scholarly journals Mining database for the clinical significance and prognostic value of CBX family in skin cutaneous melanoma

2020 ◽  
Vol 34 (12) ◽  
Author(s):  
Ding Li ◽  
YiRan Liu ◽  
Shuai Hao ◽  
Bo Chen ◽  
AnHai Li
Keyword(s):  
Clinical Significance ◽  
Cutaneous Melanoma ◽  
Prognostic Value

scholarly journals Mining database for the clinical significance and prognostic value of ESRP1 in skin cutaneous melanoma

2020 ◽  
Author(s):  
Baihe Wang ◽  
Caixia Kou ◽  
Jianfang Sun ◽  
Xiulian Xu
Keyword(s):  
Transcription Factors ◽  
Clinical Significance ◽  
Cutaneous Melanoma ◽  
Prognostic Value ◽  
Regulatory Networks ◽  
Immune Cell ◽  
Tumor Stage ◽  
Condensed Chromosome ◽  
Translational Initiation ◽  
Immune Infiltration

Abstract Background ESRP1 has been described as epithelium-specific splicing regulator involved in many tumors progression. However, the role of ESRP1 in skin cutaneous melanoma is unclear. In the present study, we explored the expression levels of ESRP1 in melanoma and its effect on prognosis and immune infiltration. Methods This study integrated the information from ONCOMINE, GEPIA and UALCAN databases. We explored the genes closely related to ESRP1 using LINKEDIMECS and further analyzed the target kinase, miRNA and transcription factors of ESRP1.GSEA software was used to analyze the changes of GO function enrichment and KEGG pathway after ESRP1 and its related 100 genes changes. Finally, TIMER was used to analyze the relationship between ESRP1 and tumor immune cell infiltration. Results The expression of ESRP1mRNA was significantly downregulated in SKCM patients in comparison with healthy control based on tumor stage and lymph node metastasis status. Low level of ESRP1 expression correlated with better overall survival. ESRP1 is specifically related to tumor-associated kinases CDK1, miRNA138, and transcription factors ETF. Functional network analysis demonstrated that ESRP1 is involved in the regulation of the condensed chromosome, epidermis development, translational initiation, ribosome, drug metabolism, and chemical carcinogenesis. Mechanistically, results suggested that ESRP1 might play an important role in regulating tumor-associated macrophages polarization, DCs infiltration, Treg cells and T cell exhaustion. Conclusion Our study demonstrates ESRP1 expression and its prognostic value and potential regulatory networks in SKCM, shedding light on the clinical significance of ESRP1 and providing a novel biomarker for determining prognosis and immune infiltration in SKCM.

Prognostic value of serum selenium level in cutaneous melanoma

1993 ◽  
Vol 3 (1) ◽  
pp. 47
Author(s):  
B. Dréno ◽  
C. Deffuant ◽  
P. Célérier ◽  
H. L. Boiteau ◽  
P. Litoux
Keyword(s):  
Cutaneous Melanoma ◽  
Prognostic Value ◽  
Selenium Level ◽  
Serum Selenium ◽  
Serum Selenium Level

The Clinical Significance and Prognostic Value of HER2 Expression in Bladder Cancer: a Systematic Review and Meta-analysis

2020 ◽  
Author(s):  
Kai Gan ◽  
Yue Gao ◽  
KuangZheng Liu ◽  
Bin Xu ◽  
Ming Chen
Keyword(s):  
Bladder Cancer ◽  
Clinical Significance ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Growth Factor Receptor ◽  
Tumor Stage ◽  
The Cancer Genome Atlas ◽  
Her2 Expression ◽  
Large Tumor ◽  
Normal Tissues

Abstract Objective: Human Epidermal Growth Factor Receptor 2 (HER2) is highly expressed in a variety of tumors and associated with patients’ prognosis, but its role in bladder cancer remains unclear. We conducted this meta-analysis to explore the clinical significance and prognostic value of HER2 in bladder cancer and its potentiality as an immunotherapy target.Methods: PubMed was searched for studies published between January 1, 2000 and January 1, 2020. The odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (95%CIs) were used to investigate the relationship between HER2 and bladder cancer. UALCAN website was used to obtain TCGA (The cancer genome atlas) database.Results: Our study includes 14 articles, 1398 patients. HER2 expression was significantly higher in bladder cancer than in normal tissues. Our meta-analysis results did not reveal any effect of gender on the expression of HER2 levels in bladder cancer patients. However, HER2 expression in male patients was significantly higher than that in women according to TCGA databases. HER2 expression was also associated with carcinoma in situ, multifocal tumors, large tumor size, high tumor stage and grade, lymph node metastases, risk of recurrence and progression, low recurrence-free survival (RFS) rate. HER2 expression status had no effect on overall survival.Conclusions: Our meta-analysis showed that HER2 expression was related to pathological malignancy and poor prognosis in bladder cancer which indicated that it could be used as an effective biomarker and therapeutic target.

scholarly journals Prognostic value of B cells in cutaneous melanoma

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Sara R. Selitsky ◽  
Lisle E. Mose ◽  
Christof C. Smith ◽  
Shengjie Chai ◽  
Katherine A. Hoadley ◽  
...  
Keyword(s):  
B Cells ◽  
Cutaneous Melanoma ◽  
Prognostic Value

scholarly journals Clinical Significance and Prognostic Value of Novel Echocardiographic Index for the Severity of Mitral Regurgitation

2020 ◽  
Vol 2 (6) ◽  
pp. 330-338
Author(s):  
Aika Daimon ◽  
Akiko Goda ◽  
Kumiko Masai ◽  
Yuko Soyama ◽  
Masanori Asakura ◽  
...  
Keyword(s):  
Mitral Regurgitation ◽  
Clinical Significance ◽  
Prognostic Value

Clinical Significance and Prognostic Value of microRNA Expression Signatures in Hepatocellular Carcinoma

2013 ◽  
Vol 19 (17) ◽  
pp. 4780-4791 ◽  
Author(s):  
Rongrong Wei ◽  
Guo-Liang Huang ◽  
Mei-Yin Zhang ◽  
Bin-Kui Li ◽  
Hui-Zhong Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Significance ◽  
Prognostic Value ◽  
Microrna Expression
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