Structural characterization of the 5′ untranslated RNA of hepatitis C virus by vibrational spectroscopy

2006 ◽  
Vol 124 (1) ◽  
pp. 73-79 ◽  
Author(s):  
Arantxa Rodríguez-Casado ◽  
Javier Bartolomé ◽  
Vicente Carreño ◽  
Marina Molina ◽  
Pedro Carmona
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Vibrational Spectroscopy ◽  
Structural Characterization

scholarly journals Structural characterization of the transmembrane proximal region of the hepatitis C virus E1 glycoprotein

2010 ◽  
Vol 1798 (3) ◽  
pp. 344-353 ◽  
Author(s):  
Roberta Spadaccini ◽  
Gerardino D'Errico ◽  
Viviana D'Alessio ◽  
Eugenio Notomista ◽  
Alessia Bianchi ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Structural Characterization ◽  
Proximal Region

scholarly journals Structural characterization of the Hepatitis C Virus NS3 protease from genotype 3a: The basis of the genotype 1b vs. 3a inhibitor potency shift

Virology ◽  
2010 ◽  
Vol 405 (2) ◽  
pp. 424-438 ◽  
Author(s):  
Mariana Gallo ◽  
Matthew James Bottomley ◽  
Matteo Pennestri ◽  
Tommaso Eliseo ◽  
Maurizio Paci ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Structural Characterization ◽  
Genotype 1B ◽  
Ns3 Protease ◽  
Genotype 3A

Structural characterization of CD81–Claudin-1 hepatitis C virus receptor complexes

2011 ◽  
Vol 39 (2) ◽  
pp. 537-540 ◽  
Author(s):  
Nicklas Bonander ◽  
Mohammed Jamshad ◽  
Ke Hu ◽  
Michelle J. Farquhar ◽  
Zania Stamataki ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Structural Characterization ◽  
Biological Function ◽  
Transmembrane Domain ◽  
Therapeutic Agents ◽  
Lateral Movement ◽  
Receptor Complexes ◽  
Major Structural Component

Tetraspanins are thought to exert their biological function(s) by co-ordinating the lateral movement and trafficking of associated molecules into tetraspanin-enriched microdomains. A second four-TM (transmembrane) domain protein family, the Claudin superfamily, is the major structural component of cellular TJs (tight junctions). Although the Claudin family displays low sequence homology and appears to be evolutionarily distinct from the tetraspanins, CD81 and Claudin-1 are critical molecules defining HCV (hepatitis C virus) entry; we recently demonstrated that CD81–Claudin-1 complexes have an essential role in this process. To understand the molecular basis of CD81–Claudin-1 complex formation, we produced and purified milligram quantities of full-length CD81 and Claudin-1, alone and in complex, in both detergent and lipid contexts. Structural characterization of these purified proteins will allow us to define the mechanism(s) underlying virus–cell interactions and aid the design of therapeutic agents targeting early steps in the viral life cycle.

NMR Structural Characterization of Peptide Inhibitors Bound to the Hepatitis C Virus NS3 Protease:  Design of a New P2 Substituent

2004 ◽  
Vol 47 (1) ◽  
pp. 123-132 ◽  
Author(s):  
Nathalie Goudreau ◽  
Dale R. Cameron ◽  
Pierre Bonneau ◽  
Vida Gorys ◽  
Céline Plouffe ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Structural Characterization ◽  
Peptide Inhibitors ◽  
Ns3 Protease

scholarly journals Characterization of a hepatitis C virus genotype 1 divergent isolate from an HIV-1 coinfected individual in Germany assigned to a new subtype 1o

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Bo Wang ◽  
Luise Krüger ◽  
Patrycja Machnowska ◽  
Amare Eshetu ◽  
Barbara Gunsenheimer-Bartmeyer ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Genotype 1 ◽  
Virus Genotype ◽  
Hiv 1
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