Antagonists to TRPV1, ASICs and P2X have a potential role to prevent the triggering of regional bone metabolic disorder and pain-like behavior in tail-suspended mice

Bone ◽  
2018 ◽  
Vol 110 ◽  
pp. 284-294 ◽  
Author(s):  
Megumi Hanaka ◽  
Kousuke Iba ◽  
Takayuki Dohke ◽  
Kumiko Kanaya ◽  
Shunichiro Okazaki ◽  
...  
Keyword(s):  
Metabolic Disorder ◽  
Potential Role ◽  
Bone Metabolic Disorder

scholarly journals Bone metabolic disorder and its contributing factors in patients with chronic kidney disease; a three-year cohort study

2021 ◽  
Vol 11 (1) ◽  
pp. e5-e5
Author(s):  
Kourosh Eftekharian ◽  
Hassan Eftekhar Ardebili ◽  
Mohammad Hossein Shojamoradi ◽  
Sahar Samimi
Keyword(s):  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Calcium Phosphate ◽  
Kidney Disease ◽  
Metabolic Disorder ◽  
Serum Phosphate ◽  
Phosphate Level ◽  
Advanced Stages ◽  
Phosphate Product ◽  
Bone Metabolic Disorder

Introduction: The prevalence of bone mineral disorder is best known in end-stage renal disease (ESRD) patients, but less data is available for the earlier stages. Objectives: We aimed to compare the prevalence of bone metabolic disorder at all stages of chronic kidney disease (CKD) and assess its contribution to CKD progression and patients’ outcome. Patients and Methods: In a retrospective cohort study, CKD patients who were under treatment for three years were selected from a nephrology clinic in Tehran, Iran. Patients’ demographic and laboratory data, as well as the outcome of their treatment were gathered and analyzed. Results: In 473 patients with an average age of 61.5, 60.1% were at stage III, 35.8% were at stage IV, and 4.1% were at stage V of CKD. There was a significant relationship between CKD stage and serum phosphate, calcium-phosphate product, and systolic blood pressure (SBP). Furthermore, the patients’ outcome was significantly related to advanced stages of CKD, higher first phosphate level, diabetes mellitus in medical history, and higher stages of SBP. By multiple Cox regression analysis, after adjustment for glomerular filtration rate (GFR), the first serum phosphate level, and the calcium-phosphate product did not contribute to the undesirable outcome. Conclusion: Although bone metabolic disorder is more frequently seen in advanced stages of chronic kidney disease, these changes can be seen even in earlier stages of the disease. The influence of phosphate abnormality in the patients’ outcome should be studied more in earlier stages for better control.

Action of green tea catechin on bone metabolic disorder in chronic cadmium-poisoned rats

Life Sciences ◽  
2003 ◽  
Vol 73 (12) ◽  
pp. 1479-1489 ◽  
Author(s):  
Jeong-Hwa Choi ◽  
In-Koo Rhee ◽  
Keun-Yong Park ◽  
Kun-Young Park ◽  
Jong-Ki Kim ◽  
...  
Keyword(s):  
Green Tea ◽  
Metabolic Disorder ◽  
Green Tea Catechin ◽  
Bone Metabolic Disorder

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

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