scholarly journals Effects of minodronate on cortical bone response to mechanical loading in rats

Bone ◽  
2013 ◽  
Vol 53 (1) ◽  
pp. 277-283 ◽  
Author(s):  
Keita Nagira ◽  
Hiroshi Hagino ◽  
Yasuhiro Kameyama ◽  
Ryota Teshima
Keyword(s):  
Cortical Bone ◽  
Mechanical Loading ◽  
Bone Response

scholarly journals Effects of eldecalcitol on cortical bone response to mechanical loading in rats

2015 ◽  
Vol 16 (1) ◽  
Author(s):  
Yusuke Yamasaki ◽  
Keita Nagira ◽  
Mari Osaki ◽  
Hideki Nagashima ◽  
Hiroshi Hagino
Keyword(s):  
Cortical Bone ◽  
Mechanical Loading ◽  
Bone Response

MIDKINE DEFICIENCY INCREASES THE ANABOLIC RESPONSE OF CORTICAL BONE TO MECHANICAL LOADING

2012 ◽  
Vol 45 ◽  
pp. S91
Author(s):  
Astrid Liedert ◽  
Laura Mattausch ◽  
Daniel Vogele ◽  
Marcus Pahl ◽  
Ronny Bindl ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Mechanical Loading ◽  
Anabolic Response

Mechanical loading-induced gene expression and BMD changes are different in two inbred mouse strains

2005 ◽  
Vol 99 (5) ◽  
pp. 1951-1957 ◽  
Author(s):  
Chandrasekhar Kesavan ◽  
Subburaman Mohan ◽  
Susanna Oberholtzer ◽  
Jon E. Wergedal ◽  
David J. Baylink
Keyword(s):  
Gene Expression ◽  
Mechanical Loading ◽  
Quantitative Computed Tomography ◽  
Age Groups ◽  
Marker Genes ◽  
Type I ◽  
Mineral Density ◽  
Anabolic Response ◽  
Bone Response ◽  
C3h Mice

Our goal is to evaluate skeletal anabolic response to mechanical loading in different age groups of C57B1/6J (B6) and C3H/HeJ (C3H) mice with variable loads using bone size, bone mineral density (BMD), and gene expression changes as end points. Loads of 6–9 N were applied at 2 Hz for 36 cycles for 12 days on the tibia of 10-wk-old female B6 and C3H mice. Effects of a 9-N load on 10-, 16-, and 36-wk-old C3H mice were also studied. Changes in bone parameters were measured using peripheral quantitative computed tomography, and gene expression was determined by real-time PCR. Total volumetric BMD was increased by 5 and 15%, respectively, with 8- and 9-N loads in the B6, but not the C3H, mice. Increases of 20 and 12% in periosteal circumference were reflected by dramatic 44 and 26% increases in total area in B6 and C3H mice, respectively. The bone response to bending showed no difference in the three age groups of B6 and C3H mice. At 2 days, mechanical loading resulted in significant downregulation in expression of bone resorption (BR), but not bone formation (BF) marker genes. At 4 and 8 days of loading, expression of BF marker genes (type I collagen, alkaline phosphatase, osteocalcin, and bone sialoprotein) was increased two- to threefold and expression of BR marker genes (matrix metalloproteinase-9 and thrombin receptor-activating peptide) was decreased two- to fivefold. Although expression of BF marker genes was upregulated four- to eightfold at 12 days of training, expression of BR marker genes was upregulated seven- to ninefold. Four-point bending caused significantly greater changes in expression of BF and BR marker genes in bones of the B6 than the C3H mice. We conclude that mechanical loading-induced molecular pathways are activated to a greater extent in the B6 than in the C3H mice, resulting in a higher anabolic response in the B6 mice.

