scholarly journals Comparison of cyclic and impact-based reference point indentation measurements in human cadaveric tibia

Bone ◽  
2018 ◽  
Vol 106 ◽  
pp. 90-95 ◽  
Author(s):  
Lamya Karim ◽  
Miranda Van Vliet ◽  
Mary L. Bouxsein
Keyword(s):  
Reference Point ◽  
Reference Point Indentation

Bone material properties as measured by Reference Point Indentation are low in subjects with acromegaly

2016 ◽  
Author(s):  
Frank Malgo ◽  
Neveen A T Hamdy ◽  
Alberto M Pereira ◽  
Nienke R Biermasz ◽  
Natasha M Appelman-Dijkstra
Keyword(s):  
Material Properties ◽  
Reference Point ◽  
Bone Material ◽  
Bone Material Properties ◽  
Reference Point Indentation

scholarly journals Microhardness distribution of the tibial diaphysis and test site selection for reference point indentation technique

Medicine ◽  
2019 ◽  
Vol 98 (29) ◽  
pp. e16523 ◽  
Author(s):  
Jianzhao Wang ◽  
Bing Yin ◽  
Guobin Liu ◽  
Sheng Li ◽  
Xiaojuan Zhang ◽  
...  
Keyword(s):  
Site Selection ◽  
Reference Point ◽  
Test Site ◽  
Indentation Technique ◽  
Tibial Diaphysis ◽  
Microhardness Distribution ◽  
Reference Point Indentation ◽  
Selection For

scholarly journals Determination of Elastic Modulus in Mouse Bones Using a Nondestructive Micro-Indentation Technique Using Reference Point Indentation

2018 ◽  
Vol 140 (7) ◽  
Author(s):  
Ganesh Thiagarajan ◽  
Mark T. Begonia ◽  
Mark Dallas ◽  
Nuria Lara-Castillo ◽  
JoAnna M. Scott ◽  
...  
Keyword(s):  
Elastic Modulus ◽  
Reference Point ◽  
Ex Vivo ◽  
Numerical Procedure ◽  
Indentation Modulus ◽  
Three Point Bending ◽  
Bending Modulus ◽  
Reference Point Indentation

The determination of the elastic modulus of bone is important in studying the response of bone to loading and is determined using a destructive three-point bending method. Reference point indentation (RPI), with one cycle of indentation, offers a nondestructive alternative to determine the elastic modulus. While the elastic modulus could be determined using a nondestructive procedure for ex vivo experiments, for in vivo testing, the three-point bending technique may not be practical and hence RPI is viewed as a potential alternative and explored in this study. Using the RPI measurements, total indentation distance (TID), creep indentation distance, indentation force, and the unloading slope, we have developed a numerical analysis procedure using the Oliver–Pharr (O/P) method to estimate the indentation elastic modulus. Two methods were used to determine the area function: (1) Oliver–Pharr (O/P—based on a numerical procedure) and (2) geometric (based on the calculation of the projected area of indentation). The indentation moduli of polymethyl methacrylate (PMMA) calculated by the O/P (3.49–3.68 GPa) and geometric (3.33–3.49 GPa) methods were similar to values in literature (3.5–4 GPa). In a study using femurs from C57Bl/6 mice of different ages and genders, the three-point bending modulus was lower than the indentation modulus. In femurs from 4 to 5 months old TOPGAL mice, we found that the indentation modulus from the geometric (5.61 ± 1.25 GPa) and O/P (5.53 ± 1.27 GPa) methods was higher than the three-point bending modulus (5.28 ± 0.34 GPa). In females, the indentation modulus from the geometric (7.45 ± 0.86 GPa) and O/P (7.46 ± 0.92 GPa) methods was also higher than the three-point bending modulus (7.33 ± 1.13 GPa). We can conclude from this study that the RPI determined values are relatively close to three-point bending values.

scholarly journals Microstructural and compositional contributions towards the mechanical behavior of aging human bone measured by cyclic and impact reference point indentation

Bone ◽  
2016 ◽  
Vol 87 ◽  
pp. 37-43 ◽  
Author(s):  
Adam C. Abraham ◽  
Avinesh Agarwalla ◽  
Aditya Yadavalli ◽  
Jenny Y. Liu ◽  
Simon Y. Tang
Keyword(s):  
Mechanical Behavior ◽  
Reference Point ◽  
Human Bone ◽  
Reference Point Indentation

scholarly journals Reference point indentation is not indicative of whole mouse bone measures of stress intensity fracture toughness

Bone ◽  
2014 ◽  
Vol 69 ◽  
pp. 174-179 ◽  
Author(s):  
Alessandra Carriero ◽  
Jan L. Bruse ◽  
Karla J. Oldknow ◽  
José Luis Millán ◽  
Colin Farquharson ◽  
...  
Keyword(s):  
Fracture Toughness ◽  
Stress Intensity ◽  
Reference Point ◽  
Reference Point Indentation

scholarly journals In vivo reference point indentation measurement variability in skeletally mature inbred mice

2015 ◽  
Vol 4 ◽  
Author(s):  
Andrew Srisuwananukorn ◽  
Matthew R Allen ◽  
Drew M Brown ◽  
Joseph M Wallace ◽  
Jason M Organ
Keyword(s):  
Reference Point ◽  
Inbred Mice ◽  
Measurement Variability ◽  
Reference Point Indentation ◽  
Indentation Measurement
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