Plasma levels of dickkopf-1 in neuroblastoma patients: Clinical significance and prognostic value

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S108
Author(s):  
S.R. Baglìo ◽  
N. Baldini ◽  
M.V. Corrias ◽  
A. Garaventa ◽  
G. Cangemi ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Plasma Levels ◽  
Prognostic Value ◽  
Dickkopf 1

Neuroblastoma and bone metastases: Clinical significance and prognostic value of Dickkopf 1 plasma levels

Bone ◽  
2011 ◽  
Vol 48 (1) ◽  
pp. 152-159 ◽  
Author(s):  
Donatella Granchi ◽  
Maria Valeria Corrias ◽  
Alberto Garaventa ◽  
Serena Rubina Baglìo ◽  
Giuliana Cangemi ◽  
...  
Keyword(s):  
Bone Metastases ◽  
Clinical Significance ◽  
Plasma Levels ◽  
Prognostic Value ◽  
Dickkopf 1

Diagnostic and Prognostic Value of Plasma Levels of Cardiac Myosin Binding Protein-C as a Novel Biomarker in Heart Failure

2016 ◽  
Vol 38 (2) ◽  
pp. 418-424 ◽  
Author(s):  
Doaa El Amrousy ◽  
Hossam Hodeib ◽  
Ghada Suliman ◽  
Nahed Hablas ◽  
Eman Ramadan Salama ◽  
...  
Keyword(s):  
Heart Failure ◽  
Plasma Levels ◽  
Protein C ◽  
Prognostic Value ◽  
Binding Protein ◽  
Cardiac Myosin ◽  
Myosin Binding Protein ◽  
Myosin Binding Protein C ◽  
Myosin Binding ◽  
Diagnostic And Prognostic Value

The Clinical Significance and Prognostic Value of HER2 Expression in Bladder Cancer: a Systematic Review and Meta-analysis

2020 ◽  
Author(s):  
Kai Gan ◽  
Yue Gao ◽  
KuangZheng Liu ◽  
Bin Xu ◽  
Ming Chen
Keyword(s):  
Bladder Cancer ◽  
Clinical Significance ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Growth Factor Receptor ◽  
Tumor Stage ◽  
The Cancer Genome Atlas ◽  
Her2 Expression ◽  
Large Tumor ◽  
Normal Tissues

Abstract Objective: Human Epidermal Growth Factor Receptor 2 (HER2) is highly expressed in a variety of tumors and associated with patients’ prognosis, but its role in bladder cancer remains unclear. We conducted this meta-analysis to explore the clinical significance and prognostic value of HER2 in bladder cancer and its potentiality as an immunotherapy target.Methods: PubMed was searched for studies published between January 1, 2000 and January 1, 2020. The odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (95%CIs) were used to investigate the relationship between HER2 and bladder cancer. UALCAN website was used to obtain TCGA (The cancer genome atlas) database.Results: Our study includes 14 articles, 1398 patients. HER2 expression was significantly higher in bladder cancer than in normal tissues. Our meta-analysis results did not reveal any effect of gender on the expression of HER2 levels in bladder cancer patients. However, HER2 expression in male patients was significantly higher than that in women according to TCGA databases. HER2 expression was also associated with carcinoma in situ, multifocal tumors, large tumor size, high tumor stage and grade, lymph node metastases, risk of recurrence and progression, low recurrence-free survival (RFS) rate. HER2 expression status had no effect on overall survival.Conclusions: Our meta-analysis showed that HER2 expression was related to pathological malignancy and poor prognosis in bladder cancer which indicated that it could be used as an effective biomarker and therapeutic target.

scholarly journals Clinical Significance and Prognostic Value of Novel Echocardiographic Index for the Severity of Mitral Regurgitation

2020 ◽  
Vol 2 (6) ◽  
pp. 330-338
Author(s):  
Aika Daimon ◽  
Akiko Goda ◽  
Kumiko Masai ◽  
Yuko Soyama ◽  
Masanori Asakura ◽  
...  
Keyword(s):  
Mitral Regurgitation ◽  
Clinical Significance ◽  
Prognostic Value

Clinical Significance and Prognostic Value of microRNA Expression Signatures in Hepatocellular Carcinoma

2013 ◽  
Vol 19 (17) ◽  
pp. 4780-4791 ◽  
Author(s):  
Rongrong Wei ◽  
Guo-Liang Huang ◽  
Mei-Yin Zhang ◽  
Bin-Kui Li ◽  
Hui-Zhong Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Significance ◽  
Prognostic Value ◽  
Microrna Expression

Clinical significance and diagnostic value of serum dickkopf-1 in patients with hepatocellular carcinoma

2016 ◽  
Vol 51 (9) ◽  
pp. 1133-1137 ◽  
Author(s):  
Yasser M. Fouad ◽  
Hala I. Mohamed ◽  
Enas M. kamal ◽  
Mohamed A. Rasek
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Significance ◽  
Diagnostic Value ◽  
Dickkopf 1

Correlation of dickkopf-1 concentrations in plasma and synovial fluid to the severity of radiographic signs of equine osteoarthritis

2017 ◽  
Vol 30 (05) ◽  
pp. 311-317 ◽  
Author(s):  
Jillian Mills ◽  
Duncan Peters ◽  
Patty Weber ◽  
Tara Shearer ◽  
Anthony Pease ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Clinical Significance ◽  
Subchondral Bone ◽  
Bone Sclerosis ◽  
Bone Lysis ◽  
Supplementary Material ◽  
Equine Osteoarthritis ◽  
Dickkopf 1 ◽  
Mean Concentration ◽  
One Way Anova

Summary Objective: The purpose of this study was to determine whether there was a correlation between circulating and intra-synovial Dkk-1 and radiographic signs of equine osteoarthritis. Methods: Circulating and intra-synovial Dkk-1 levels were measured in clinical cases using a commercially available human Dkk-1 ELISA. Radiographs were performed of the joints from which fluid was collected and these were assessed and scored by a boarded radiologist for joint narrowing, subchondral bone sclerosis, subchondral bone lysis, and periarticular modelling. Comparisons were made between radiographic scores and the concentrations of Dkk-1 using a Kruskal-Wallis one-way ANOVA. Correlations were calculated using Kendall’s statistic. Results: A total of 42 synovial fluid samples from 21 horses were collected and used in the analysis. No significant correlation was identified between Dkk-1 concentrations and radiographic signs of osteoarthritis. Intrasynovial Dkk-1 concentrations were significantly greater (p <0.001) in low motion joints (mean concentration, 232.68 pg/mL; range, 109.07–317.17) when compared to high- motion joints (28.78 pg/mL; 0.05–186.44 pg/mL) (p <0.001). Clinical significance: Low motion joints have significantly higher concentrations of Dkk-1 compared to high motion joints. Further research is needed to establish the importance of this finding and whether potential diagnostic or therapeutic applications of Dkk-1 exist in the horse.Supplementary material for this article is available at https://doi.org/10.3415/VCOT-16-11-0157

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