Erratum to “Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1–34) on trabecular and cortical bone in mice” [Bone 43 (2008) 238–248]

Bone ◽  
2009 ◽  
Vol 45 (6) ◽  
pp. 1192-1195
Author(s):  
Toshihiro Sugiyama ◽  
Leanne K. Saxon ◽  
Gul Zaman ◽  
Alaa Moustafa ◽  
Andrew Sunters ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Cortical Bone ◽  
Mechanical Loading

scholarly journals Skeletal response to whole body vibration and dietary calcium and phosphorus in growing pigs

2019 ◽  
Vol 97 (8) ◽  
pp. 3369-3378
Author(s):  
Chelsie J Huseman ◽  
Dennis H Sigler ◽  
Thomas H Welsh ◽  
Larry J Suva ◽  
Martha M Vogelsang ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Bone Remodeling ◽  
Whole Body Vibration ◽  
Growing Pigs ◽  
Whole Body ◽  
Collagen Crosslinks ◽  
Body Vibration ◽  
Adequate Diet ◽  
Bone Response ◽  
Osteogenic Response

AbstractThe quality and strength of the skeleton is regulated by mechanical loading and adequate mineral intake of calcium (Ca) and phosphorus (P). Whole body vibration (WBV) has been shown to elicit adaptive responses in the skeleton, such as increased bone mass and strength. This experiment was designed to determine the effects of WBV and dietary Ca and P on bone microarchitecture and turnover. A total of 26 growing pigs were utilized in a 60-d experiment. Pigs were randomly assigned within group to a 2 × 2 factorial design with dietary Ca and P concentration (low and adequate) as well as WBV. The adequate diet was formulated to meet all nutritional needs according to the NRC recommendations for growing pigs. Low Ca, P diets had 0.16% lower Ca and 0.13% lower P than the adequate diet. Pigs receiving WBV were vibrated 30 min/d, 3 d/wk at a magnitude of 1 to 2 mm and a frequency of 50 Hz. On days 0, 30, and 60, digital radiographs were taken to determine bone mineral content by radiographic bone aluminum equivalency (RBAE) and serum was collected to measure biochemical markers of bone formation (osteocalcin, OC) and bone resorption (carboxy-terminal collagen crosslinks, CTX-I). At day 60, pigs were euthanized and the left third metacarpal bone was excised for detailed analysis by microcomputed tomography (microCT) to measure trabecular microarchitecture and cortical bone geometry. Maximum RBAE values for the medial or lateral cortices were not affected (P > 0.05) by WBV. Pigs fed adequate Ca and P tended (P = 0.10) to have increased RBAE max values for the medial and lateral cortices. WBV pigs had significantly decreased serum CTX-1 concentrations (P = 0.044), whereas animals fed a low Ca and P diet had increased (P < 0.05) OC concentrations. In bone, WBV pigs showed a significantly lower trabecular number (P = 0.002) and increased trabecular separation (P = 0.003), whereas cortical bone parameters were not significantly altered by WBV or diet (P > 0.05). In summary, this study confirmed the normal physiological responses of the skeleton to a low Ca, P diet. Interestingly, although the WBV protocol utilized in this study did not elicit any significant osteogenic response, decreases in CTX-1 in response to WBV may have been an early local adaptive bone response. We interpret these data to suggest that the frequency and amplitude of WBV was likely sufficient to elicit a bone remodeling response, but the duration of the study may not have captured the full extent of an entire bone remodeling cycle.

Chemical structure effects on bone response to mechanical loading

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S390
Author(s):  
Peizhi Zhu ◽  
Jiadi Xu ◽  
Michael Morris ◽  
David Kohn ◽  
Ayyalusamy Ramamoorthy
Keyword(s):  
Mechanical Loading ◽  
Chemical Structure ◽  
Bone Response

Histological evaluation of the bone response to calcium phosphate cement implanted in cortical bone

Biomaterials ◽  
2003 ◽  
Vol 24 (6) ◽  
pp. 989-1000 ◽  
Author(s):  
E.M Ooms ◽  
J.G.C Wolke ◽  
M.T van de Heuvel ◽  
B Jeschke ◽  
J.A Jansen
Keyword(s):  
Calcium Phosphate ◽  
Cortical Bone ◽  
Calcium Phosphate Cement ◽  
Histological Evaluation ◽  
Bone Response
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