Beta Peptide

Influence of the Solvent on the Self-Assembly of a Modified Amyloid Beta Peptide Fragment. I. Morphological Investigation

2009 ◽  
Vol 113 (29) ◽  
pp. 9978-9987 ◽  
Author(s):  
V. Castelletto ◽  
I. W. Hamley ◽  
P. J. F. Harris ◽  
U. Olsson ◽  
N. Spencer
Keyword(s):  
Amyloid Beta ◽  
Self Assembly ◽  
The Self ◽  
Amyloid Beta Peptide ◽  
Peptide Fragment ◽  
Morphological Investigation ◽  
Beta Peptide

Influence of the Solvent on the Self-Assembly of a Modified Amyloid Beta Peptide Fragment. II. NMR and Computer Simulation Investigation

2010 ◽  
Vol 114 (2) ◽  
pp. 940-951 ◽  
Author(s):  
I. W. Hamley ◽  
D. R. Nutt ◽  
G. D. Brown ◽  
J. F. Miravet ◽  
B. Escuder ◽  
...  
Keyword(s):  
Computer Simulation ◽  
Amyloid Beta ◽  
Self Assembly ◽  
The Self ◽  
Amyloid Beta Peptide ◽  
Peptide Fragment ◽  
Beta Peptide

scholarly journals Self-Assembly and Anti-Amyloid Cytotoxicity Activity of Amyloid beta Peptide Derivatives

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
V. Castelletto ◽  
P. Ryumin ◽  
R. Cramer ◽  
I. W. Hamley ◽  
M. Taylor ◽  
...  
Keyword(s):  
Amyloid Beta ◽  
Self Assembly ◽  
Amyloid Beta Peptide ◽  
Cytotoxicity Activity ◽  
Beta Peptide ◽  
Peptide Derivatives

Self-assembly characteristics of a structural analogue of Tjernberg peptide

RSC Advances ◽  
2014 ◽  
Vol 4 (32) ◽  
pp. 16517-16523 ◽  
Author(s):  
Keerthana Ramaswamy ◽  
Priyadharshini Kumaraswamy ◽  
Swaminathan Sethuraman ◽  
Uma Maheswari Krishnan
Keyword(s):  
Amyloid Beta ◽  
Self Assembly ◽  
Amyloid Plaques ◽  
Amyloid Beta Peptide ◽  
Side Chains ◽  
Structural Analogue ◽  
Beta Peptide

This article aims to understand the pathogenesis behind the formation of amyloid plaques using a modified version of the KLVFF peptide. It was found that the cytotoxicity of the nanostructures formed by the RIVFF peptide may be attributed to the aminoacids with long side chains along with hydrophobic aminoacids resembling the amyloid beta peptide.

scholarly journals Atomistic investigation of an Iowa Amyloid-β trimer in aqueous solution

RSC Advances ◽  
2018 ◽  
Vol 8 (73) ◽  
pp. 41705-41712 ◽  
Author(s):  
Son Tung Ngo ◽  
Huong Thi Thu Phung ◽  
Khanh B. Vu ◽  
Van V. Vu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Aqueous Solution ◽  
Amyloid Beta ◽  
Amyloid Β ◽  
Amyloid Beta Peptide ◽  
Disease Pathogenesis ◽  
Beta Peptide ◽  
Potential Inhibitors

Amyloid beta peptide oligomers are believed to play key roles in Alzheimer's disease pathogenesis. D23N mutation significantly changes their structure and how they bind potential inhibitors.

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