Evaluation of high-resolution peripheral quantitative computed tomography, finite element analysis and biomechanical testing in a pre-clinical model of osteoporosis: A study with odanacatib treatment in the ovariectomized adult rhesus monkey

Bone ◽  
2012 ◽  
Vol 50 (6) ◽  
pp. 1379-1388 ◽  
Author(s):  
Richa Y. Jayakar ◽  
Antonio Cabal ◽  
John Szumiloski ◽  
Swanand Sardesai ◽  
Eual A. Phillips ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Finite Element Analysis ◽  
Finite Element ◽  
High Resolution ◽  
Rhesus Monkey ◽  
Quantitative Computed Tomography ◽  
Biomechanical Testing ◽  
Peripheral Quantitative Computed Tomography ◽  
Element Analysis ◽  
Clinical Model

scholarly journals Effects of Scan Resolutions and Element Sizes on Bovine Vertebral Mechanical Parameters from Quantitative Computed Tomography-Based Finite Element Analysis

2017 ◽  
Vol 2017 ◽  
pp. 1-14 ◽  
Author(s):  
Meng Zhang ◽  
Jiazi Gao ◽  
Xu Huang ◽  
He Gong ◽  
Min Zhang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Finite Element Analysis ◽  
Finite Element ◽  
Quantitative Computed Tomography ◽  
Slice Thickness ◽  
Mechanical Parameters ◽  
Ct Scanner ◽  
Computational Accuracy ◽  
Element Analysis ◽  
Vertebral Strength

Quantitative computed tomography-based finite element analysis (QCT/FEA) has been developed to predict vertebral strength. However, QCT/FEA models may be different with scan resolutions and element sizes. The aim of this study was to explore the effects of scan resolutions and element sizes on QCT/FEA outcomes. Nine bovine vertebral bodies were scanned using the clinical CT scanner and reconstructed from datasets with the two-slice thickness, that is, 0.6 mm (PA resolution) and 1 mm (PB resolution). There were significantly linear correlations between the predicted and measured principal strains (R2>0.7, P<0.0001), and the predicted vertebral strength and stiffness were modestly correlated with the experimental values (R2>0.6, P<0.05). Two different resolutions and six different element sizes were combined in pairs, and finite element (FE) models of bovine vertebral cancellous bones in the 12 cases were obtained. It showed that the mechanical parameters of FE models with the PB resolution were similar to those with the PA resolution. The computational accuracy of FE models with the element sizes of 0.41 × 0.41 × 0.6 mm3 and 0.41 × 0.41 × 1 mm3 was higher by comparing the apparent elastic modulus and yield strength. Therefore, scan resolution and element size should be chosen optimally to improve the accuracy of QCT/FEA.

scholarly journals COMPUTER AIDED THREE-DIMENSIONAL RECONSTRUCTION AND MODELING OF MIDDLE EAR BIOMECHANICS BY HIGH-RESOLUTION COMPUTED TOMOGRAPHY AND FINITE ELEMENT ANALYSIS

2006 ◽  
Vol 18 (05) ◽  
pp. 214-221 ◽  
Author(s):  
CHIA-FONE LEE ◽  
PEIR-RONG CHEN ◽  
WEN-JENG LEE ◽  
JYH-HORNG CHEN ◽  
TIEN-CHEN LIU
Keyword(s):  
Computed Tomography ◽  
Finite Element Analysis ◽  
Finite Element ◽  
High Resolution ◽  
Temporal Bone ◽  
Middle Ear ◽  
Histological Section ◽  
Slice Thickness ◽  
High Resolution Computed Tomography ◽  
Element Analysis

In order to present a systematic and practical approach that uses high-resolution computed tomography (HRCT) to derive models of the middle ear for finite element analysis (FEA). This prospective study included 31 subjects with normal hearing and no previous otological disorders. Temporal bone images obtained from 15 right ears and 16 left ears were used for evaluation and reconstruction. High-resolution computed tomography of temporal bone was performed using simultaneous acquisition of 16 sections with a collimated slice thickness of 0.625 mm. All images were transferred to an Amira visualization system for 3D reconstruction. The created 3-D model was translated into two commercial modeling packages, Patran and ANSYS, for finite element analysis. The characteristic dimensions of the model were measured and compared with previous published histological section data. This result confirms that the geometric model created by the proposed method is accurate except the tympanic membrane is thicker than that of histological section method. No obvious difference in the geometrical dimension between right and left ossicles was found (p > 0.05). The 3D model created by finite element method and predicted umbo and stapes displacements are close to the bounds of the experimental curves of Nishihara's, Huber's, and Gan's data across the frequency range of 100-8000 Hz. The model includes a description of the geometry of the middle ear components, and dynamic equations of vibration. The proposed method is quick, practical, low cost and most importantly, non-invasive as compared with histological section methods.

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