scholarly journals Age-related Contribution of Lp (a) with Coronary Artery Calcification in Patients with Acute Coronary Syndrome: a Potential Role of Metabolic Disorder in Calcified Plaque

2003 ◽  
Vol 44 (3) ◽  
pp. 445 ◽  
Author(s):  
Sung Kee Ryu ◽  
Bum Kee Hong ◽  
Hyuck Moon Kwon ◽  
Dong Soo Kim ◽  
Wook Jin Chung ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Metabolic Disorder ◽  
Coronary Artery Calcification ◽  
Potential Role ◽  
Coronary Syndrome ◽  
Age Related ◽  
Calcified Plaque

Abstract 4008: PSGL-1-Expressing CD4 T Cells are Enriched in Culprit Coronary Artery Lesion of Acute Coronary Syndrome

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Keiko Gomita ◽  
Kayoko Sato ◽  
Kazutaka Kitamura ◽  
Nobuhisa Hagiwara
Keyword(s):  
T Cells ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Adhesion Molecules ◽  
Peripheral Blood ◽  
Cd4 T Cells ◽  
Coronary Artery Lesion ◽  
Plaque Instability ◽  
Coronary Syndrome

Background: Recently, several evidences on the crucial role of adhesion molecules in the development of atherosclerosis and plaque instability have been reported. While expression of VCAM-1, ICAM-1 and L-selectin has been consistently observed in atherosclerotic plaques it is still uncertain how adhesion molecules on T cells contribute to the incidence of acute coronary syndrome (ACS). In this study, we examined whether adhesion molecules on T cells in ACS have a significant role in the plaque stability and prone to cause ACS. Methods and Results: Fresh CD4 T cells were isolated from the peripheral blood of 76 ACS patients (AMI=35, UAP=41) and 74 age-matched controls (NC). CD69, an activation marker of T cells, was strongly expressed on CD4 T cells from ACS than from NC by FACS (P<0.0001). CD4 T cells from ACS highly expressed p-selectin glycoprotein ligand-1 (PSGL-1) and integrin β (CD18), but not L-selectin by FACS (P < 0.03, P < 0.01, n.s., respectively). Soluble PSGL-1 (sPSGL-1) levels in plasma were lower in ACS patients than in NC (P=0.0001), which correlated negatively with the PSGL-1 expression on CD4 T cells (R=0.405, P<0.02). We further investigated the thrombus-aspirating device samples (n=14) and fresh CD4 T cells derived from both the coronary artery and peripheral blood from the each same patient with ACS. CD4 T cells from the coronary artery strongly expressed PSGL-1 (P<0.002), but not integrin β (CD18) and L-selectin by FACS. Finally, PSGL-1 was expressed on T cells, but not on CD68 positive macrophage, MPO positive neutrophil, or CD41 positive platelets in the thrombus-aspirating device samples. Conclusions: From these results, we demonstrated that PSGL-1-expressing CD4 T cells are enriched in the culprit coronary artery lesion of ACS, contributing to the acceleration of plaque instability and occurrence of ACS.

scholarly journals MicroRNAs as Regulators and Biomarkers of Platelet Function and Activity in Coronary Artery Disease

2019 ◽  
Vol 119 (10) ◽  
pp. 1563-1572 ◽  
Author(s):  
Stefan Stojkovic ◽  
Anne Yaël Nossent ◽  
Paul Haller ◽  
Bernhard Jäger ◽  
Kris G. Vargas ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Treatment Response ◽  
Platelet Function ◽  
Ribonucleic Acids ◽  
Coronary Syndrome ◽  
Artery Disease ◽  
Response Biomarkers

AbstractMicroribonucleic acids (miRs) are small, noncoding ribonucleic acids (RNAs), which play an important role in the regulation of platelet function and activity. Several studies proposed a mechanistic role of platelet-related miRs in the pathophysiology of coronary artery disease (CAD) and atherothrombosis. Circulating, platelet-related miRs have been proposed as diagnostic, prognostic, as well as treatment response biomarkers in CAD and acute coronary syndrome (ACS). In this review, we summarize recent studies on the role of platelet-related miRs in the regulation of platelet function and activity. Furthermore, we review the studies investigating the role of platelet-related miRs as biomarkers in patients with CAD and ACS.

scholarly journals The role of nutritional indexes in predicting coronary artery disease severity in acute coronary syndrome

2021 ◽  
Vol 63 (2) ◽  
pp. 147-152
Author(s):  
Hatice Tolunay ◽  
Suat Görmel ◽  
Serkan Asil ◽  
Salim Yaşar ◽  
Erkan Yıldırım ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Disease Severity ◽  
Coronary Syndrome ◽  
Coronary Artery Disease Severity ◽  
Artery Disease
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