Relation between circulation measles virus antibodies and disease severity in Paget's disease: The prism study

Bone ◽  
2011 ◽  
Vol 48 ◽  
pp. S241
Author(s):  
M. Rios Visconti⁎ ◽  
A.L. Langston ◽  
Kirsteen Goodman ◽  
P.L. Selby ◽  
W.D. Fraser ◽  
...  
Keyword(s):  
Disease Severity ◽  
Measles Virus ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Measles Virus Antibodies

scholarly journals Failure to Detect Measles Virus Ribonucleic Acid in Bone Cells from Patients with Paget’s Disease

2008 ◽  
Vol 93 (4) ◽  
pp. 1398-1401 ◽  
Author(s):  
Brya G. Matthews ◽  
Muhammad A. Afzal ◽  
Philip D. Minor ◽  
Usha Bava ◽  
Karen E. Callon ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Measles Virus ◽  
Bone Cells ◽  
Bone Marrow Cells ◽  
Subacute Sclerosing Panencephalitis ◽  
Paget’S Disease ◽  
Pcr Amplification ◽  
Positive Control ◽  
Paget's Disease ◽  
Marrow Cells

Abstract Background: Paget’s disease is a condition of focal accelerated bone turnover. Electron-microscopy investigations of osteoclasts from pagetic lesions have identified nuclear inclusion bodies that have a similar appearance to viral nucleocapsid particles. Subsequently, RNA from several paramyxoviruses has been detected in pagetic tissue, and it was suggested that these viruses, in particular measles, might play a role in the etiology of Paget’s disease. We have tested for measles virus sequences in osteoblasts and bone marrow cells collected from pagetic lesions and healthy bone. Methods: Bone and bone marrow samples were taken from Paget’s patients and control subjects, and cells were cultured from each of these tissues. RNA was extracted from 13 osteoblast cultures and 13 cultures of bone marrow cells derived from pagetic lesions, and from 26 and 23 control osteoblast and bone marrow cultures, respectively. These samples were sourced from 22 patients with Paget’s disease and 31 controls. RT-PCR-nested PCR amplification was used for the detection of the genes for the measles nucleocapsid and matrix proteins. Results: Measles virus sequences were not detected in any of the pagetic or control samples. However, measles virus sequences were identified in samples of a measles virus culture isolate included as a positive control, and in a brain sample from a patient with subacute sclerosing panencephalitis, a condition associated with chronic measles infection. Conclusion: The results of the study do not support the hypothesis that measles virus plays a role in the pathogenesis of Paget’s disease.

scholarly journals Measles virus nucleocapsid protein increases osteoblast differentiation in Paget’s disease

2016 ◽  
Vol 126 (3) ◽  
pp. 1012-1022 ◽  
Author(s):  
Jumpei Teramachi ◽  
Yuki Nagata ◽  
Khalid Mohammad ◽  
Yuji Inagaki ◽  
Yasuhisa Ohata ◽  
...  
Keyword(s):  
Nucleocapsid Protein ◽  
Measles Virus ◽  
Osteoblast Differentiation ◽  
Paget’S Disease ◽  
Paget's Disease

Measles virus nucleocapsid transcript expression is not restricted to the osteoclast lineage in patients with Paget's disease of bone

1999 ◽  
Vol 27 (10) ◽  
pp. 1528-1532 ◽  
Author(s):  
Sakamuri V. Reddy ◽  
Cheikh Menaa ◽  
Frederick R. Singer ◽  
Tim Cundy ◽  
Jillian Cornish ◽  
...  
Keyword(s):  
Measles Virus ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Transcript Expression ◽  
Paget's Disease Of Bone

scholarly journals Contributions of the Measles Virus Nucleocapsid Gene and the SQSTM1/p62P392L Mutation to Paget's Disease

2011 ◽  
Vol 13 (1) ◽  
pp. 23-34 ◽  
Author(s):  
Noriyoshi Kurihara ◽  
Yuko Hiruma ◽  
Kei Yamana ◽  
Laëtitia Michou ◽  
Côme Rousseau ◽  
...  
Keyword(s):  
Measles Virus ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Nucleocapsid Gene
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