scholarly journals Atomistic investigation of an Iowa Amyloid-β trimer in aqueous solution

RSC Advances ◽  
2018 ◽  
Vol 8 (73) ◽  
pp. 41705-41712 ◽  
Author(s):  
Son Tung Ngo ◽  
Huong Thi Thu Phung ◽  
Khanh B. Vu ◽  
Van V. Vu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Aqueous Solution ◽  
Amyloid Beta ◽  
Amyloid Β ◽  
Amyloid Beta Peptide ◽  
Disease Pathogenesis ◽  
Beta Peptide ◽  
Potential Inhibitors

Amyloid beta peptide oligomers are believed to play key roles in Alzheimer's disease pathogenesis. D23N mutation significantly changes their structure and how they bind potential inhibitors.

Deciphering an interplay of proteins associated with amyloid β 1-42 peptide and molecular mechanisms of Alzheimer’s disease

2014 ◽  
Vol 25 (6) ◽  
Author(s):  
Luis Fernando Hernández-Zimbrón ◽  
Selva Rivas-Arancibia
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Intracellular Transport ◽  
Molecular Mechanisms ◽  
Amyloid Β ◽  
Amyloid Beta Peptide ◽  
Cellular Functions ◽  
Beta Peptide ◽  
The Central Nervous System

AbstractExtracellular and intracellular accumulation of amyloid beta 1-42 peptide in different states of aggregation has been involved in the development and progression of Alzheimer’s disease. However, the precise mechanisms involved in amyloid beta peptide neurotoxicity have not been fully understood. There exists a wide variety of studies demonstrating the binding of amyloid beta peptide to a great variety of macromolecules and that such associations affect the cellular functions. This type of association involves proteins and receptors anchored to the plasma membrane of neurons or immune cells of the central nervous system as well as intracellular proteins that can alter intracellular transport, activate signaling pathways or affect proper mitochondrial function. In this review, we present some examples of such associations and the role played by these interactions, which are generally involved in the pathological progression of Alzheimer’s disease.

scholarly journals Probing oligomerization of amyloid beta peptide in silico

2017 ◽  
Vol 13 (1) ◽  
pp. 165-182 ◽  
Author(s):  
L. Dorosh ◽  
M. Stepanova
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
In Silico ◽  
Molecular Level ◽  
Amyloid Β ◽  
Amyloid Beta Peptide ◽  
Amyloid Β Peptide ◽  
Beta Peptide

Simulations reveal molecular-level details of aggregation of amyloid β peptide that is implicated in fatal Alzheimer's disease.

Detecting bioactive amyloid beta peptide species in Alzheimer's disease

2004 ◽  
Vol 91 (3) ◽  
pp. 648-656 ◽  
Author(s):  
Yuanbin Liu ◽  
Richard Dargusch ◽  
Cindy Banh ◽  
Carol A. Miller ◽  
David Schubert
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Amyloid Beta Peptide ◽  
Beta Peptide
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