Effect of a selective agonist for prostaglandin E receptor subtype EP4 (ONO-4819) on the cortical bone response to mechanical loading

Bone ◽  
2005 ◽  
Vol 36 (3) ◽  
pp. 444-453 ◽  
Author(s):  
H. Hagino ◽  
M. Kuraoka ◽  
Y. Kameyama ◽  
T. Okano ◽  
R. Teshima
Keyword(s):  
Cortical Bone ◽  
Mechanical Loading ◽  
Prostaglandin E ◽  
Receptor Subtype ◽  
Selective Agonist ◽  
Bone Response

Effect of Prostaglandin E Receptor Subtype EP4 Selective Agonist on the Secretion of Tumor Necrosis Factor-?? by Macrophages in Acute Ethanol-Loaded Rats

2004 ◽  
Vol 28 (Supplement) ◽  
pp. 123S-128S
Author(s):  
Yoshihiro Nakatani ◽  
Toshiyuki Kitazawa ◽  
Masao Fujimoto ◽  
Nobuhiro Tamura ◽  
Masahito Uemura ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Prostaglandin E ◽  
Receptor Subtype ◽  
Selective Agonist ◽  
Acute Ethanol ◽  
Necrosis Factor

scholarly journals Effects of minodronate on cortical bone response to mechanical loading in rats

Bone ◽  
2013 ◽  
Vol 53 (1) ◽  
pp. 277-283 ◽  
Author(s):  
Keita Nagira ◽  
Hiroshi Hagino ◽  
Yasuhiro Kameyama ◽  
Ryota Teshima
Keyword(s):  
Cortical Bone ◽  
Mechanical Loading ◽  
Bone Response

scholarly journals Effects of eldecalcitol on cortical bone response to mechanical loading in rats

2015 ◽  
Vol 16 (1) ◽  
Author(s):  
Yusuke Yamasaki ◽  
Keita Nagira ◽  
Mari Osaki ◽  
Hideki Nagashima ◽  
Hiroshi Hagino
Keyword(s):  
Cortical Bone ◽  
Mechanical Loading ◽  
Bone Response

scholarly journals Pharmacological characterization of a selective agonist for bombesin receptor subtype-3

2009 ◽  
Vol 387 (2) ◽  
pp. 283-288 ◽  
Author(s):  
Li Zhang ◽  
Hans-Peter Nothacker ◽  
Zhiwei Wang ◽  
Laura M. Bohn ◽  
Olivier Civelli
Keyword(s):  
Receptor Subtype ◽  
Pharmacological Characterization ◽  
Selective Agonist ◽  
Bombesin Receptor ◽  
Subtype 3

MIDKINE DEFICIENCY INCREASES THE ANABOLIC RESPONSE OF CORTICAL BONE TO MECHANICAL LOADING

2012 ◽  
Vol 45 ◽  
pp. S91
Author(s):  
Astrid Liedert ◽  
Laura Mattausch ◽  
Daniel Vogele ◽  
Marcus Pahl ◽  
Ronny Bindl ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Mechanical Loading ◽  
Anabolic Response

Mechanical loading-induced gene expression and BMD changes are different in two inbred mouse strains

2005 ◽  
Vol 99 (5) ◽  
pp. 1951-1957 ◽  
Author(s):  
Chandrasekhar Kesavan ◽  
Subburaman Mohan ◽  
Susanna Oberholtzer ◽  
Jon E. Wergedal ◽  
David J. Baylink
Keyword(s):  
Gene Expression ◽  
Mechanical Loading ◽  
Quantitative Computed Tomography ◽  
Age Groups ◽  
Marker Genes ◽  
Type I ◽  
Mineral Density ◽  
Anabolic Response ◽  
Bone Response ◽  
C3h Mice

Our goal is to evaluate skeletal anabolic response to mechanical loading in different age groups of C57B1/6J (B6) and C3H/HeJ (C3H) mice with variable loads using bone size, bone mineral density (BMD), and gene expression changes as end points. Loads of 6–9 N were applied at 2 Hz for 36 cycles for 12 days on the tibia of 10-wk-old female B6 and C3H mice. Effects of a 9-N load on 10-, 16-, and 36-wk-old C3H mice were also studied. Changes in bone parameters were measured using peripheral quantitative computed tomography, and gene expression was determined by real-time PCR. Total volumetric BMD was increased by 5 and 15%, respectively, with 8- and 9-N loads in the B6, but not the C3H, mice. Increases of 20 and 12% in periosteal circumference were reflected by dramatic 44 and 26% increases in total area in B6 and C3H mice, respectively. The bone response to bending showed no difference in the three age groups of B6 and C3H mice. At 2 days, mechanical loading resulted in significant downregulation in expression of bone resorption (BR), but not bone formation (BF) marker genes. At 4 and 8 days of loading, expression of BF marker genes (type I collagen, alkaline phosphatase, osteocalcin, and bone sialoprotein) was increased two- to threefold and expression of BR marker genes (matrix metalloproteinase-9 and thrombin receptor-activating peptide) was decreased two- to fivefold. Although expression of BF marker genes was upregulated four- to eightfold at 12 days of training, expression of BR marker genes was upregulated seven- to ninefold. Four-point bending caused significantly greater changes in expression of BF and BR marker genes in bones of the B6 than the C3H mice. We conclude that mechanical loading-induced molecular pathways are activated to a greater extent in the B6 than in the C3H mice, resulting in a higher anabolic response in the B6 mice.

Erratum to “Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1–34) on trabecular and cortical bone in mice” [Bone 43 (2008) 238–248]

Bone ◽  
2009 ◽  
Vol 45 (6) ◽  
pp. 1192-1195
Author(s):  
Toshihiro Sugiyama ◽  
Leanne K. Saxon ◽  
Gul Zaman ◽  
Alaa Moustafa ◽  
Andrew Sunters ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Cortical Bone ◽  
Mechanical Loading
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